|
eF-site ID
|
3riy-D |
PDB Code
|
3riy |
Chain
|
D |
|
click to enlarge
|
|
Title
|
Sirt5 is an NAD-dependent protein lysine demalonylase and desuccinylase |
Classification
|
HYDROLASE |
Compound
|
NAD-dependent deacetylase sirtuin-5 |
Source
|
Homo sapiens (Human) (3RIY) |
|
Sequence
|
D: |
TARXSTGG
|
|
Description
|
|
Functional site
|
|
1)
|
chain |
D |
residue |
9 |
type |
|
sequence |
X
|
description |
BINDING SITE FOR RESIDUE NAD A 2001
|
source |
: AC2
|
|
2)
|
chain |
D |
residue |
6 |
type |
MOD_RES |
sequence |
T
|
description |
Phosphothreonine; by PKC => ECO:0000269|PubMed:20228790
|
source |
Swiss-Prot : SWS_FT_FI3
|
|
3)
|
chain |
D |
residue |
8 |
type |
MOD_RES |
sequence |
R
|
description |
Symmetric dimethylarginine; by PRMT5; alternate => ECO:0000250|UniProtKB:P68433
|
source |
Swiss-Prot : SWS_FT_FI4
|
|
4)
|
chain |
D |
residue |
9 |
type |
MOD_RES |
sequence |
X
|
description |
N6-methyllysine; alternate => ECO:0000269|PubMed:11242053, ECO:0000269|PubMed:16185088, ECO:0000269|PubMed:16267050, ECO:0000269|PubMed:16457588, ECO:0000269|PubMed:17194708
|
source |
Swiss-Prot : SWS_FT_FI5
|
|
5)
|
chain |
D |
residue |
10 |
type |
MOD_RES |
sequence |
S
|
description |
Phosphoserine; alternate; by AURKB, AURKC, RPS6KA3, RPS6KA4 and RPS6KA5 => ECO:0000269|PubMed:10464286, ECO:0000269|PubMed:11856369, ECO:0000269|PubMed:12560483, ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:16185088, ECO:0000269|PubMed:16457588
|
source |
Swiss-Prot : SWS_FT_FI6
|
|
6)
|
chain |
D |
residue |
11 |
type |
MOD_RES |
sequence |
T
|
description |
Phosphothreonine; by PKC and CHEK1 => ECO:0000269|PubMed:12560483, ECO:0000269|PubMed:18066052, ECO:0000269|PubMed:18243098, ECO:0000269|PubMed:22901803
|
source |
Swiss-Prot : SWS_FT_FI7
|
|
|
|