eF-site ID 3rv2-AB PDB Code 3rv2 Chain A, B click to enlarge Title Crystal structure of S-adenosylmethionine synthetase from Mycobacterium marinum Classification TRANSFERASE Compound S-adenosylmethionine synthase Source Mycobacterium marinum (strain ATCC BAA-535 / M) (METK_MYCMM) Sequence A:  GRLFTSESVTEGHPDKICDAVSDSVLDALLAADPRSRVAV ETLVTTGQVHVVGEVTTTAKEAFADITNIVRERILDIGYD SSDKGFDGASCGVNIGIGAQSPGDQGLMFGYAINDTPELM PLPIALAHRLSRRLTEVRKNGVLPYLRPDGKTQVTIAYED RVPVRLDTVVISTQHADDIDLVKTLDPDIREQVLKTVLDD LAHDTLDASAVRVLVNPTGKFVLGGPMGDAGLTGRKIIVD TYGGWARHGGGAFSGKDPSKVDRSAAYAMRWVAKNVVAAG LAERVEVQVAYAIGKAAPVGLFVETFGSEAVDPVKIEKAI GEVFDLRPGAIIRDLNLLRPIYAPTAAYGHFGRTDVDLPW ERLDKVDDLKRAI B:  GRLFTSESVTEGHPDKICDAVSDSVLDALLAADPRSRVAV ETLVTTGQVHVVGEVTTTAKEAFADITNIVRERILDIGYD SSDKGFDGASCGVNIGIGAQSPGDQGLMFGYAINDTPELM PLPIALAHRLSRRLTEVRKNGVLPYLRPDGKTQVTIAYED RVPVRLDTVVISTQHADDIDLVKTLDPDIREQVLKTVLDD LAHDTLDASAVRVLVNPTGKFVLGGPMGDAGLTGRKIIVD TYGGWARHGGGAFSGKDPSKVDRSAAYAMRWVAKNVVAAG LAERVEVQVAYAIGKAAPVGLFVETFGSEAVDPVKIEKAI GEVFDLRPGAIIRDLNLLRPIYAPTAAYGHFGRTDVDLPW ERLDKVDDLKRAI Description Functional site 1) chain A residue 259 type sequence D description BINDING SITE FOR RESIDUE CA A 404 source : AC1 2) chain A residue 394 type sequence D description BINDING SITE FOR RESIDUE CA A 405 source : AC2 3) chain A residue 397 type sequence D description BINDING SITE FOR RESIDUE CA A 405 source : AC2 4) chain A residue 398 type sequence D description BINDING SITE FOR RESIDUE CA A 405 source : AC2 5) chain A residue 158 type sequence H description BINDING SITE FOR RESIDUE EDO A 406 source : AC3 6) chain A residue 162 type sequence R description BINDING SITE FOR RESIDUE EDO A 406 source : AC3 7) chain A residue 382 type sequence G description BINDING SITE FOR RESIDUE EDO A 406 source : AC3 8) chain A residue 383 type sequence R description BINDING SITE FOR RESIDUE EDO A 406 source : AC3 9) chain A residue 384 type sequence T description BINDING SITE FOR RESIDUE EDO A 406 source : AC3 10) chain A residue 385 type sequence D description BINDING SITE FOR RESIDUE EDO A 406 source : AC3 11) chain A residue 41 type sequence R description BINDING SITE FOR RESIDUE GOL A 407 source : AC4 12) chain A residue 43 type sequence A description BINDING SITE FOR RESIDUE GOL A 407 source : AC4 13) chain A residue 58 type sequence E description BINDING SITE FOR RESIDUE GOL A 407 source : AC4 14) chain A residue 59 type sequence V description BINDING SITE FOR RESIDUE GOL A 407 source : AC4 15) chain A residue 60 type sequence T description BINDING SITE FOR RESIDUE GOL A 407 source : AC4 16) chain A residue 290 type sequence K description BINDING SITE FOR RESIDUE GOL A 407 source : AC4 17) chain B residue 259 type sequence D description BINDING SITE FOR RESIDUE CA B 404 source : AC5 18) chain B residue 158 type sequence H description BINDING SITE FOR RESIDUE EDO B 405 source : AC6 19) chain B residue 162 type sequence R description BINDING SITE FOR RESIDUE EDO B 405 source : AC6 20) chain B residue 382 type sequence G description BINDING SITE FOR RESIDUE EDO B 405 source : AC6 21) chain B residue 383 type sequence R description BINDING SITE FOR RESIDUE EDO B 405 source : AC6 22) chain B residue 384 type sequence T description BINDING SITE FOR RESIDUE EDO B 405 source : AC6 23) chain B residue 385 type sequence D description BINDING SITE FOR RESIDUE EDO B 405 source : AC6 24) chain A residue 363 type sequence R description BINDING SITE FOR RESIDUE EDO B 406 source : AC7 25) chain A residue 364 type sequence D description BINDING SITE FOR RESIDUE EDO B 406 source : AC7 26) chain B residue 364 type sequence D description BINDING SITE FOR RESIDUE EDO B 406 source : AC7 27) chain B residue 394 type sequence D description BINDING SITE FOR RESIDUE EDO B 406 source : AC7 28) chain B residue 395 type sequence K description BINDING SITE FOR RESIDUE EDO B 406 source : AC7 29) chain A residue 364 type sequence D description BINDING SITE FOR RESIDUE EDO B 407 source : AC8 30) chain A residue 394 type sequence D description BINDING SITE FOR RESIDUE EDO B 407 source : AC8 31) chain A residue 395 type sequence K description BINDING SITE FOR RESIDUE EDO B 407 source : AC8 32) chain B residue 363 type sequence R description BINDING SITE FOR RESIDUE EDO B 407 source : AC8 33) chain B residue 364 type sequence D description BINDING SITE FOR RESIDUE EDO B 407 source : AC8 34) chain B residue 41 type sequence R description BINDING SITE FOR RESIDUE GOL B 408 source : AC9 35) chain B residue 42 type sequence V description BINDING SITE FOR RESIDUE GOL B 408 source : AC9 36) chain B residue 43 type sequence A description BINDING SITE FOR RESIDUE GOL B 408 source : AC9 37) chain B residue 58 type sequence E description BINDING SITE FOR RESIDUE GOL B 408 source : AC9 38) chain B residue 59 type sequence V description BINDING SITE FOR RESIDUE GOL B 408 source : AC9 39) chain B residue 60 type sequence T description BINDING SITE FOR RESIDUE GOL B 408 source : AC9 40) chain B residue 290 type sequence K description BINDING SITE FOR RESIDUE GOL B 408 source : AC9 41) chain A residue 279-287 type prosite sequence GGGAFSGKD description ADOMET_SYNTHASE_2 S-adenosylmethionine synthase signature 2. GGGAFSgKD source prosite : PS00377 42) chain A residue 17 type BINDING sequence H description in other chain => ECO:0000255|HAMAP-Rule:MF_00086 source Swiss-Prot : SWS_FT_FI1 43) chain B residue 104 type BINDING sequence Q description in other chain => ECO:0000255|HAMAP-Rule:MF_00086 source Swiss-Prot : SWS_FT_FI1 44) chain B residue 179 type BINDING sequence D description in other chain => ECO:0000255|HAMAP-Rule:MF_00086 source Swiss-Prot : SWS_FT_FI1 45) chain B residue 250 type BINDING sequence K description in other chain => ECO:0000255|HAMAP-Rule:MF_00086 source Swiss-Prot : SWS_FT_FI1 46) chain B residue 265 type BINDING sequence R description in other chain => ECO:0000255|HAMAP-Rule:MF_00086 source Swiss-Prot : SWS_FT_FI1 47) chain B residue 290 type BINDING sequence K description in other chain => ECO:0000255|HAMAP-Rule:MF_00086 source Swiss-Prot : SWS_FT_FI1 48) chain A residue 58 type BINDING sequence E description in other chain => ECO:0000255|HAMAP-Rule:MF_00086 source Swiss-Prot : SWS_FT_FI1 49) chain A residue 104 type BINDING sequence Q description in other chain => ECO:0000255|HAMAP-Rule:MF_00086 source Swiss-Prot : SWS_FT_FI1 50) chain A residue 179 type BINDING sequence D description in other chain => ECO:0000255|HAMAP-Rule:MF_00086 source Swiss-Prot : SWS_FT_FI1 51) chain A residue 250 type BINDING sequence K description in other chain => ECO:0000255|HAMAP-Rule:MF_00086 source Swiss-Prot : SWS_FT_FI1 52) chain A residue 265 type BINDING sequence R description in other chain => ECO:0000255|HAMAP-Rule:MF_00086 source Swiss-Prot : SWS_FT_FI1 53) chain A residue 290 type BINDING sequence K description in other chain => ECO:0000255|HAMAP-Rule:MF_00086 source Swiss-Prot : SWS_FT_FI1 54) chain B residue 17 type BINDING sequence H description in other chain => ECO:0000255|HAMAP-Rule:MF_00086 source Swiss-Prot : SWS_FT_FI1 55) chain B residue 58 type BINDING sequence E description in other chain => ECO:0000255|HAMAP-Rule:MF_00086 source Swiss-Prot : SWS_FT_FI1 56) chain A residue 19 type BINDING sequence D description BINDING => ECO:0000255|HAMAP-Rule:MF_00086 source Swiss-Prot : SWS_FT_FI2 57) chain B residue 286 type BINDING sequence K description BINDING => ECO:0000255|HAMAP-Rule:MF_00086 source Swiss-Prot : SWS_FT_FI2 58) chain A residue 45 type BINDING sequence E description BINDING => ECO:0000255|HAMAP-Rule:MF_00086 source Swiss-Prot : SWS_FT_FI2 59) chain A residue 259 type BINDING sequence D description BINDING => ECO:0000255|HAMAP-Rule:MF_00086 source Swiss-Prot : SWS_FT_FI2 60) chain A residue 282 type BINDING sequence A description BINDING => ECO:0000255|HAMAP-Rule:MF_00086 source Swiss-Prot : SWS_FT_FI2 61) chain A residue 286 type BINDING sequence K description BINDING => ECO:0000255|HAMAP-Rule:MF_00086 source Swiss-Prot : SWS_FT_FI2 62) chain B residue 19 type BINDING sequence D description BINDING => ECO:0000255|HAMAP-Rule:MF_00086 source Swiss-Prot : SWS_FT_FI2 63) chain B residue 45 type BINDING sequence E description BINDING => ECO:0000255|HAMAP-Rule:MF_00086 source Swiss-Prot : SWS_FT_FI2 64) chain B residue 259 type BINDING sequence D description BINDING => ECO:0000255|HAMAP-Rule:MF_00086 source Swiss-Prot : SWS_FT_FI2 65) chain B residue 282 type BINDING sequence A description BINDING => ECO:0000255|HAMAP-Rule:MF_00086 source Swiss-Prot : SWS_FT_FI2

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