eF-site ID 3svh-AB PDB Code 3svh Chain A, B click to enlarge Title Crystal Structure of the bromdomain of human CREBBP in complex with a 3,5-dimethylisoxazol ligand Classification UNKNOWN FUNCTION Compound CREB-binding protein Source Homo sapiens (Human) (CBP_HUMAN) Sequence A:  RKKIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLL GIPDYFDIVKNPMDLSTIKRKLDTGQYQEPWQYVDDVWLM FNNAWLYNRKTSRVYKFCSKLAEVFEQEIDPVMQSLG B:  RKKIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLL GIPDYFDIVKNPMDLSTIKRKLDTGQYQEPWQYVDDVWLM FNNAWLYNRKTSRVYKFCSKLAEVFEQEIDPVMQSLG Description Functional site 1) chain A residue 1091 type sequence R description BINDING SITE FOR RESIDUE KRG A 1 source : AC1 2) chain A residue 1095 type sequence M description BINDING SITE FOR RESIDUE KRG A 1 source : AC1 3) chain A residue 1099 type sequence E description BINDING SITE FOR RESIDUE KRG A 1 source : AC1 4) chain A residue 1102 type sequence Y description BINDING SITE FOR RESIDUE KRG A 1 source : AC1 5) chain A residue 1139 type sequence K description BINDING SITE FOR RESIDUE KRG A 1 source : AC1 6) chain B residue 1151 type sequence W description BINDING SITE FOR RESIDUE KRG A 1 source : AC1 7) chain B residue 1154 type sequence V description BINDING SITE FOR RESIDUE KRG A 1 source : AC1 8) chain B residue 1158 type sequence W description BINDING SITE FOR RESIDUE KRG A 1 source : AC1 9) chain B residue 1185 type sequence F description BINDING SITE FOR RESIDUE KRG A 1 source : AC1 10) chain B residue 1186 type sequence E description BINDING SITE FOR RESIDUE KRG A 1 source : AC1 11) chain B residue 1193 type sequence M description BINDING SITE FOR RESIDUE KRG A 1 source : AC1 12) chain A residue 1110 type sequence P description BINDING SITE FOR RESIDUE KRG A 2 source : AC2 13) chain A residue 1113 type sequence Q description BINDING SITE FOR RESIDUE KRG A 2 source : AC2 14) chain A residue 1115 type sequence V description BINDING SITE FOR RESIDUE KRG A 2 source : AC2 15) chain A residue 1122 type sequence I description BINDING SITE FOR RESIDUE KRG A 2 source : AC2 16) chain A residue 1168 type sequence N description BINDING SITE FOR RESIDUE KRG A 2 source : AC2 17) chain A residue 1174 type sequence V description BINDING SITE FOR RESIDUE KRG A 2 source : AC2 18) chain A residue 1103 type sequence R description BINDING SITE FOR RESIDUE EDO A 1198 source : AC3 19) chain A residue 1112 type sequence R description BINDING SITE FOR RESIDUE EDO A 1198 source : AC3 20) chain B residue 1151 type sequence W description BINDING SITE FOR RESIDUE EDO A 1198 source : AC3 21) chain B residue 1197 type sequence G description BINDING SITE FOR RESIDUE EDO A 1198 source : AC3 22) chain A residue 1151 type sequence W description BINDING SITE FOR RESIDUE KRG B 2 source : AC4 23) chain A residue 1154 type sequence V description BINDING SITE FOR RESIDUE KRG B 2 source : AC4 24) chain A residue 1158 type sequence W description BINDING SITE FOR RESIDUE KRG B 2 source : AC4 25) chain A residue 1185 type sequence F description BINDING SITE FOR RESIDUE KRG B 2 source : AC4 26) chain A residue 1186 type sequence E description BINDING SITE FOR RESIDUE KRG B 2 source : AC4 27) chain A residue 1193 type sequence M description BINDING SITE FOR RESIDUE KRG B 2 source : AC4 28) chain B residue 1091 type sequence R description BINDING SITE FOR RESIDUE KRG B 2 source : AC4 29) chain B residue 1095 type sequence M description BINDING SITE FOR RESIDUE KRG B 2 source : AC4 30) chain B residue 1099 type sequence E description BINDING SITE FOR RESIDUE KRG B 2 source : AC4 31) chain B residue 1102 type sequence Y description BINDING SITE FOR RESIDUE KRG B 2 source : AC4 32) chain B residue 1139 type sequence K description BINDING SITE FOR RESIDUE KRG B 2 source : AC4 33) chain B residue 1110 type sequence P description BINDING SITE FOR RESIDUE KRG B 1 source : AC5 34) chain B residue 1113 type sequence Q description BINDING SITE FOR RESIDUE KRG B 1 source : AC5 35) chain B residue 1115 type sequence V description BINDING SITE FOR RESIDUE KRG B 1 source : AC5 36) chain B residue 1120 type sequence L description BINDING SITE FOR RESIDUE KRG B 1 source : AC5 37) chain B residue 1122 type sequence I description BINDING SITE FOR RESIDUE KRG B 1 source : AC5 38) chain B residue 1168 type sequence N description BINDING SITE FOR RESIDUE KRG B 1 source : AC5 39) chain B residue 1174 type sequence V description BINDING SITE FOR RESIDUE KRG B 1 source : AC5 40) chain A residue 1108-1167 type prosite sequence SLPFRQPVDPQLLGIPDYFDIVKNPMDLSTIKRKLDTGQY QEPWQYVDDVWLMFNNAWLY description BROMODOMAIN_1 Bromodomain signature. SlpFrqpvDpqllgipDYFdiVknpMdlstIkrkldtgq..Yqepwqyvddvwl.MfnNAwlY source prosite : PS00633

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