eF-site ID 3ske-B PDB Code 3ske Chain B click to enlarge Title I. Novel HCV NS5B Polymerase Inhibitors: Discovery of Indole 2- Carboxylic Acids with C3-Heterocycles Classification transferase/transferase INHIBITOR Compound HCV NS5B RNA_DEPENDENT RNA POLYMERASE Source Hepatitis C virus genotype 1b (strain HC-J4) (HCV) (POLG_HCVJ4) Sequence B:  SMSYTWTGALITPCAAEESKLPINPLSNSLLRHHNMVYAT TSRSASLRQKKVTFDRLQVLDDHYRDVLKEMKAKASTVKA KLLSIEEACKLTPPHSAKSKFGYGAKDVRNLSSRAVNHIR SVWEDLLEDTETPIDTTIMAKSEVFCVQRKPARLIVFPDL GVRVCEKMALYDVVSTLPQAVMGSSYGFQYSPKQRVEFLV NTWKSKKCPMGFSYDTRCFDSTVTESDIRVEESIYQCCDL APEARQAIRSLTERLYIGGPLTNSKGQNCGYRRCRASGVL TTSCGNTLTCYLKATAACRAAKLQDCTMLVNGDDLVVICE SAGTQEDAAALRAFTEAMTRYSAPPGDPPQPEYDLELITS CSSNVSVAHDASGKRVYYLTRDPTTPLARAAWETARHTPI NSWLGNIIMYAPTLWARMILMTHFFSILLAQEQLGKALDC QIYGACYSIEPLDLPQIIERLHGLSAFTLHSYSPGEINRV ASCLRKLGVPPLRTWRHRARSVRAKLLSQGGRAAICGRYL FNWAVRTKLKLTPIPAASQLDLSGWFVAGYSGGDIYHS Description (1)  HCV NS5B RNA_DEPENDENT RNA POLYMERASE E.C.2.7.7.48 Functional site 1) chain B residue 197 type sequence P description BINDING SITE FOR RESIDUE 054 B 577 source : AC3 2) chain B residue 316 type sequence N description BINDING SITE FOR RESIDUE 054 B 577 source : AC3 3) chain B residue 366 type sequence C description BINDING SITE FOR RESIDUE 054 B 577 source : AC3 4) chain B residue 368 type sequence S description BINDING SITE FOR RESIDUE 054 B 577 source : AC3 5) chain B residue 384 type sequence L description BINDING SITE FOR RESIDUE 054 B 577 source : AC3 6) chain B residue 407 type sequence S description BINDING SITE FOR RESIDUE 054 B 577 source : AC3 7) chain B residue 410 type sequence G description BINDING SITE FOR RESIDUE 054 B 577 source : AC3 8) chain B residue 411 type sequence N description BINDING SITE FOR RESIDUE 054 B 577 source : AC3 9) chain B residue 414 type sequence M description BINDING SITE FOR RESIDUE 054 B 577 source : AC3 10) chain B residue 415 type sequence Y description BINDING SITE FOR RESIDUE 054 B 577 source : AC3 11) chain B residue 446 type sequence Q description BINDING SITE FOR RESIDUE 054 B 577 source : AC3 12) chain B residue 447 type sequence I description BINDING SITE FOR RESIDUE 054 B 577 source : AC3 13) chain B residue 448 type sequence Y description BINDING SITE FOR RESIDUE 054 B 577 source : AC3 14) chain B residue 42 type MOD_RES sequence S description Phosphoserine; by host => ECO:0000250|UniProtKB:P26662 source Swiss-Prot : SWS_FT_FI2 15) chain B residue 29 type MOD_RES sequence S description Phosphoserine; by host => ECO:0000250|UniProtKB:P26662 source Swiss-Prot : SWS_FT_FI2 16) chain B residue 220 type BINDING sequence D description BINDING => ECO:0000250|UniProtKB:P26663 source Swiss-Prot : SWS_FT_FI1 17) chain B residue 318 type BINDING sequence D description BINDING => ECO:0000250|UniProtKB:P26663 source Swiss-Prot : SWS_FT_FI1 18) chain B residue 319 type BINDING sequence D description BINDING => ECO:0000250|UniProtKB:P26663 source Swiss-Prot : SWS_FT_FI1

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