eF-site ID 3sxf-A PDB Code 3sxf Chain A click to enlarge Title Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with Bumped Kinase Inhibitor, RM-1-89 Classification transferase/transferase inhibitor Compound Calmodulin-domain protein kinase 1 Source Toxoplasma gondii (Q9BJF5_TOXGO) Sequence A:  AIFSDRYKGQRVLGKGSFGEVILCKDKITGQECAVKVISK RQVKQKTDKESLLREVQLLKQLDHPNIMKLYEFFEDKGYF YLVGEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITY MHKNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEA SKKMKDKIGTAYYIAPEVLHGTYDEKCDVWSTGVILYILL SGCPPFNGANEYDILKKVEKGKYTFELPQWKKVSESAKDL IRKMLTYVPSMRISARDALDHEWIQTYTKEQISVDVPSLD NAILNIRQFQGTQKLAQAALLYMGSKLTSQDETKELTAIF HKMDKNGDGQLDRAELIEGYKELMRMAVEHEVDQVLDAVD FDKNGYIEYSEFVTVAMDRKTLLSRERLERAFRMFDSDNS GKISSTELATIFGVSDVDSETWKSVLSEVDKNNDGEVDFD EFQQMLLKLCGN Description Functional site 1) chain A residue 65 type sequence V description BINDING SITE FOR RESIDUE BK5 A 701 source : AC1 2) chain A residue 78 type sequence A description BINDING SITE FOR RESIDUE BK5 A 701 source : AC1 3) chain A residue 80 type sequence K description BINDING SITE FOR RESIDUE BK5 A 701 source : AC1 4) chain A residue 112 type sequence M description BINDING SITE FOR RESIDUE BK5 A 701 source : AC1 5) chain A residue 126 type sequence L description BINDING SITE FOR RESIDUE BK5 A 701 source : AC1 6) chain A residue 129 type sequence E description BINDING SITE FOR RESIDUE BK5 A 701 source : AC1 7) chain A residue 131 type sequence Y description BINDING SITE FOR RESIDUE BK5 A 701 source : AC1 8) chain A residue 195 type sequence D description BINDING SITE FOR RESIDUE BK5 A 701 source : AC1 9) chain A residue 267 type sequence Y description BINDING SITE FOR RESIDUE DMS A 711 source : AC2 10) chain A residue 268 type sequence T description BINDING SITE FOR RESIDUE DMS A 711 source : AC2 11) chain A residue 269 type sequence F description BINDING SITE FOR RESIDUE DMS A 711 source : AC2 12) chain A residue 286 type sequence R description BINDING SITE FOR RESIDUE DMS A 711 source : AC2 13) chain A residue 419 type sequence N description BINDING SITE FOR RESIDUE DMS A 711 source : AC2 14) chain A residue 420 type sequence G description BINDING SITE FOR RESIDUE DMS A 711 source : AC2 15) chain A residue 421 type sequence Y description BINDING SITE FOR RESIDUE DMS A 711 source : AC2 16) chain A residue 211 type sequence K description BINDING SITE FOR RESIDUE EDO A 712 source : AC3 17) chain A residue 213 type sequence G description BINDING SITE FOR RESIDUE EDO A 712 source : AC3 18) chain A residue 214 type sequence T description BINDING SITE FOR RESIDUE EDO A 712 source : AC3 19) chain A residue 215 type sequence A description BINDING SITE FOR RESIDUE EDO A 712 source : AC3 20) chain A residue 469 type sequence V description BINDING SITE FOR RESIDUE EDO A 712 source : AC3 21) chain A residue 57-80 type prosite sequence LGKGSFGEVILCKDKITGQECAVK description PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGKGSFGEVIlCkdkitgqe..........CAVK source prosite : PS00107 22) chain A residue 368-380 type prosite sequence DKNGDGQLDRAEL description EF_HAND_1 EF-hand calcium-binding domain. DKNGDGQLDraEL source prosite : PS00018 23) chain A residue 415-427 type prosite sequence DFDKNGYIEYSEF description EF_HAND_1 EF-hand calcium-binding domain. DKNGDGQLDraEL source prosite : PS00018 24) chain A residue 451-463 type prosite sequence DSDNSGKISSTEL description EF_HAND_1 EF-hand calcium-binding domain. DKNGDGQLDraEL source prosite : PS00018 25) chain A residue 485-497 type prosite sequence DKNNDGEVDFDEF description EF_HAND_1 EF-hand calcium-binding domain. DKNGDGQLDraEL source prosite : PS00018 26) chain A residue 170-182 type prosite sequence IVHRDLKPENLLL description PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IvHrDLKpeNLLL source prosite : PS00108

Display surface Download Links