|
|
eF-site ID
|
3s2k-A |
|
PDB Code
|
3s2k |
|
Chain
|
A |
|
click to enlarge
|
|
|
Title
|
Structural basis of Wnt signaling inhibition by Dickkopf binding to LRP5/6. |
|
Classification
|
SIGNALING PROTEIN |
|
Compound
|
Low-density lipoprotein receptor-related protein 6 |
|
Source
|
(DKK1_HUMAN) |
|
|
Sequence
|
A: |
PEAFLLFSRRADIRRISLETNNNNVAIPLTGVKEASALDF
DVTDNRIYWTDISLKTISRAFMNGSALEHVVEFGLDYPEG
MAVDWLGKNLYWADTGTNRIEVSKLDGQHRQVLVWKDLDS
PRALALDPAEGFMYWTEWGGKPKIDRAAMDGSERTTLVPN
VGRANGLTIDYAKRRLYWTDLDTNLIESSNMLGLNREVIA
DDLPHPFGLTQYQDYIYWTDWSRRSIERANKTSGQNRTII
QGHLDYVMDILVFHSSRQSGWNECASSNGHCSHLCLAVPV
GGFVCGCPAHYSLNADNRTCSAPTTFLLFSQKSAINRMVI
DEQQSPDIILPIHSLRNVRAIDYDPLDKQLYWIDSRQNMI
RKAQEDGSQGFTVVVSEIQPYDLSIDIYSRYIYWTCEATN
VINVTRLDGRSVGVVLKGEQDRPRAIVVNPEKGYMYFTNL
QERSPKIERAALDGTEREVLFFSGLSKPIALALDSRLGKL
FWADSDLRRIESSDLSGANRIVLEDSNILQPVGLTVFENW
LYWIDKQQQMIEKIDMTGREGRTKVQARIAQLSDIHAVKE
LNLQEYRQHPCAQDNGGCSHICLVKGDGTTRCSCPMHLVL
LQDELSCGEP
|
|
|
Description
|
(1) |
Low-density lipoprotein receptor-related protein 6, Dickkopf-related protein 1
|
|
Functional site
|
|
|
1)
|
chain |
A |
| residue |
859 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:21805521
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
2)
|
chain |
A |
| residue |
865 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:21805521
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
3)
|
chain |
A |
| residue |
926 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:21805521
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
4)
|
chain |
A |
| residue |
1039 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:21805521
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
|