eF-site ID 3riy-B PDB Code 3riy Chain B click to enlarge Title Sirt5 is an NAD-dependent protein lysine demalonylase and desuccinylase Classification HYDROLASE Compound NAD-dependent deacetylase sirtuin-5 Source Homo sapiens (Human) (3RIY) Sequence B:  SFTARPSSSMADFRKFFAKAKHIVIISGAGVSAESGVPTF RGAGGYWRKWQAQDLATPLAFAHNPSRVWEFYHYRREVMG SKEPNAGHRAIAECETRLGKQGRRVVVITQNIDELHRKAG TKNLLEIHGSLFKTRCTSCGVVAENYKSPICPALSGKGAP EPGTQDASIPVEKLPRCEEAGCGGLLRPHVVWFGENLDPA ILEEVDRELAHCDLCLVVGTSSVVYPAAMFAPQVAARGVP VAEFNTETTPATNRFRFHFQGPCGTTLPEALA Description Functional site 1) chain B residue 166 type sequence C description BINDING SITE FOR RESIDUE ZN B 1002 source : AC3 2) chain B residue 169 type sequence C description BINDING SITE FOR RESIDUE ZN B 1002 source : AC3 3) chain B residue 207 type sequence C description BINDING SITE FOR RESIDUE ZN B 1002 source : AC3 4) chain B residue 212 type sequence C description BINDING SITE FOR RESIDUE ZN B 1002 source : AC3 5) chain B residue 59 type sequence A description BINDING SITE FOR RESIDUE NAD B 2002 source : AC4 6) chain B residue 60 type sequence G description BINDING SITE FOR RESIDUE NAD B 2002 source : AC4 7) chain B residue 64 type sequence E description BINDING SITE FOR RESIDUE NAD B 2002 source : AC4 8) chain B residue 67 type sequence V description BINDING SITE FOR RESIDUE NAD B 2002 source : AC4 9) chain B residue 68 type sequence P description BINDING SITE FOR RESIDUE NAD B 2002 source : AC4 10) chain B residue 69 type sequence T description BINDING SITE FOR RESIDUE NAD B 2002 source : AC4 11) chain B residue 70 type sequence F description BINDING SITE FOR RESIDUE NAD B 2002 source : AC4 12) chain B residue 71 type sequence R description BINDING SITE FOR RESIDUE NAD B 2002 source : AC4 13) chain B residue 140 type sequence Q description BINDING SITE FOR RESIDUE NAD B 2002 source : AC4 14) chain B residue 141 type sequence N description BINDING SITE FOR RESIDUE NAD B 2002 source : AC4 15) chain B residue 142 type sequence I description BINDING SITE FOR RESIDUE NAD B 2002 source : AC4 16) chain B residue 143 type sequence D description BINDING SITE FOR RESIDUE NAD B 2002 source : AC4 17) chain B residue 158 type sequence H description BINDING SITE FOR RESIDUE NAD B 2002 source : AC4 18) chain B residue 249 type sequence G description BINDING SITE FOR RESIDUE NAD B 2002 source : AC4 19) chain B residue 250 type sequence T description BINDING SITE FOR RESIDUE NAD B 2002 source : AC4 20) chain B residue 251 type sequence S description BINDING SITE FOR RESIDUE NAD B 2002 source : AC4 21) chain B residue 275 type sequence N description BINDING SITE FOR RESIDUE NAD B 2002 source : AC4 22) chain B residue 276 type sequence T description BINDING SITE FOR RESIDUE NAD B 2002 source : AC4 23) chain B residue 277 type sequence E description BINDING SITE FOR RESIDUE NAD B 2002 source : AC4 24) chain B residue 292 type sequence P description BINDING SITE FOR RESIDUE NAD B 2002 source : AC4 25) chain B residue 293 type sequence C description BINDING SITE FOR RESIDUE NAD B 2002 source : AC4 26) chain B residue 293 type MOD_RES sequence C description 5-glutamyl serotonin; alternate => ECO:0000269|PubMed:30867594 source Swiss-Prot : SWS_FT_FI2 27) chain B residue 58 type MOD_RES sequence G description 5-glutamyl serotonin; alternate => ECO:0000269|PubMed:30867594 source Swiss-Prot : SWS_FT_FI2 28) chain B residue 140 type MOD_RES sequence Q description 5-glutamyl serotonin; alternate => ECO:0000269|PubMed:30867594 source Swiss-Prot : SWS_FT_FI2 29) chain B residue 249 type MOD_RES sequence G description 5-glutamyl serotonin; alternate => ECO:0000269|PubMed:30867594 source Swiss-Prot : SWS_FT_FI2 30) chain B residue 275 type MOD_RES sequence N description 5-glutamyl serotonin; alternate => ECO:0000269|PubMed:30867594 source Swiss-Prot : SWS_FT_FI2 31) chain B residue 169 type MOD_RES sequence C description Phosphothreonine; by PKC => ECO:0000269|PubMed:20228790 source Swiss-Prot : SWS_FT_FI3 32) chain B residue 207 type MOD_RES sequence C description Phosphothreonine; by PKC => ECO:0000269|PubMed:20228790 source Swiss-Prot : SWS_FT_FI3 33) chain B residue 212 type MOD_RES sequence C description Phosphothreonine; by PKC => ECO:0000269|PubMed:20228790 source Swiss-Prot : SWS_FT_FI3 34) chain B residue 102 type MOD_RES sequence Y description Phosphothreonine; by PKC => ECO:0000269|PubMed:20228790 source Swiss-Prot : SWS_FT_FI3 35) chain B residue 105 type MOD_RES sequence R description Phosphothreonine; by PKC => ECO:0000269|PubMed:20228790 source Swiss-Prot : SWS_FT_FI3 36) chain B residue 166 type MOD_RES sequence C description Phosphothreonine; by PKC => ECO:0000269|PubMed:20228790 source Swiss-Prot : SWS_FT_FI3

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