eF-site ID 3s79-A PDB Code 3s79 Chain A click to enlarge Title Human placental aromatase cytochrome P450 (CYP19A1) refined at 2.75 angstrom Classification OXIDOREDUCTASE Compound Cytochrome P450 19A1 Source null (CP19A_HUMAN) Sequence A:  SSIPGPGYCMGIGPLISHGRFLWMGIGSACNYYNRVYGEF MRVWISGEETLIISKSSSMFHIMKHNHYSSRFGSKLGLQC IGMHEKGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVC AESLKTHLDRLEEVTNESGYVDVLTLLRRVMLDTSNTLFL RIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKY EKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELIL AEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAK HPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESM RYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRL EFFPKPNEFTLENFAKNVPYRYFQPFGFGPRGCAGKYIAM VMMKAILVTLLRRFHVKTLQGQCVESIQKIHDLSLHPDET KNMLEMIFTPRN Description Functional site 1) chain A residue 115 type sequence R description BINDING SITE FOR RESIDUE HEM A 600 source : AC1 2) chain A residue 132 type sequence I description BINDING SITE FOR RESIDUE HEM A 600 source : AC1 3) chain A residue 133 type sequence I description BINDING SITE FOR RESIDUE HEM A 600 source : AC1 4) chain A residue 141 type sequence W description BINDING SITE FOR RESIDUE HEM A 600 source : AC1 5) chain A residue 145 type sequence R description BINDING SITE FOR RESIDUE HEM A 600 source : AC1 6) chain A residue 306 type sequence A description BINDING SITE FOR RESIDUE HEM A 600 source : AC1 7) chain A residue 314 type sequence S description BINDING SITE FOR RESIDUE HEM A 600 source : AC1 8) chain A residue 364 type sequence M description BINDING SITE FOR RESIDUE HEM A 600 source : AC1 9) chain A residue 373 type sequence V description BINDING SITE FOR RESIDUE HEM A 600 source : AC1 10) chain A residue 375 type sequence R description BINDING SITE FOR RESIDUE HEM A 600 source : AC1 11) chain A residue 430 type sequence F description BINDING SITE FOR RESIDUE HEM A 600 source : AC1 12) chain A residue 431 type sequence G description BINDING SITE FOR RESIDUE HEM A 600 source : AC1 13) chain A residue 435 type sequence R description BINDING SITE FOR RESIDUE HEM A 600 source : AC1 14) chain A residue 436 type sequence G description BINDING SITE FOR RESIDUE HEM A 600 source : AC1 15) chain A residue 437 type sequence C description BINDING SITE FOR RESIDUE HEM A 600 source : AC1 16) chain A residue 446 type sequence M description BINDING SITE FOR RESIDUE HEM A 600 source : AC1 17) chain A residue 447 type sequence M description BINDING SITE FOR RESIDUE HEM A 600 source : AC1 18) chain A residue 115 type sequence R description BINDING SITE FOR RESIDUE ASD A 601 source : AC2 19) chain A residue 133 type sequence I description BINDING SITE FOR RESIDUE ASD A 601 source : AC2 20) chain A residue 224 type sequence W description BINDING SITE FOR RESIDUE ASD A 601 source : AC2 21) chain A residue 306 type sequence A description BINDING SITE FOR RESIDUE ASD A 601 source : AC2 22) chain A residue 309 type sequence D description BINDING SITE FOR RESIDUE ASD A 601 source : AC2 23) chain A residue 310 type sequence T description BINDING SITE FOR RESIDUE ASD A 601 source : AC2 24) chain A residue 370 type sequence V description BINDING SITE FOR RESIDUE ASD A 601 source : AC2 25) chain A residue 372 type sequence L description BINDING SITE FOR RESIDUE ASD A 601 source : AC2 26) chain A residue 374 type sequence M description BINDING SITE FOR RESIDUE ASD A 601 source : AC2 27) chain A residue 477 type sequence L description BINDING SITE FOR RESIDUE ASD A 601 source : AC2 28) chain A residue 72 type sequence S description BINDING SITE FOR RESIDUE PO4 A 504 source : AC3 29) chain A residue 75 type sequence N description BINDING SITE FOR RESIDUE PO4 A 504 source : AC3 30) chain A residue 475 type sequence H description BINDING SITE FOR RESIDUE PO4 A 504 source : AC3 31) chain A residue 109 type sequence H description BINDING SITE FOR RESIDUE PO4 A 505 source : AC4 32) chain A residue 110 type sequence N description BINDING SITE FOR RESIDUE PO4 A 505 source : AC4 33) chain A residue 111 type sequence H description BINDING SITE FOR RESIDUE PO4 A 505 source : AC4 34) chain A residue 169 type sequence K description BINDING SITE FOR RESIDUE PO4 A 506 source : AC5 35) chain A residue 342 type sequence E description BINDING SITE FOR RESIDUE PO4 A 506 source : AC5 36) chain A residue 343 type sequence R description BINDING SITE FOR RESIDUE PO4 A 506 source : AC5 37) chain A residue 344 type sequence D description BINDING SITE FOR RESIDUE PO4 A 506 source : AC5 38) chain A residue 456 type sequence R description BINDING SITE FOR RESIDUE PO4 A 506 source : AC5 39) chain A residue 303-323 type TRANSMEM sequence MLIAAPDTMSVSLFFMLFLIA description Helical => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 40) chain A residue 374 type BINDING sequence M description source Swiss-Prot : SWS_FT_FI2 41) chain A residue 309 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 42) chain A residue 430-439 type prosite sequence FGFGPRGCAG description CYTOCHROME_P450 Cytochrome P450 cysteine heme-iron ligand signature. FGfGPRGCAG source prosite : PS00086 43) chain A residue 437 type BINDING sequence C description axial binding residue => ECO:0000269|PubMed:19129847, ECO:0007744|PDB:3EQM source Swiss-Prot : SWS_FT_FI3

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