eF-site ID 3se8-GHL PDB Code 3se8 Chain G, H, L click to enlarge Title Crystal structure of broadly and potently neutralizing antibody VRC03 in complex with HIV-1 gp120 Classification VIRAL PROTEIN/IMMUNE SYSTEM Compound HIV-1 Clade AE strain 93TH057 gp120 Source (3SE8) Sequence G:  VWKDADTTLFCASDAKAHETEVHNVWATHACVPTDPNPQE IHLENVTENFNMWKNNMVEQMQEDVISLWDQSLQPCVKLT GGSVIKQACPKISFDPIPIHYCTPAGYVILKCNDKNFNGT GPCKNVSSVQCTHGIKPVVSTQLLLNGSLAEEEIIIRSEN LTNNAKTIIVHLNKSVEINCTRPSNDIRKAYCEINGTKWN KVLKQVTEKLKEHFNNKTIIFQPPSGGDLEITMHHFNCRG EFFYCNTTQLFNNTCIGNMKGCNGTITLPCKIKQIINMWQ GTGQAMYAPPIDGKINCVSNITGILLTRDGGANNTSNETF RPGGGNIKDNWRSELYKYKVVQIE H:  QVQLVQSGAVIKTPGSSVKISCRASGYNFRDYSIHWVRLI PDKGFEWIGWIKPLWGAVSYARQLQGRVSMTRQLSQDPDD PDWGVAYMEFSGLTPADTAEYFCVRRGSCDYCGDFPWQYW CQGTVVVVSSASTKGPSVFPLAPSSGGTAALGCLVKDYFP EPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSS SLGTQTYICNVNHKPSNTKVDKKVEPK L:  EIVLTQSPGILSLSPGETATLFCKASQGGNAMTWYQKRRG QVPRLLIYDTSRRASGVPDRFVGSGSGTDFFLTINKLDRE DFAVYYCQQFEFFGLGSELEVHRTVAAPSVFIFPPSDEQL KSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTE QDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPV TKSFNRGE Description (1)  HIV-1 Clade AE strain 93TH057 gp120, Heavy chain of antibody VRC03, Light chain of antibody VRC03 Functional site 1) chain L residue 192-198 type prosite sequence YACEVTH description IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH source prosite : PS00290 2) chain H residue 194-200 type prosite sequence YICNVNH description IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH source prosite : PS00290

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