eF-site ID 3sn8-A PDB Code 3sn8 Chain A click to enlarge Title Crystal structure of SARS coronavirus main protease complexed with Cm-FF-H (soaking) Classification HYDROLASE/HYDROLASE INHIBITOR Compound 3C-like proteinase Source Human SARS coronavirus (SARS-CoV) (Severe acute respiratory syndrome coronavirus) (R1A_CVHSA) Sequence A:  SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDTVYCPR HVICTAEDMLNPNYEDLLIRKSNHSFLVQAGNVQLRVIGH SMQNCLLRLKVDTSNPKTPKYKFVRIQPGQTFSVLACYNG SPSGVYQCAMRPNHTIKGSFLNGSCGSVGFNIDYDCVSFC YMHHMELPTGVHAGTDLEGKFYGPFVDRQTAQAAGTDTTI TLNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYE PLTQDHVDILGPLSAQTGIAVLDMCAALKELLQNGMNGRT ILGSTILEDEFTPFDVVRQCSGVTFQ Description (1)  3C-like proteinase (E.C.3.4.22.-) Functional site 1) chain A residue 49 type sequence M description BINDING SITE FOR RESIDUE S89 A 307 source : AC1 2) chain A residue 140 type sequence F description BINDING SITE FOR RESIDUE S89 A 307 source : AC1 3) chain A residue 141 type sequence L description BINDING SITE FOR RESIDUE S89 A 307 source : AC1 4) chain A residue 142 type sequence N description BINDING SITE FOR RESIDUE S89 A 307 source : AC1 5) chain A residue 143 type sequence G description BINDING SITE FOR RESIDUE S89 A 307 source : AC1 6) chain A residue 144 type sequence S description BINDING SITE FOR RESIDUE S89 A 307 source : AC1 7) chain A residue 145 type sequence C description BINDING SITE FOR RESIDUE S89 A 307 source : AC1 8) chain A residue 165 type sequence M description BINDING SITE FOR RESIDUE S89 A 307 source : AC1 9) chain A residue 166 type sequence E description BINDING SITE FOR RESIDUE S89 A 307 source : AC1 10) chain A residue 188 type sequence R description BINDING SITE FOR RESIDUE S89 A 307 source : AC1 11) chain A residue 189 type sequence Q description BINDING SITE FOR RESIDUE S89 A 307 source : AC1 12) chain A residue 41 type ACT_SITE sequence H description For 3CL-PRO activity => ECO:0000255|PROSITE-ProRule:PRU00772, ECO:0000269|PubMed:16306590 source Swiss-Prot : SWS_FT_FI1 13) chain A residue 145 type ACT_SITE sequence C description For 3CL-PRO activity => ECO:0000255|PROSITE-ProRule:PRU00772 source Swiss-Prot : SWS_FT_FI2 14) chain A residue 306 type SITE sequence Q description Cleavage; by 3CL-PRO => ECO:0000269|PubMed:14561748 source Swiss-Prot : SWS_FT_FI3

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