eF-site ID 3sxn-ABCDEF PDB Code 3sxn Chain A, B, C, D, E, F click to enlarge Title Mycobacterium tuberculosis Eis protein initiates modulation of host immune responses by acetylation of DUSP16/MKP-7 Classification TRANSFERASE Compound Enhanced intracellular survival protein Source Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155) (A0QY29_MYCS2) Sequence A:  MITPRTLHTITDDDWTRIALLARFAFGDIEPEQTQAAWRS MVPEDATVVVPDETDDAFVGQSLYLDMQLTVPGGEVLPVA GISFVAVAPTHRRRGVLRAMYTELHDRIARAGYPLAVLTA SEGGIYGRFGYGVATIEQHVSVDRRLAQFHPAAPDPGGVR MLVPADHRDGLADIYDRWRRRTPGGLVRPDALWDDLLADR PESRRGGGELFAFGHQDGYALYRVDRGPDGRRSAHVVELT AVTADAHAALWRALLGLDLIDRVSIGTHPHDPLPYLLTDP RQAQVTASADDLWIRIMNVPAALEARRYQADLDVVLDVAD GFRSDGGRFALQISGGRARCTTTDAPADIEIDLDVLGGLY LGAHRVDGFAAANRLRSKDSELLQQFGAAFAGDMPAELGY GF B:  MITPRTLHTITDDDWTRIALLARFAFGDIEPEQTQAAWRS MVPEDATVVVPDETDDAFVGQSLYLDMQLTVPGGEVLPVA GISFVAVAPTHRRRGVLRAMYTELHDRIARAGYPLAVLTA SEGGIYGRFGYGVATIEQHVSVDRRLAQFHPAAPDPGGVR MLVPADHRDGLADIYDRWRRRTPGGLVRPDALWDDLLADR PESRRGGGELFAFGHQDGYALYRVDRGPDGRRSAHVVELT AVTADAHAALWRALLGLDLIDRVSIGTHPHDPLPYLLTDP RQAQVTASADDLWIRIMNVPAALEARRYQADLDVVLDVAD GFRSDGGRFALQISGGRARCTTTDAPADIEIDLDVLGGLY LGAHRVDGFAAANRLRSKDSELLQQFGAAFAGDMPAELGY GF C:  MITPRTLHTITDDDWTRIALLARFAFGDIEPEQTQAAWRS MVPEDATVVVPDETDDAFVGQSLYLDMQLTVPGGEVLPVA GISFVAVAPTHRRRGVLRAMYTELHDRIARAGYPLAVLTA SEGGIYGRFGYGVATIEQHVSVDRRLAQFHPAAPDPGGVR MLVPADHRDGLADIYDRWRRRTPGGLVRPDALWDDLLADR PESRRGGGELFAFGHQDGYALYRVDRGPDGRRSAHVVELT AVTADAHAALWRALLGLDLIDRVSIGTHPHDPLPYLLTDP RQAQVTASADDLWIRIMNVPAALEARRYQADLDVVLDVAD GFRSDGGRFALQISGGRARCTTTDAPADIEIDLDVLGGLY LGAHRVDGFAAANRLRSKDSELLQQFGAAFAGDMPAELGY GF D:  MITPRTLHTITDDDWTRIALLARFAFGDIEPEQTQAAWRS MVPEDATVVVPDETDDAFVGQSLYLDMQLTVPGGEVLPVA GISFVAVAPTHRRRGVLRAMYTELHDRIARAGYPLAVLTA SEGGIYGRFGYGVATIEQHVSVDRRLAQFHPAAPDPGGVR MLVPADHRDGLADIYDRWRRRTPGGLVRPDALWDDLLADR PESRRGGGELFAFGHQDGYALYRVDRGPDGRRSAHVVELT AVTADAHAALWRALLGLDLIDRVSIGTHPHDPLPYLLTDP RQAQVTASADDLWIRIMNVPAALEARRYQADLDVVLDVAD GFRSDGGRFALQISGGRARCTTTDAPADIEIDLDVLGGLY LGAHRVDGFAAANRLRSKDSELLQQFGAAFAGDMPAELGY GF E:  MITPRTLHTITDDDWTRIALLARFAFGDIEPEQTQAAWRS MVPEDATVVVPDETDDAFVGQSLYLDMQLTVPGGEVLPVA GISFVAVAPTHRRRGVLRAMYTELHDRIARAGYPLAVLTA SEGGIYGRFGYGVATIEQHVSVDRRLAQFHPAAPDPGGVR MLVPADHRDGLADIYDRWRRRTPGGLVRPDALWDDLLADR PESRRGGGELFAFGHQDGYALYRVDRGPDGRRSAHVVELT AVTADAHAALWRALLGLDLIDRVSIGTHPHDPLPYLLTDP RQAQVTASADDLWIRIMNVPAALEARRYQADLDVVLDVAD GFRSDGGRFALQISGGRARCTTTDAPADIEIDLDVLGGLY LGAHRVDGFAAANRLRSKDSELLQQFGAAFAGDMPAELGY GF F:  MITPRTLHTITDDDWTRIALLARFAFGDIEPEQTQAAWRS MVPEDATVVVPDETDDAFVGQSLYLDMQLTVPGGEVLPVA GISFVAVAPTHRRRGVLRAMYTELHDRIARAGYPLAVLTA SEGGIYGRFGYGVATIEQHVSVDRRLAQFHPAAPDPGGVR MLVPADHRDGLADIYDRWRRRTPGGLVRPDALWDDLLADR PESRRGGGELFAFGHQDGYALYRVDRGPDGRRSAHVVELT AVTADAHAALWRALLGLDLIDRVSIGTHPHDPLPYLLTDP RQAQVTASADDLWIRIMNVPAALEARRYQADLDVVLDVAD GFRSDGGRFALQISGGRARCTTTDAPADIEIDLDVLGGLY LGAHRVDGFAAANRLRSKDSELLQQFGAAFAGDMPAELGY GF Description Functional site 1) chain A residue 26 type sequence F description BINDING SITE FOR RESIDUE COA A 500 source : AC1 2) chain A residue 85 type sequence V description BINDING SITE FOR RESIDUE COA A 500 source : AC1 3) chain A residue 86 type sequence A description BINDING SITE FOR RESIDUE COA A 500 source : AC1 4) chain A residue 87 type sequence V description BINDING SITE FOR RESIDUE COA A 500 source : AC1 5) chain A residue 92 type sequence R description BINDING SITE FOR RESIDUE COA A 500 source : AC1 6) chain A residue 93 type sequence R description BINDING SITE FOR RESIDUE COA A 500 source : AC1 7) chain A residue 94 type sequence R description BINDING SITE FOR RESIDUE COA A 500 source : AC1 8) chain A residue 95 type sequence G description BINDING SITE FOR RESIDUE COA A 500 source : AC1 9) chain A residue 96 type sequence V description BINDING SITE FOR RESIDUE COA A 500 source : AC1 10) chain A residue 97 type sequence L description BINDING SITE FOR RESIDUE COA A 500 source : AC1 11) chain A residue 98 type sequence R description BINDING SITE FOR RESIDUE COA A 500 source : AC1 12) chain A residue 119 type sequence T description BINDING SITE FOR RESIDUE COA A 500 source : AC1 13) chain A residue 121 type sequence S description BINDING SITE FOR RESIDUE COA A 500 source : AC1 14) chain A residue 122 type sequence E description BINDING SITE FOR RESIDUE COA A 500 source : AC1 15) chain A residue 124 type sequence G description BINDING SITE FOR RESIDUE COA A 500 source : AC1 16) chain A residue 125 type sequence I description BINDING SITE FOR RESIDUE COA A 500 source : AC1 17) chain A residue 126 type sequence Y description BINDING SITE FOR RESIDUE COA A 500 source : AC1 18) chain A residue 128 type sequence R description BINDING SITE FOR RESIDUE COA A 500 source : AC1 19) chain F residue 258 type sequence D description BINDING SITE FOR RESIDUE COA A 500 source : AC1 20) chain B residue 26 type sequence F description BINDING SITE FOR RESIDUE COA B 500 source : AC2 21) chain B residue 85 type sequence V description BINDING SITE FOR RESIDUE COA B 500 source : AC2 22) chain B residue 86 type sequence A description BINDING SITE FOR RESIDUE COA B 500 source : AC2 23) chain B residue 87 type sequence V description BINDING SITE FOR RESIDUE COA B 500 source : AC2 24) chain B residue 92 type sequence R description BINDING SITE FOR RESIDUE COA B 500 source : AC2 25) chain B residue 93 type sequence R description BINDING SITE FOR RESIDUE COA B 500 source : AC2 26) chain B residue 94 type sequence R description BINDING SITE FOR RESIDUE COA B 500 source : AC2 27) chain B residue 95 type sequence G description BINDING SITE FOR RESIDUE COA B 500 source : AC2 28) chain B residue 96 type sequence V description BINDING SITE FOR RESIDUE COA B 500 source : AC2 29) chain B residue 97 type sequence L description BINDING SITE FOR RESIDUE COA B 500 source : AC2 30) chain B residue 98 type sequence R description BINDING SITE FOR RESIDUE COA B 500 source : AC2 31) chain B residue 119 type sequence T description BINDING SITE FOR RESIDUE COA B 500 source : AC2 32) chain B residue 121 type sequence S description BINDING SITE FOR RESIDUE COA B 500 source : AC2 33) chain B residue 122 type sequence E description BINDING SITE FOR RESIDUE COA B 500 source : AC2 34) chain B residue 124 type sequence G description BINDING SITE FOR RESIDUE COA B 500 source : AC2 35) chain B residue 125 type sequence I description BINDING SITE FOR RESIDUE COA B 500 source : AC2 36) chain B residue 126 type sequence Y description BINDING SITE FOR RESIDUE COA B 500 source : AC2 37) chain B residue 128 type sequence R description BINDING SITE FOR RESIDUE COA B 500 source : AC2 38) chain D residue 258 type sequence D description BINDING SITE FOR RESIDUE COA B 500 source : AC2 39) chain A residue 258 type sequence D description BINDING SITE FOR RESIDUE COA C 500 source : AC3 40) chain C residue 26 type sequence F description BINDING SITE FOR RESIDUE COA C 500 source : AC3 41) chain C residue 85 type sequence V description BINDING SITE FOR RESIDUE COA C 500 source : AC3 42) chain C residue 86 type sequence A description BINDING SITE FOR RESIDUE COA C 500 source : AC3 43) chain C residue 87 type sequence V description BINDING SITE FOR RESIDUE COA C 500 source : AC3 44) chain C residue 92 type sequence R description BINDING SITE FOR RESIDUE COA C 500 source : AC3 45) chain C residue 93 type sequence R description BINDING SITE FOR RESIDUE COA C 500 source : AC3 46) chain C residue 94 type sequence R description BINDING SITE FOR RESIDUE COA C 500 source : AC3 47) chain C residue 95 type sequence G description BINDING SITE FOR RESIDUE COA C 500 source : AC3 48) chain C residue 96 type sequence V description BINDING SITE FOR RESIDUE COA C 500 source : AC3 49) chain C residue 97 type sequence L description BINDING SITE FOR RESIDUE COA C 500 source : AC3 50) chain C residue 98 type sequence R description BINDING SITE FOR RESIDUE COA C 500 source : AC3 51) chain C residue 119 type sequence T description BINDING SITE FOR RESIDUE COA C 500 source : AC3 52) chain C residue 121 type sequence S description BINDING SITE FOR RESIDUE COA C 500 source : AC3 53) chain C residue 122 type sequence E description BINDING SITE FOR RESIDUE COA C 500 source : AC3 54) chain C residue 124 type sequence G description BINDING SITE FOR RESIDUE COA C 500 source : AC3 55) chain C residue 125 type sequence I description BINDING SITE FOR RESIDUE COA C 500 source : AC3 56) chain C residue 126 type sequence Y description BINDING SITE FOR RESIDUE COA C 500 source : AC3 57) chain C residue 128 type sequence R description BINDING SITE FOR RESIDUE COA C 500 source : AC3 58) chain D residue 25 type sequence A description BINDING SITE FOR RESIDUE COA D 500 source : AC4 59) chain D residue 26 type sequence F description BINDING SITE FOR RESIDUE COA D 500 source : AC4 60) chain D residue 85 type sequence V description BINDING SITE FOR RESIDUE COA D 500 source : AC4 61) chain D residue 86 type sequence A description BINDING SITE FOR RESIDUE COA D 500 source : AC4 62) chain D residue 87 type sequence V description BINDING SITE FOR RESIDUE COA D 500 source : AC4 63) chain D residue 92 type sequence R description BINDING SITE FOR RESIDUE COA D 500 source : AC4 64) chain D residue 93 type sequence R description BINDING SITE FOR RESIDUE COA D 500 source : AC4 65) chain D residue 94 type sequence R description BINDING SITE FOR RESIDUE COA D 500 source : AC4 66) chain D residue 95 type sequence G description BINDING SITE FOR RESIDUE COA D 500 source : AC4 67) chain D residue 96 type sequence V description BINDING SITE FOR RESIDUE COA D 500 source : AC4 68) chain D residue 97 type sequence L description BINDING SITE FOR RESIDUE COA D 500 source : AC4 69) chain D residue 98 type sequence R description BINDING SITE FOR RESIDUE COA D 500 source : AC4 70) chain D residue 119 type sequence T description BINDING SITE FOR RESIDUE COA D 500 source : AC4 71) chain D residue 121 type sequence S description BINDING SITE FOR RESIDUE COA D 500 source : AC4 72) chain D residue 122 type sequence E description BINDING SITE FOR RESIDUE COA D 500 source : AC4 73) chain D residue 124 type sequence G description BINDING SITE FOR RESIDUE COA D 500 source : AC4 74) chain D residue 125 type sequence I description BINDING SITE FOR RESIDUE COA D 500 source : AC4 75) chain D residue 126 type sequence Y description BINDING SITE FOR RESIDUE COA D 500 source : AC4 76) chain D residue 128 type sequence R description BINDING SITE FOR RESIDUE COA D 500 source : AC4 77) chain E residue 258 type sequence D description BINDING SITE FOR RESIDUE COA D 500 source : AC4 78) chain B residue 258 type sequence D description BINDING SITE FOR RESIDUE COA E 500 source : AC5 79) chain E residue 26 type sequence F description BINDING SITE FOR RESIDUE COA E 500 source : AC5 80) chain E residue 85 type sequence V description BINDING SITE FOR RESIDUE COA E 500 source : AC5 81) chain E residue 87 type sequence V description BINDING SITE FOR RESIDUE COA E 500 source : AC5 82) chain E residue 92 type sequence R description BINDING SITE FOR RESIDUE COA E 500 source : AC5 83) chain E residue 93 type sequence R description BINDING SITE FOR RESIDUE COA E 500 source : AC5 84) chain E residue 94 type sequence R description BINDING SITE FOR RESIDUE COA E 500 source : AC5 85) chain E residue 95 type sequence G description BINDING SITE FOR RESIDUE COA E 500 source : AC5 86) chain E residue 96 type sequence V description BINDING SITE FOR RESIDUE COA E 500 source : AC5 87) chain E residue 97 type sequence L description BINDING SITE FOR RESIDUE COA E 500 source : AC5 88) chain E residue 98 type sequence R description BINDING SITE FOR RESIDUE COA E 500 source : AC5 89) chain E residue 119 type sequence T description BINDING SITE FOR RESIDUE COA E 500 source : AC5 90) chain E residue 121 type sequence S description BINDING SITE FOR RESIDUE COA E 500 source : AC5 91) chain E residue 122 type sequence E description BINDING SITE FOR RESIDUE COA E 500 source : AC5 92) chain E residue 124 type sequence G description BINDING SITE FOR RESIDUE COA E 500 source : AC5 93) chain E residue 125 type sequence I description BINDING SITE FOR RESIDUE COA E 500 source : AC5 94) chain E residue 126 type sequence Y description BINDING SITE FOR RESIDUE COA E 500 source : AC5 95) chain E residue 128 type sequence R description BINDING SITE FOR RESIDUE COA E 500 source : AC5 96) chain C residue 258 type sequence D description BINDING SITE FOR RESIDUE COA F 500 source : AC6 97) chain F residue 26 type sequence F description BINDING SITE FOR RESIDUE COA F 500 source : AC6 98) chain F residue 85 type sequence V description BINDING SITE FOR RESIDUE COA F 500 source : AC6 99) chain F residue 86 type sequence A description BINDING SITE FOR RESIDUE COA F 500 source : AC6 100) chain F residue 87 type sequence V description BINDING SITE FOR RESIDUE COA F 500 source : AC6 101) chain F residue 92 type sequence R description BINDING SITE FOR RESIDUE COA F 500 source : AC6 102) chain F residue 93 type sequence R description BINDING SITE FOR RESIDUE COA F 500 source : AC6 103) chain F residue 94 type sequence R description BINDING SITE FOR RESIDUE COA F 500 source : AC6 104) chain F residue 95 type sequence G description BINDING SITE FOR RESIDUE COA F 500 source : AC6 105) chain F residue 96 type sequence V description BINDING SITE FOR RESIDUE COA F 500 source : AC6 106) chain F residue 97 type sequence L description BINDING SITE FOR RESIDUE COA F 500 source : AC6 107) chain F residue 98 type sequence R description BINDING SITE FOR RESIDUE COA F 500 source : AC6 108) chain F residue 121 type sequence S description BINDING SITE FOR RESIDUE COA F 500 source : AC6 109) chain F residue 122 type sequence E description BINDING SITE FOR RESIDUE COA F 500 source : AC6 110) chain F residue 124 type sequence G description BINDING SITE FOR RESIDUE COA F 500 source : AC6 111) chain F residue 125 type sequence I description BINDING SITE FOR RESIDUE COA F 500 source : AC6 112) chain F residue 126 type sequence Y description BINDING SITE FOR RESIDUE COA F 500 source : AC6 113) chain F residue 128 type sequence R description BINDING SITE FOR RESIDUE COA F 500 source : AC6

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