eF-site ID 3skh-B PDB Code 3skh Chain B click to enlarge Title I. Novel HCV NS5B Polymerase Inhibitors: Discovery of Indole 2- Carboxylic Acids with C3-Heterocycles Classification transferase/transferase INHIBITOR Compound HCV NS5B RNA_DEPENDENT RNA POLYMERASE Source Hepatitis C virus genotype 1b (strain HC-J4) (HCV) (POLG_HCVJ4) Sequence B:  SMSYTWTGALITPCAAEESKLPINPLSNSLLRHHNMVYAT TSRSASLRQKKVTFDRLQVLDDHYRDVLKEMKAKASTVKA KLLSIEEACKLTPPHSAKSKFGYGAKDVRNLSSRAVNHIR SVWEDLLEDTETPIDTTIMAKSEVFCVQRKPARLIVFPDL GVRVCEKMALYDVVSTLPQAVMGSSYGFQYSPKQRVEFLV NTWKSKKCPMGFSYDTRCFDSTVTESDIRVEESIYQCCDL APEARQAIRSLTERLYIGGPLTNSKGQNCGYRRCRASGVL TTSCGNTLTCYLKATAACRAAKLQDCTMLVNGDDLVVICE SAGTQEDAAALRAFTEAMTRYSAPPGDPPQPEYDLELITS CSSNVSVAHDASGKRVYYLTRDPTTPLARAAWETARHTPI NSWLGNIIMYAPTLWARMILMTHFFSILLAQEQLGKALDC QIYGACYSIEPLDLPQIIERLHGLSAFTLHSYSPGEINRV ASCLRKLGVPPLRTWRHRARSVRAKLLSQGGRAAICGRYL FNWAVRTKLKLTPIPAASQLDLSGWFVAGYSGGDIYHS Description Functional site 1) chain B residue 366 type sequence C description BINDING SITE FOR RESIDUE 058 B 577 source : AC2 2) chain B residue 410 type sequence G description BINDING SITE FOR RESIDUE 058 B 577 source : AC2 3) chain B residue 414 type sequence M description BINDING SITE FOR RESIDUE 058 B 577 source : AC2 4) chain B residue 415 type sequence Y description BINDING SITE FOR RESIDUE 058 B 577 source : AC2 5) chain B residue 446 type sequence Q description BINDING SITE FOR RESIDUE 058 B 577 source : AC2 6) chain B residue 447 type sequence I description BINDING SITE FOR RESIDUE 058 B 577 source : AC2 7) chain B residue 448 type sequence Y description BINDING SITE FOR RESIDUE 058 B 577 source : AC2 8) chain B residue 220 type BINDING sequence D description BINDING => ECO:0000250|UniProtKB:P26663 source Swiss-Prot : SWS_FT_FI1 9) chain B residue 318 type BINDING sequence D description BINDING => ECO:0000250|UniProtKB:P26663 source Swiss-Prot : SWS_FT_FI1 10) chain B residue 319 type BINDING sequence D description BINDING => ECO:0000250|UniProtKB:P26663 source Swiss-Prot : SWS_FT_FI1 11) chain B residue 29 type MOD_RES sequence S description Phosphoserine; by host => ECO:0000250|UniProtKB:P26662 source Swiss-Prot : SWS_FT_FI2 12) chain B residue 42 type MOD_RES sequence S description Phosphoserine; by host => ECO:0000250|UniProtKB:P26662 source Swiss-Prot : SWS_FT_FI2

Display surface Download Links