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eF-site ID
|
3s3k-A |
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PDB Code
|
3s3k |
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Chain
|
A |
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click to enlarge
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Title
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Crystal structure of the catalytic domain of PTP10D from Drosophila melanogaster with a small molecular inhibitor para-NitroCatechol Sulphate |
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Classification
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HYDROLASE/HYDROLASE INHIBITOR |
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Compound
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Tyrosine-protein phosphatase 10D |
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Source
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Drosophila melanogaster (Fruit fly) (PTP10_DROME) |
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Sequence
|
A: |
SHMASRPILIKNFAEHYRLMSADSDFRFSEEFEELKHVGR
DQPCTFADLPCNRPKNRFTNILPYDHSRFKLQPVDDDEGS
DYINANYVPGHNSPREFIVTQGPLHSTRDDFWRMCWESNS
RAIVMLTRCFEKGREKCDQYWPNDTVPVFYGDIKVQILND
SHYADWVMTEFMLCRGSEQRILRHFHFTTWPDFGVPNPPQ
TLVRFVRAFRDRIGAEQRPIVVHCSAGVGRSGTFITLDRI
LQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCL
LAVLEGK
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Description
|
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Functional site
|
|
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1)
|
chain |
A |
| residue |
242 |
| type |
ACT_SITE |
| sequence |
C
|
| description |
Phosphocysteine intermediate => ECO:0000255|PROSITE-ProRule:PRU00160, ECO:0000255|PROSITE-ProRule:PRU10044
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
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2)
|
chain |
A |
| residue |
210 |
| type |
BINDING |
| sequence |
D
|
| description |
BINDING => ECO:0000250
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
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3)
|
chain |
A |
| residue |
242 |
| type |
BINDING |
| sequence |
C
|
| description |
BINDING => ECO:0000250
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
4)
|
chain |
A |
| residue |
286 |
| type |
BINDING |
| sequence |
Q
|
| description |
BINDING => ECO:0000250
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
5)
|
chain |
A |
| residue |
240-250 |
| type |
prosite |
| sequence |
VHCSAGVGRSG
|
| description |
TYR_PHOSPHATASE_1 Tyrosine specific protein phosphatases active site. VHCsaGvgRSG
|
| source |
prosite : PS00383
|
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