eF-site ID 3sga-E PDB Code 3sga Chain E click to enlarge Title STRUCTURES OF PRODUCT AND INHIBITOR COMPLEXES OF STREPTOMYCES GRISEUS PROTEASE A AT 1.8 ANGSTROMS RESOLUTION. A MODEL FOR SERINE PROTEASE CATALYSIS Classification HYDROLASE/HYDROLASE INHIBITOR Compound PROTEINASE A (SGPA) Source null (3SGA) Sequence E:  IAGGEAITTGGSRCSLGFNVSVNGVAHALTAGHCTNISAS WSIGTRTGTSFPNNDYGIIRHSNPAAADGRVYLYNGSYQD ITTAGNAFVGQAVQRSGSTTGLRSGSVTGLNATVNYGSSG IVYGMIQTNVCAQPGDSGGSLFAGSTALGLTSGGSGNCRT GGTTFYQPVTEALSAYGATVL Description (1)  PROTEINASE A (COMPONENT OF THE EXTRACELLULAR FILTRATE PRONASE) (SGPA) (E.C. NUMBER NOT ASSIGNED) COMPLEXED WITH TETRAPEPTIDE ACE-PRO-ALA-PRO-PHE-ALDEHYDE Functional site 1) chain E residue 57 type sequence H description BINDING SITE FOR CHAIN P OF ACE-PRO-ALA-PRO-PHE-ALDEHYDE source : AC1 2) chain E residue 170 type sequence N description BINDING SITE FOR CHAIN P OF ACE-PRO-ALA-PRO-PHE-ALDEHYDE source : AC1 3) chain E residue 171 type sequence Y description BINDING SITE FOR CHAIN P OF ACE-PRO-ALA-PRO-PHE-ALDEHYDE source : AC1 4) chain E residue 192 type sequence A description BINDING SITE FOR CHAIN P OF ACE-PRO-ALA-PRO-PHE-ALDEHYDE source : AC1 5) chain E residue 192 type sequence A description BINDING SITE FOR CHAIN P OF ACE-PRO-ALA-PRO-PHE-ALDEHYDE source : AC1 6) chain E residue 193 type sequence G description BINDING SITE FOR CHAIN P OF ACE-PRO-ALA-PRO-PHE-ALDEHYDE source : AC1 7) chain E residue 195 type sequence S description BINDING SITE FOR CHAIN P OF ACE-PRO-ALA-PRO-PHE-ALDEHYDE source : AC1 8) chain E residue 214 type sequence S description BINDING SITE FOR CHAIN P OF ACE-PRO-ALA-PRO-PHE-ALDEHYDE source : AC1 9) chain E residue 215 type sequence G description BINDING SITE FOR CHAIN P OF ACE-PRO-ALA-PRO-PHE-ALDEHYDE source : AC1 10) chain E residue 216 type sequence G description BINDING SITE FOR CHAIN P OF ACE-PRO-ALA-PRO-PHE-ALDEHYDE source : AC1 11) chain E residue 57 type ACT_SITE sequence H description Charge relay system => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 12) chain E residue 102 type ACT_SITE sequence D description Charge relay system => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 13) chain E residue 195 type ACT_SITE sequence S description Charge relay system => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 14) chain E residue 53-58 type prosite sequence LTAGHC description TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAGHC source prosite : PS00134 15) chain E residue 191-200 type prosite sequence CAQPGDSGGSLF description TRYPSIN_SER Serine proteases, trypsin family, serine active site. CAqpGDSGGSLF source prosite : PS00135

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