eF-site ID 3rig-A
PDB Code 3rig
Chain A

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Title Sirt5 is an NAD-dependent protein lysine demalonylase and desuccinylase
Classification HYDROLASE
Compound NAD-dependent deacetylase sirtuin-5
Source Homo sapiens (Human) (3RIG)
Sequence A:  SFTARPSSSMADFRKFFAKAKHIVIISGAGVGGYWRKWQA
QDLATPLAFAHNPSRVWEFYHYRREVMGSKEPNAGHRAIA
ECETRLGKQGRRVVVITQNIDELHRKAGTKNLLEIHGSLF
KTRCTSCGVVAENYKSPICPALSGKGAPEPGTQDASIPVE
KLPRCEEAGCGGLLRPHVVWFGENLDPAILEEVDRELAHC
DLCLVVGTSSVVYPAAMFAPQVAARGVPVAEFNTETTPAT
NRFRFHFQGPCGTTLPEALA
Description


Functional site

1) chain A
residue 166
type
sequence C
description BINDING SITE FOR RESIDUE ZN A 1001
source : AC1

2) chain A
residue 169
type
sequence C
description BINDING SITE FOR RESIDUE ZN A 1001
source : AC1

3) chain A
residue 207
type
sequence C
description BINDING SITE FOR RESIDUE ZN A 1001
source : AC1

4) chain A
residue 212
type
sequence C
description BINDING SITE FOR RESIDUE ZN A 1001
source : AC1

5) chain A
residue 74
type
sequence G
description BINDING SITE FOR RESIDUE NHE A 2001
source : AC2

6) chain A
residue 101
type
sequence F
description BINDING SITE FOR RESIDUE NHE A 2001
source : AC2

7) chain A
residue 102
type
sequence Y
description BINDING SITE FOR RESIDUE NHE A 2001
source : AC2

8) chain A
residue 105
type
sequence R
description BINDING SITE FOR RESIDUE NHE A 2001
source : AC2

9) chain A
residue 142
type
sequence I
description BINDING SITE FOR RESIDUE NHE A 2001
source : AC2

10) chain A
residue 254
type
sequence V
description BINDING SITE FOR RESIDUE NHE A 2001
source : AC2

11) chain A
residue 249
type MOD_RES
sequence G
description 5-glutamyl serotonin; alternate => ECO:0000269|PubMed:30867594
source Swiss-Prot : SWS_FT_FI2

12) chain A
residue 275
type MOD_RES
sequence N
description 5-glutamyl serotonin; alternate => ECO:0000269|PubMed:30867594
source Swiss-Prot : SWS_FT_FI2

13) chain A
residue 293
type MOD_RES
sequence C
description 5-glutamyl serotonin; alternate => ECO:0000269|PubMed:30867594
source Swiss-Prot : SWS_FT_FI2

14) chain A
residue 166
type MOD_RES
sequence C
description Phosphothreonine; by PKC => ECO:0000269|PubMed:20228790
source Swiss-Prot : SWS_FT_FI3

15) chain A
residue 169
type MOD_RES
sequence C
description Phosphothreonine; by PKC => ECO:0000269|PubMed:20228790
source Swiss-Prot : SWS_FT_FI3

16) chain A
residue 207
type MOD_RES
sequence C
description Phosphothreonine; by PKC => ECO:0000269|PubMed:20228790
source Swiss-Prot : SWS_FT_FI3

17) chain A
residue 212
type MOD_RES
sequence C
description Phosphothreonine; by PKC => ECO:0000269|PubMed:20228790
source Swiss-Prot : SWS_FT_FI3


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