|
|
eF-site ID
|
3t3m-C |
|
PDB Code
|
3t3m |
|
Chain
|
C |
|
click to enlarge
|
|
|
Title
|
A Novel High Affinity Integrin alphaIIbbeta3 Receptor Antagonist That Unexpectedly Displaces Mg2+ from the beta3 MIDAS |
|
Classification
|
CELL ADHESION |
|
Compound
|
Integrin alpha-IIb |
|
Source
|
(3T3M) |
|
|
Sequence
|
C: |
LNLDPVQLTFYAGPNGSQFGFSLDFHKDSHGRVAIVVGAP
RTLGPSQEETGGVFLCPWRAEGGQCPSLLFDLRDETRNVG
SQTLQTFKARQGLGASVVSWSDVIVACAPWQHWNVLEKTE
EAEKTPVGSCFLAQPESGRRAEYSPCRGNTLSRIYVENDF
SWDKRYCEAGFSSVVTQAGELVLGAPGGYYFLGLLAQAPV
ADIFSSYRPGILLWHVSSQSLSFDSSNPEYFDGYWGYSVA
VGEFDGDLNTTEYVVGAPTWSWTLGAVEILDSYYQRLHRL
RGEQMASYFGHSVAVTDVNGDGRHDLLVGAPLYMESRADR
KLAEVGRVYLFLQPRGPHALGAPSLLLTGTQLYGRFGSAI
APLGDLDRDGYNDIAVAAPYGGPSGRGQVLVFLGQSEGLR
SRPSQVLDSPFPTGSAFGFSLRGAVDIDDNGYPDLIVGAY
GANQVAVYRAQPV
|
|
|
Description
|
|
Functional site
|
|
|
1)
|
chain |
C |
| residue |
432 |
| type |
BINDING |
| sequence |
Y
|
| description |
in MIDAS binding site => ECO:0000269|PubMed:15378069, ECO:0000269|PubMed:19111664, ECO:0007744|PDB:1TYE, ECO:0007744|PDB:3FCS, ECO:0007744|PDB:3FCU
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
2)
|
chain |
C |
| residue |
434 |
| type |
BINDING |
| sequence |
D
|
| description |
in MIDAS binding site => ECO:0000269|PubMed:15378069, ECO:0000269|PubMed:19111664, ECO:0007744|PDB:1TYE, ECO:0007744|PDB:3FCS, ECO:0007744|PDB:3FCU
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
3)
|
chain |
C |
| residue |
243 |
| type |
BINDING |
| sequence |
E
|
| description |
in MIDAS binding site => ECO:0000269|PubMed:15378069, ECO:0000269|PubMed:19111664, ECO:0007744|PDB:1TYE, ECO:0007744|PDB:3FCS, ECO:0007744|PDB:3FCU
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
4)
|
chain |
C |
| residue |
245 |
| type |
BINDING |
| sequence |
D
|
| description |
in MIDAS binding site => ECO:0000269|PubMed:15378069, ECO:0000269|PubMed:19111664, ECO:0007744|PDB:1TYE, ECO:0007744|PDB:3FCS, ECO:0007744|PDB:3FCU
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
5)
|
chain |
C |
| residue |
247 |
| type |
BINDING |
| sequence |
D
|
| description |
in MIDAS binding site => ECO:0000269|PubMed:15378069, ECO:0000269|PubMed:19111664, ECO:0007744|PDB:1TYE, ECO:0007744|PDB:3FCS, ECO:0007744|PDB:3FCU
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
6)
|
chain |
C |
| residue |
250 |
| type |
BINDING |
| sequence |
T
|
| description |
in MIDAS binding site => ECO:0000269|PubMed:15378069, ECO:0000269|PubMed:19111664, ECO:0007744|PDB:1TYE, ECO:0007744|PDB:3FCS, ECO:0007744|PDB:3FCU
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
7)
|
chain |
C |
| residue |
252 |
| type |
BINDING |
| sequence |
E
|
| description |
in MIDAS binding site => ECO:0000269|PubMed:15378069, ECO:0000269|PubMed:19111664, ECO:0007744|PDB:1TYE, ECO:0007744|PDB:3FCS, ECO:0007744|PDB:3FCU
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
8)
|
chain |
C |
| residue |
297 |
| type |
BINDING |
| sequence |
D
|
| description |
in MIDAS binding site => ECO:0000269|PubMed:15378069, ECO:0000269|PubMed:19111664, ECO:0007744|PDB:1TYE, ECO:0007744|PDB:3FCS, ECO:0007744|PDB:3FCU
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
9)
|
chain |
C |
| residue |
299 |
| type |
BINDING |
| sequence |
N
|
| description |
in MIDAS binding site => ECO:0000269|PubMed:15378069, ECO:0000269|PubMed:19111664, ECO:0007744|PDB:1TYE, ECO:0007744|PDB:3FCS, ECO:0007744|PDB:3FCU
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
10)
|
chain |
C |
| residue |
301 |
| type |
BINDING |
| sequence |
D
|
| description |
in MIDAS binding site => ECO:0000269|PubMed:15378069, ECO:0000269|PubMed:19111664, ECO:0007744|PDB:1TYE, ECO:0007744|PDB:3FCS, ECO:0007744|PDB:3FCU
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
11)
|
chain |
C |
| residue |
303 |
| type |
BINDING |
| sequence |
R
|
| description |
in MIDAS binding site => ECO:0000269|PubMed:15378069, ECO:0000269|PubMed:19111664, ECO:0007744|PDB:1TYE, ECO:0007744|PDB:3FCS, ECO:0007744|PDB:3FCU
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
12)
|
chain |
C |
| residue |
305 |
| type |
BINDING |
| sequence |
D
|
| description |
in MIDAS binding site => ECO:0000269|PubMed:15378069, ECO:0000269|PubMed:19111664, ECO:0007744|PDB:1TYE, ECO:0007744|PDB:3FCS, ECO:0007744|PDB:3FCU
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
13)
|
chain |
C |
| residue |
365 |
| type |
BINDING |
| sequence |
D
|
| description |
in MIDAS binding site => ECO:0000269|PubMed:15378069, ECO:0000269|PubMed:19111664, ECO:0007744|PDB:1TYE, ECO:0007744|PDB:3FCS, ECO:0007744|PDB:3FCU
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
14)
|
chain |
C |
| residue |
367 |
| type |
BINDING |
| sequence |
D
|
| description |
in MIDAS binding site => ECO:0000269|PubMed:15378069, ECO:0000269|PubMed:19111664, ECO:0007744|PDB:1TYE, ECO:0007744|PDB:3FCS, ECO:0007744|PDB:3FCU
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
15)
|
chain |
C |
| residue |
369 |
| type |
BINDING |
| sequence |
D
|
| description |
in MIDAS binding site => ECO:0000269|PubMed:15378069, ECO:0000269|PubMed:19111664, ECO:0007744|PDB:1TYE, ECO:0007744|PDB:3FCS, ECO:0007744|PDB:3FCU
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
16)
|
chain |
C |
| residue |
371 |
| type |
BINDING |
| sequence |
Y
|
| description |
in MIDAS binding site => ECO:0000269|PubMed:15378069, ECO:0000269|PubMed:19111664, ECO:0007744|PDB:1TYE, ECO:0007744|PDB:3FCS, ECO:0007744|PDB:3FCU
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
17)
|
chain |
C |
| residue |
373 |
| type |
BINDING |
| sequence |
D
|
| description |
in MIDAS binding site => ECO:0000269|PubMed:15378069, ECO:0000269|PubMed:19111664, ECO:0007744|PDB:1TYE, ECO:0007744|PDB:3FCS, ECO:0007744|PDB:3FCU
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
18)
|
chain |
C |
| residue |
426 |
| type |
BINDING |
| sequence |
D
|
| description |
in MIDAS binding site => ECO:0000269|PubMed:15378069, ECO:0000269|PubMed:19111664, ECO:0007744|PDB:1TYE, ECO:0007744|PDB:3FCS, ECO:0007744|PDB:3FCU
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
19)
|
chain |
C |
| residue |
428 |
| type |
BINDING |
| sequence |
D
|
| description |
in MIDAS binding site => ECO:0000269|PubMed:15378069, ECO:0000269|PubMed:19111664, ECO:0007744|PDB:1TYE, ECO:0007744|PDB:3FCS, ECO:0007744|PDB:3FCU
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
20)
|
chain |
C |
| residue |
430 |
| type |
BINDING |
| sequence |
N
|
| description |
in MIDAS binding site => ECO:0000269|PubMed:15378069, ECO:0000269|PubMed:19111664, ECO:0007744|PDB:1TYE, ECO:0007744|PDB:3FCS, ECO:0007744|PDB:3FCU
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
|