eF-site ID 3rov-ABCDEFGHIJKL PDB Code 3rov Chain A, B, C, D, E, F, G, H, I, J, K, L click to enlarge Title Insulin's biosynthesis and activity have opposing structural requirements: a new factor in neonatal diabetes mellitus Classification HORMONE Compound Insulin Source Homo sapiens (Human) (INS_HUMAN) Sequence A:  GIVEQCCTSICSLYQLENYCN B:  FVNQHLCGSHLVEALYLVCXERXFFYTKPT C:  GIVEQCCTSICSLYQLENYCN D:  FVNQHLCGSHLVEALYLVCXERXFFYTKPT E:  GIVEQCCTSICSLYQLENYCN F:  FVNQHLCGSHLVEALYLVCXERXFFYTKPT G:  GIVEQCCTSICSLYQLENYCN H:  FVNQHLCGSHLVEALYLVCXERXFFYTKPT I:  GIVEQCCTSICSLYQLENYCN J:  FVNQHLCGSHLVEALYLVCXERXFFYTKPT K:  GIVEQCCTSICSLYQLENYCN L:  FVNQHLCGSHLVEALYLVCXERXFFYTKPT Description Functional site 1) chain A residue 6 type sequence C description BINDING SITE FOR RESIDUE IPH A 22 source : AC1 2) chain A residue 10 type sequence I description BINDING SITE FOR RESIDUE IPH A 22 source : AC1 3) chain A residue 11 type sequence C description BINDING SITE FOR RESIDUE IPH A 22 source : AC1 4) chain F residue 5 type sequence H description BINDING SITE FOR RESIDUE IPH A 22 source : AC1 5) chain B residue 10 type sequence H description BINDING SITE FOR RESIDUE ZN B 31 source : AC2 6) chain F residue 10 type sequence H description BINDING SITE FOR RESIDUE ZN B 31 source : AC2 7) chain J residue 10 type sequence H description BINDING SITE FOR RESIDUE ZN B 31 source : AC2 8) chain J residue 10 type sequence H description BINDING SITE FOR RESIDUE CL B 32 source : AC3 9) chain C residue 6 type sequence C description BINDING SITE FOR RESIDUE IPH C 22 source : AC4 10) chain C residue 10 type sequence I description BINDING SITE FOR RESIDUE IPH C 22 source : AC4 11) chain C residue 11 type sequence C description BINDING SITE FOR RESIDUE IPH C 22 source : AC4 12) chain D residue 11 type sequence L description BINDING SITE FOR RESIDUE IPH C 22 source : AC4 13) chain L residue 5 type sequence H description BINDING SITE FOR RESIDUE IPH C 22 source : AC4 14) chain D residue 10 type sequence H description BINDING SITE FOR RESIDUE ZN D 31 source : AC5 15) chain H residue 10 type sequence H description BINDING SITE FOR RESIDUE ZN D 31 source : AC5 16) chain L residue 10 type sequence H description BINDING SITE FOR RESIDUE ZN D 31 source : AC5 17) chain E residue 6 type sequence C description BINDING SITE FOR RESIDUE IPH E 22 source : AC6 18) chain E residue 10 type sequence I description BINDING SITE FOR RESIDUE IPH E 22 source : AC6 19) chain E residue 11 type sequence C description BINDING SITE FOR RESIDUE IPH E 22 source : AC6 20) chain F residue 10 type sequence H description BINDING SITE FOR RESIDUE IPH E 22 source : AC6 21) chain J residue 6 type sequence L description BINDING SITE FOR RESIDUE IPH E 22 source : AC6 22) chain G residue 6 type sequence C description BINDING SITE FOR RESIDUE IPH G 22 source : AC7 23) chain G residue 11 type sequence C description BINDING SITE FOR RESIDUE IPH G 22 source : AC7 24) chain G residue 16 type sequence L description BINDING SITE FOR RESIDUE IPH G 22 source : AC7 25) chain H residue 10 type sequence H description BINDING SITE FOR RESIDUE IPH G 22 source : AC7 26) chain H residue 14 type sequence A description BINDING SITE FOR RESIDUE IPH G 22 source : AC7 27) chain H residue 10 type sequence H description BINDING SITE FOR RESIDUE CL H 31 source : AC8 28) chain B residue 5 type sequence H description BINDING SITE FOR RESIDUE IPH I 22 source : AC9 29) chain I residue 6 type sequence C description BINDING SITE FOR RESIDUE IPH I 22 source : AC9 30) chain I residue 10 type sequence I description BINDING SITE FOR RESIDUE IPH I 22 source : AC9 31) chain I residue 11 type sequence C description BINDING SITE FOR RESIDUE IPH I 22 source : AC9 32) chain J residue 11 type sequence L description BINDING SITE FOR RESIDUE IPH I 22 source : AC9 33) chain H residue 5 type sequence H description BINDING SITE FOR RESIDUE IPH K 22 source : BC1 34) chain K residue 6 type sequence C description BINDING SITE FOR RESIDUE IPH K 22 source : BC1 35) chain K residue 10 type sequence I description BINDING SITE FOR RESIDUE IPH K 22 source : BC1 36) chain K residue 11 type sequence C description BINDING SITE FOR RESIDUE IPH K 22 source : BC1 37) chain L residue 11 type sequence L description BINDING SITE FOR RESIDUE IPH K 22 source : BC1 38) chain A residue 6-20 type prosite sequence CCTSICSLYQLENYC description INSULIN Insulin family signature. CCTSiCSlyqLenyC source prosite : PS00262

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