eF-site ID 3skh-A PDB Code 3skh Chain A click to enlarge Title I. Novel HCV NS5B Polymerase Inhibitors: Discovery of Indole 2- Carboxylic Acids with C3-Heterocycles Classification transferase/transferase INHIBITOR Compound HCV NS5B RNA_DEPENDENT RNA POLYMERASE Source Hepatitis C virus genotype 1b (strain HC-J4) (HCV) (POLG_HCVJ4) Sequence A:  SMSYTWTGALITPCAAEESKLPINPLSNSLLRHHNMVYAT TSRSASLRQKKVTFDRLQVLDDHYRDVLKEMKAKASTVKA KLLSIEEACKLTPPHSAKSKFGYGAKDVRNLSSRAVNHIR SVWEDLLEDTETPIDTTIMAKSEVFCVQRKPARLIVFPDL GVRVCEKMALYDVVSTLPQAVMGSSYGFQYSPKQRVEFLV NTWKSKKCPMGFSYDTRCFDSTVTESDIRVEESIYQCCDL APEARQAIRSLTERLYIGGPLTNSKGQNCGYRRCRASGVL TTSCGNTLTCYLKATAACRAAKLQDCTMLVNGDDLVVICE SAGTQEDAAALRAFTEAMTRYSAPPGDPPQPEYDLELITS CSSNVSVAHDASGKRVYYLTRDPTTPLARAAWETARHTPI NSWLGNIIMYAPTLWARMILMTHFFSILLAQEQLGKALDC QIYGACYSIEPLDLPQIIERLHGLSAFTLHSYSPGEINRV ASCLRKLGVPPLRTWRHRARSVRAKLLSQGGRAAICGRYL FNWAVRTKLKLTPIPAASQLDLSGWFVAGYSGGDIYHS Description Functional site 1) chain A residue 316 type sequence N description BINDING SITE FOR RESIDUE 058 A 577 source : AC1 2) chain A residue 366 type sequence C description BINDING SITE FOR RESIDUE 058 A 577 source : AC1 3) chain A residue 368 type sequence S description BINDING SITE FOR RESIDUE 058 A 577 source : AC1 4) chain A residue 410 type sequence G description BINDING SITE FOR RESIDUE 058 A 577 source : AC1 5) chain A residue 411 type sequence N description BINDING SITE FOR RESIDUE 058 A 577 source : AC1 6) chain A residue 414 type sequence M description BINDING SITE FOR RESIDUE 058 A 577 source : AC1 7) chain A residue 415 type sequence Y description BINDING SITE FOR RESIDUE 058 A 577 source : AC1 8) chain A residue 446 type sequence Q description BINDING SITE FOR RESIDUE 058 A 577 source : AC1 9) chain A residue 447 type sequence I description BINDING SITE FOR RESIDUE 058 A 577 source : AC1 10) chain A residue 448 type sequence Y description BINDING SITE FOR RESIDUE 058 A 577 source : AC1 11) chain A residue 220 type BINDING sequence D description BINDING => ECO:0000250|UniProtKB:P26663 source Swiss-Prot : SWS_FT_FI1 12) chain A residue 318 type BINDING sequence D description BINDING => ECO:0000250|UniProtKB:P26663 source Swiss-Prot : SWS_FT_FI1 13) chain A residue 319 type BINDING sequence D description BINDING => ECO:0000250|UniProtKB:P26663 source Swiss-Prot : SWS_FT_FI1 14) chain A residue 29 type MOD_RES sequence S description Phosphoserine; by host => ECO:0000250|UniProtKB:P26662 source Swiss-Prot : SWS_FT_FI2 15) chain A residue 42 type MOD_RES sequence S description Phosphoserine; by host => ECO:0000250|UniProtKB:P26662 source Swiss-Prot : SWS_FT_FI2

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