eF-site ID 3r8a-AB PDB Code 3r8a Chain A, B click to enlarge Title X-ray crystal structure of the nuclear hormone receptor PPAR-gamma in a complex with a compound with dual PPAR gamma agonism and Angiotensin II Type I receptor antagonism activity Classification NUCLEAR PROTEIN Compound Peroxisome proliferator-activated receptor gamma Source Homo sapiens (Human) (PPARG_HUMAN) Sequence A:  ESADLRALAKHLYDSYIKSFPLTKAKARAILTGKDKSPFV IYDMNSLMMGEDKISKEVAIRIFQGCQFRSVEAVQEITEY AKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGV LISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALEL DDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALEL QLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKT ETDMSLHPLLQ B:  GESADLRALAKHLYDSYIKSFPLTKAKARAILTGKKSPFV IYDMNSLMMEVAIRIFQGCQFRSVEAVQEITEYAKSIPGF VNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQG FMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAI FIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHP ESSQLFAKLLQKMTDLRQIVTEHVQLLQVHPLLQEIYKD Description Functional site 1) chain A residue 281 type sequence I description BINDING SITE FOR RESIDUE HIG A 1 source : AC1 2) chain A residue 284 type sequence G description BINDING SITE FOR RESIDUE HIG A 1 source : AC1 3) chain A residue 285 type sequence C description BINDING SITE FOR RESIDUE HIG A 1 source : AC1 4) chain A residue 288 type sequence R description BINDING SITE FOR RESIDUE HIG A 1 source : AC1 5) chain A residue 289 type sequence S description BINDING SITE FOR RESIDUE HIG A 1 source : AC1 6) chain A residue 326 type sequence I description BINDING SITE FOR RESIDUE HIG A 1 source : AC1 7) chain A residue 330 type sequence L description BINDING SITE FOR RESIDUE HIG A 1 source : AC1 8) chain A residue 333 type sequence L description BINDING SITE FOR RESIDUE HIG A 1 source : AC1 9) chain A residue 339 type sequence V description BINDING SITE FOR RESIDUE HIG A 1 source : AC1 10) chain A residue 340 type sequence L description BINDING SITE FOR RESIDUE HIG A 1 source : AC1 11) chain A residue 341 type sequence I description BINDING SITE FOR RESIDUE HIG A 1 source : AC1 12) chain A residue 342 type sequence S description BINDING SITE FOR RESIDUE HIG A 1 source : AC1 13) chain A residue 348 type sequence M description BINDING SITE FOR RESIDUE HIG A 1 source : AC1 14) chain A residue 364 type sequence M description BINDING SITE FOR RESIDUE HIG A 1 source : AC1 15) chain B residue 284 type sequence G description BINDING SITE FOR RESIDUE HIG B 1 source : AC2 16) chain B residue 285 type sequence C description BINDING SITE FOR RESIDUE HIG B 1 source : AC2 17) chain B residue 288 type sequence R description BINDING SITE FOR RESIDUE HIG B 1 source : AC2 18) chain B residue 289 type sequence S description BINDING SITE FOR RESIDUE HIG B 1 source : AC2 19) chain B residue 326 type sequence I description BINDING SITE FOR RESIDUE HIG B 1 source : AC2 20) chain B residue 340 type sequence L description BINDING SITE FOR RESIDUE HIG B 1 source : AC2 21) chain B residue 341 type sequence I description BINDING SITE FOR RESIDUE HIG B 1 source : AC2 22) chain B residue 342 type sequence S description BINDING SITE FOR RESIDUE HIG B 1 source : AC2 23) chain B residue 348 type sequence M description BINDING SITE FOR RESIDUE HIG B 1 source : AC2 24) chain B residue 364 type sequence M description BINDING SITE FOR RESIDUE HIG B 1 source : AC2 25) chain A residue 286 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG source Swiss-Prot : SWS_FT_FI1 26) chain A residue 323 type BINDING sequence H description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG source Swiss-Prot : SWS_FT_FI1 27) chain A residue 449 type BINDING sequence H description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG source Swiss-Prot : SWS_FT_FI1 28) chain B residue 286 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG source Swiss-Prot : SWS_FT_FI1 29) chain B residue 323 type BINDING sequence H description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG source Swiss-Prot : SWS_FT_FI1 30) chain B residue 449 type BINDING sequence H description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG source Swiss-Prot : SWS_FT_FI1 31) chain B residue 473 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG source Swiss-Prot : SWS_FT_FI1 32) chain A residue 224 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:36737649 source Swiss-Prot : SWS_FT_FI2 33) chain B residue 224 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:36737649 source Swiss-Prot : SWS_FT_FI2

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