eF-site ID 3sxo-AB
PDB Code 3sxo
Chain A, B

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Title Mycobacterium tuberculosis Eis protein initiates modulation of host immune responses by acetylation of DUSP16/MKP-7
Classification TRANSFERASE
Compound Enhanced intracellular survival protein
Source Mycobacterium tuberculosis (EIS_MYCTU)
Sequence A:  TVTLCSPTEDDWPGMFLLAAASFTDFIGPESATAWRTLVP
TDGAVVVRDGAGPGSEVVGMALYMDLRLTVPGEVVLPTAG
LSFVAVAPTHRRRGLLRAMCAELHRRIADSGYPVAALHAS
EGGIYGRFGYGPATTLHELTVDRRFARFHADAPGSSVRLV
RPTEHRGEFEAIYERWRQQVPGGLLRPQVLWDELLAECKA
APGGDRESFALLHPDGYALYRVDRTDLKLARVSELRAVTA
DAHCALWRALIGLDSMERISIITHPQDPLPHLLTDTRLAR
TTWRQDGLWLRIMNVPAALEARGYAHEVGEFSTVLEVSDG
GRFALKIGDGRARCTPTDAAAEIEMDRDVLGSLYLGAHRA
STLAAANRLRTKDSQLLRRLDAAFASDVPVQTAFEF
B:  TVTLCSPTEDDWPGMFLLAAASFTDFIGPESATAWRTLVP
TDGAVVVRDGAGPGSEVVGMALYMDLRLTVPGEVVLPTAG
LSFVAVAPTHRRRGLLRAMCAELHRRIADSGYPVAALHAS
EGGIYGRFGYGPATTLHELTVDRRFARFHADAPGSSVRLV
RPTEHRGEFEAIYERWRQQVPGGLLRPQVLWDELLAECKA
APGGDRESFALLHPDGYALYRVDRTDLKLARVSELRAVTA
DAHCALWRALIGLDSMERISIITHPQDPLPHLLTDTRLAR
TTWRQDGLWLRIMNVPAALEARGYAHEVGEFSTVLEVSDG
GRFALKIGDGRARCTPTDAAAEIEMDRDVLGSLYLGAHRA
STLAAANRLRTKDSQLLRRLDAAFASDVPVQTAFEF
Description


Functional site

1) chain A
residue 126
type ACT_SITE
sequence A
description Proton donor => ECO:0000305|PubMed:21628583
source Swiss-Prot : SWS_FT_FI1

2) chain B
residue 126
type ACT_SITE
sequence A
description Proton donor => ECO:0000305|PubMed:21628583
source Swiss-Prot : SWS_FT_FI1

3) chain A
residue 402
type ACT_SITE
sequence V
description Proton acceptor; via carboxylate => ECO:0000305|PubMed:21628583
source Swiss-Prot : SWS_FT_FI2

4) chain B
residue 402
type ACT_SITE
sequence V
description Proton acceptor; via carboxylate => ECO:0000305|PubMed:21628583
source Swiss-Prot : SWS_FT_FI2

5) chain A
residue 85
type BINDING
sequence T
description BINDING => ECO:0000269|PubMed:22547814, ECO:0000305|PubMed:21628583, ECO:0007744|PDB:3RYO
source Swiss-Prot : SWS_FT_FI3

6) chain A
residue 121
type BINDING
sequence V
description BINDING => ECO:0000269|PubMed:22547814, ECO:0000305|PubMed:21628583, ECO:0007744|PDB:3RYO
source Swiss-Prot : SWS_FT_FI3

7) chain B
residue 85
type BINDING
sequence T
description BINDING => ECO:0000269|PubMed:22547814, ECO:0000305|PubMed:21628583, ECO:0007744|PDB:3RYO
source Swiss-Prot : SWS_FT_FI3

8) chain B
residue 121
type BINDING
sequence V
description BINDING => ECO:0000269|PubMed:22547814, ECO:0000305|PubMed:21628583, ECO:0007744|PDB:3RYO
source Swiss-Prot : SWS_FT_FI3

9) chain A
residue 93
type BINDING
sequence V
description BINDING => ECO:0000269|PubMed:22547814, ECO:0000305|PubMed:21628583, ECO:0000305|PubMed:24106131, ECO:0000305|PubMed:27010218, ECO:0007744|PDB:3RYO
source Swiss-Prot : SWS_FT_FI4

10) chain B
residue 93
type BINDING
sequence V
description BINDING => ECO:0000269|PubMed:22547814, ECO:0000305|PubMed:21628583, ECO:0000305|PubMed:24106131, ECO:0000305|PubMed:27010218, ECO:0007744|PDB:3RYO
source Swiss-Prot : SWS_FT_FI4


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