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eF-site ID
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3t3m-D |
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PDB Code
|
3t3m |
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Chain
|
D |
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Title
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A Novel High Affinity Integrin alphaIIbbeta3 Receptor Antagonist That Unexpectedly Displaces Mg2+ from the beta3 MIDAS |
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Classification
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CELL ADHESION |
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Compound
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Integrin alpha-IIb |
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Source
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(3T3M) |
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Sequence
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D: |
GPNICTTRGVSSCQQCLAVSPMCAWCSDEALPLGSPRCDL
KENLLKDNCAPESIEFPVSEARVLEDRPLSDKGSGDSSQV
TQVSPQRIALRLRPDDSKNFSIQVRQVEDYPVDIYYLMDL
SYSMKDDLWSIQNLGTKLATQMRKLTSNLRIGFGAFVDKP
VSPYMYISPPEALENPCYDMKTTCLPMFGYKHVLTLTDQV
TRFNEEVKKQSVSRNRDAPEGGFDAIMQATVCDEKIGWRN
DASHLLVFTTDAKTHIALDGRLAGIVQPNDGQCHVGSDNH
YSASTTMDYPSLGLMTEKLSQKNINLIFAVTENVVNLYQN
YSELIPGTTVGVLSMDSSNVLQLIVDAYGKIRSKVELEVR
DLPEELSLSFNATCLNNEVIPGLKSCMGLKIGDTVSFSIE
AKVRGCPQEKEKSFTIKPVGFKDSLIVQVTFDCDCACQAQ
AEPNSHRCNNGNGTFECGVCRCGPGWLGSQC
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Description
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Functional site
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|
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1)
|
chain |
D |
| residue |
158 |
| type |
BINDING |
| sequence |
D
|
| description |
in LIMBS binding site => ECO:0000269|PubMed:15378069, ECO:0000269|PubMed:19111664, ECO:0007744|PDB:1TYE, ECO:0007744|PDB:3FCS, ECO:0007744|PDB:3FCU
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| source |
Swiss-Prot : SWS_FT_FI4
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|
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2)
|
chain |
D |
| residue |
215 |
| type |
BINDING |
| sequence |
N
|
| description |
in LIMBS binding site => ECO:0000269|PubMed:15378069, ECO:0000269|PubMed:19111664, ECO:0007744|PDB:1TYE, ECO:0007744|PDB:3FCS, ECO:0007744|PDB:3FCU
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|
|
3)
|
chain |
D |
| residue |
217 |
| type |
BINDING |
| sequence |
D
|
| description |
in LIMBS binding site => ECO:0000269|PubMed:15378069, ECO:0000269|PubMed:19111664, ECO:0007744|PDB:1TYE, ECO:0007744|PDB:3FCS, ECO:0007744|PDB:3FCU
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|
|
4)
|
chain |
D |
| residue |
219 |
| type |
BINDING |
| sequence |
P
|
| description |
in LIMBS binding site => ECO:0000269|PubMed:15378069, ECO:0000269|PubMed:19111664, ECO:0007744|PDB:1TYE, ECO:0007744|PDB:3FCS, ECO:0007744|PDB:3FCU
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|
|
5)
|
chain |
D |
| residue |
251 |
| type |
BINDING |
| sequence |
D
|
| description |
in LIMBS binding site => ECO:0007744|PDB:4G1M
|
| source |
Swiss-Prot : SWS_FT_FI5
|
|
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6)
|
chain |
D |
| residue |
335 |
| type |
BINDING |
| sequence |
M
|
| description |
in ADMIDAS binding site and unliganded-closed conformation => ECO:0000269|PubMed:11546839, ECO:0000269|PubMed:19111664, ECO:0000269|PubMed:19704023, ECO:0007744|PDB:1JV2, ECO:0007744|PDB:3FCS, ECO:0007744|PDB:3IJE
|
| source |
Swiss-Prot : SWS_FT_FI6
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|
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7)
|
chain |
D |
| residue |
99 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:15378069, ECO:0000269|PubMed:16263699, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19111664, ECO:0000269|PubMed:19704023, ECO:0007744|PDB:1TYE, ECO:0007744|PDB:3IJE
|
| source |
Swiss-Prot : SWS_FT_FI7
|
|
|
8)
|
chain |
D |
| residue |
320 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:11546839, ECO:0000269|PubMed:15378069, ECO:0000269|PubMed:19111664, ECO:0000269|PubMed:19704023, ECO:0007744|PDB:1JV2, ECO:0007744|PDB:1TYE, ECO:0007744|PDB:3IJE
|
| source |
Swiss-Prot : SWS_FT_FI8
|
|
|
9)
|
chain |
D |
| residue |
371 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:11546839, ECO:0000269|PubMed:15378069, ECO:0000269|PubMed:19111664, ECO:0000269|PubMed:19704023, ECO:0007744|PDB:1JV2, ECO:0007744|PDB:1TYE, ECO:0007744|PDB:3IJE
|
| source |
Swiss-Prot : SWS_FT_FI8
|
|
|
10)
|
chain |
D |
| residue |
452 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19111664, ECO:0000269|PubMed:19704023, ECO:0007744|PDB:3IJE
|
| source |
Swiss-Prot : SWS_FT_FI9
|
|
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11)
|
chain |
D |
| residue |
121 |
| type |
BINDING |
| sequence |
S
|
| description |
in MIDAS binding site => ECO:0000269|PubMed:15378069, ECO:0000269|PubMed:19111664, ECO:0007744|PDB:1TYE, ECO:0007744|PDB:3FCS, ECO:0007744|PDB:3FCU
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
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12)
|
chain |
D |
| residue |
220 |
| type |
BINDING |
| sequence |
E
|
| description |
in MIDAS binding site => ECO:0000269|PubMed:15378069, ECO:0000269|PubMed:19111664, ECO:0007744|PDB:1TYE, ECO:0007744|PDB:3FCS, ECO:0007744|PDB:3FCU
|
| source |
Swiss-Prot : SWS_FT_FI1
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|
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13)
|
chain |
D |
| residue |
123 |
| type |
BINDING |
| sequence |
S
|
| description |
in MIDAS binding site => ECO:0000269|PubMed:15378069, ECO:0000269|PubMed:19111664, ECO:0007744|PDB:1TYE, ECO:0007744|PDB:3FCU
|
| source |
Swiss-Prot : SWS_FT_FI2
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|
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14)
|
chain |
D |
| residue |
126 |
| type |
BINDING |
| sequence |
D
|
| description |
in ADMIDAS binding site => ECO:0000269|PubMed:11546839, ECO:0000269|PubMed:15378069, ECO:0000269|PubMed:19111664, ECO:0000269|PubMed:19704023, ECO:0007744|PDB:1JV2, ECO:0007744|PDB:1TYE, ECO:0007744|PDB:3FCS, ECO:0007744|PDB:3FCU, ECO:0007744|PDB:3IJE
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
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15)
|
chain |
D |
| residue |
127 |
| type |
BINDING |
| sequence |
D
|
| description |
in ADMIDAS binding site => ECO:0000269|PubMed:11546839, ECO:0000269|PubMed:15378069, ECO:0000269|PubMed:19111664, ECO:0000269|PubMed:19704023, ECO:0007744|PDB:1JV2, ECO:0007744|PDB:1TYE, ECO:0007744|PDB:3FCS, ECO:0007744|PDB:3FCU, ECO:0007744|PDB:3IJE
|
| source |
Swiss-Prot : SWS_FT_FI3
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