eF-site ID 3t03-ABCD PDB Code 3t03 Chain A, B, C, D click to enlarge Title Crystal structure of PPAR gamma ligand binding domain in complex with a novel partial agonist GQ-16 Classification TRANSCRIPTION/TRANSCRIPTION REGULATOR Compound Peroxisome proliferator-activated receptor gamma Source ORGANISM_COMMON: human; ORGANISM_SCIENTIFIC: Homo sapiens; Sequence A:  DLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVI YDMNSLMMGEDKIKFKHIQEQSKEVAIRIFQGCQFRSVEA VQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLAS LMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAV KFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDN LLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQL LQVIKKTETDMSLHPLLQEIYKDLY B:  DLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVI YDMNSLMMGEKEVAIRIFQGCQFRSVEAVQEITEYAKSIP GFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEG QGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDL AIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLN HPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTELHPL LQEIYKDLY C:  HKILHRLL D:  HKILHRLLQEGSP Description Functional site 1) chain A residue 309 type sequence I description BINDING SITE FOR RESIDUE 3T0 A 2 source : AC1 2) chain A residue 313 type sequence C description BINDING SITE FOR RESIDUE 3T0 A 2 source : AC1 3) chain A residue 316 type sequence R description BINDING SITE FOR RESIDUE 3T0 A 2 source : AC1 4) chain A residue 317 type sequence S description BINDING SITE FOR RESIDUE 3T0 A 2 source : AC1 5) chain A residue 320 type sequence A description BINDING SITE FOR RESIDUE 3T0 A 2 source : AC1 6) chain A residue 354 type sequence I description BINDING SITE FOR RESIDUE 3T0 A 2 source : AC1 7) chain A residue 355 type sequence Y description BINDING SITE FOR RESIDUE 3T0 A 2 source : AC1 8) chain A residue 361 type sequence L description BINDING SITE FOR RESIDUE 3T0 A 2 source : AC1 9) chain A residue 369 type sequence I description BINDING SITE FOR RESIDUE 3T0 A 2 source : AC1 10) chain A residue 376 type sequence M description BINDING SITE FOR RESIDUE 3T0 A 2 source : AC1 11) chain A residue 381 type sequence L description BINDING SITE FOR RESIDUE 3T0 A 2 source : AC1 12) chain A residue 391 type sequence F description BINDING SITE FOR RESIDUE 3T0 A 2 source : AC1 13) chain A residue 392 type sequence M description BINDING SITE FOR RESIDUE 3T0 A 2 source : AC1 14) chain B residue 309 type sequence I description BINDING SITE FOR RESIDUE 3T0 B 1 source : AC2 15) chain B residue 313 type sequence C description BINDING SITE FOR RESIDUE 3T0 B 1 source : AC2 16) chain B residue 316 type sequence R description BINDING SITE FOR RESIDUE 3T0 B 1 source : AC2 17) chain B residue 317 type sequence S description BINDING SITE FOR RESIDUE 3T0 B 1 source : AC2 18) chain B residue 320 type sequence A description BINDING SITE FOR RESIDUE 3T0 B 1 source : AC2 19) chain B residue 354 type sequence I description BINDING SITE FOR RESIDUE 3T0 B 1 source : AC2 20) chain B residue 358 type sequence L description BINDING SITE FOR RESIDUE 3T0 B 1 source : AC2 21) chain B residue 361 type sequence L description BINDING SITE FOR RESIDUE 3T0 B 1 source : AC2 22) chain B residue 369 type sequence I description BINDING SITE FOR RESIDUE 3T0 B 1 source : AC2 23) chain B residue 376 type sequence M description BINDING SITE FOR RESIDUE 3T0 B 1 source : AC2 24) chain B residue 381 type sequence L description BINDING SITE FOR RESIDUE 3T0 B 1 source : AC2 25) chain B residue 391 type sequence F description BINDING SITE FOR RESIDUE 3T0 B 1 source : AC2 26) chain B residue 392 type sequence M description BINDING SITE FOR RESIDUE 3T0 B 1 source : AC2 27) chain B residue 395 type sequence K description BINDING SITE FOR RESIDUE 3T0 B 1 source : AC2 28) chain D residue 698 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI1 29) chain A residue 477 type MOD_RES sequence H description Phosphoserine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI1 30) chain A residue 501 type MOD_RES sequence Y description Phosphoserine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI1 31) chain B residue 314 type MOD_RES sequence Q description Phosphoserine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI1 32) chain B residue 351 type MOD_RES sequence H description Phosphoserine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI1 33) chain B residue 477 type MOD_RES sequence H description Phosphoserine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI1 34) chain B residue 501 type MOD_RES sequence Y description Phosphoserine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI1 35) chain A residue 252 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:36737649 source Swiss-Prot : SWS_FT_FI2 36) chain B residue 252 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:36737649 source Swiss-Prot : SWS_FT_FI2

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