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eF-site ID
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3s2k-B |
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PDB Code
|
3s2k |
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Chain
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B |
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click to enlarge
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Title
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Structural basis of Wnt signaling inhibition by Dickkopf binding to LRP5/6. |
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Classification
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SIGNALING PROTEIN |
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Compound
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Low-density lipoprotein receptor-related protein 6 |
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Source
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(DKK1_HUMAN) |
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Sequence
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B: |
ADPEAFLLFSRRADIRRISLETNNNNVAIPLTGVKEASAL
DFDVTDNRIYWTDISLKTISRAFMNGSALEHVVEFGLDYP
EGMAVDWLGKNLYWADTGTNRIEVSKLDGQHRQVLVWKDL
DSPRALALDPAEGFMYWTEWGGKPKIDRAAMDGSERTTLV
PNVGRANGLTIDYAKRRLYWTDLDTNLIESSNMLGLNREV
IADDLPHPFGLTQYQDYIYWTDWSRRSIERANKTSGQNRT
IIQGHLDYVMDILVFHSSRQSGWNECASSNGHCSHLCLAV
PVGGFVCGCPAHYSLNADNRTCSAPTTFLLFSQKSAINRM
VIDEQQSPDIILPIHSLRNVRAIDYDPLDKQLYWIDSRQN
MIRKAQEDGSQGFTVVVSEIQPYDLSIDIYSRYIYWTCEA
TNVINVTRLDGRSVGVVLKGEQDRPRAIVVNPEKGYMYFT
NLQERSPKIERAALDGTEREVLFFSGLSKPIALALDSRLG
KLFWADSDLRRIESSDLSGANRIVLEDSNILQPVGLTVFE
NWLYWIDKQQQMIEKIDMTGREGRTKVQARIAQLSDIHAV
KELNLQEYRQHPCAQDNGGCSHICLVKGDGTTRCSCPMHL
VLLQDELSCGEP
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Description
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(1) |
Low-density lipoprotein receptor-related protein 6, Dickkopf-related protein 1
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Functional site
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|
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1)
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chain |
B |
| residue |
1039 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:21805521
|
| source |
Swiss-Prot : SWS_FT_FI1
|
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2)
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chain |
B |
| residue |
692 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:21805521
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
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3)
|
chain |
B |
| residue |
859 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:21805521
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
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4)
|
chain |
B |
| residue |
865 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:21805521
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
5)
|
chain |
B |
| residue |
926 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:21805521
|
| source |
Swiss-Prot : SWS_FT_FI1
|
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