|
|
eF-site ID
|
3sxo-A |
|
PDB Code
|
3sxo |
|
Chain
|
A |
|
click to enlarge
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Title
|
Mycobacterium tuberculosis Eis protein initiates modulation of host immune responses by acetylation of DUSP16/MKP-7 |
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Classification
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TRANSFERASE |
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Compound
|
Enhanced intracellular survival protein |
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Source
|
null (EIS_MYCTU) |
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Sequence
|
A: |
TVTLCSPTEDDWPGMFLLAAASFTDFIGPESATAWRTLVP
TDGAVVVRDGAGPGSEVVGMALYMDLRLTVPGEVVLPTAG
LSFVAVAPTHRRRGLLRAMCAELHRRIADSGYPVAALHAS
EGGIYGRFGYGPATTLHELTVDRRFARFHADAPGSSVRLV
RPTEHRGEFEAIYERWRQQVPGGLLRPQVLWDELLAECKA
APGGDRESFALLHPDGYALYRVDRTDLKLARVSELRAVTA
DAHCALWRALIGLDSMERISIITHPQDPLPHLLTDTRLAR
TTWRQDGLWLRIMNVPAALEARGYAHEVGEFSTVLEVSDG
GRFALKIGDGRARCTPTDAAAEIEMDRDVLGSLYLGAHRA
STLAAANRLRTKDSQLLRRLDAAFASDVPVQTAFEF
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Description
|
|
Functional site
|
|
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1)
|
chain |
A |
| residue |
85 |
| type |
BINDING |
| sequence |
T
|
| description |
BINDING => ECO:0000269|PubMed:22547814, ECO:0000305|PubMed:21628583, ECO:0007744|PDB:3RYO
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
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2)
|
chain |
A |
| residue |
121 |
| type |
BINDING |
| sequence |
V
|
| description |
BINDING => ECO:0000269|PubMed:22547814, ECO:0000305|PubMed:21628583, ECO:0007744|PDB:3RYO
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
3)
|
chain |
A |
| residue |
93 |
| type |
BINDING |
| sequence |
V
|
| description |
BINDING => ECO:0000269|PubMed:22547814, ECO:0000305|PubMed:21628583, ECO:0000305|PubMed:24106131, ECO:0000305|PubMed:27010218, ECO:0007744|PDB:3RYO
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|
|
4)
|
chain |
A |
| residue |
126 |
| type |
ACT_SITE |
| sequence |
A
|
| description |
Proton donor => ECO:0000305|PubMed:21628583
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
5)
|
chain |
A |
| residue |
402 |
| type |
ACT_SITE |
| sequence |
V
|
| description |
Proton acceptor; via carboxylate => ECO:0000305|PubMed:21628583
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
|