eF-site ID 3r4u-AB PDB Code 3r4u Chain A, B click to enlarge Title Cell entry of botulinum neurotoxin type C is dependent upon interaction with two ganglioside molecules Classification HYDROLASE Compound Botulinum neurotoxin type C1 Source Clostridium botulinum (BXC1_CLOBO) Sequence A:  SMANINDSKILSLQNRKNTLVDTSGYNAEVSEEGDVQLNP IFPFDFKLGSSGEDRGKVIVTQNENIVYNSMYESFSISFW IRINKWVSNLPGYTIIDSVKNNSGWSIGIISNFLVFTLKQ NEDSEQSINFSYDISNNAPGYNKWFFVTVTNNMMGNMKIY INGKLIDTIKVKELTGINFSKTITFEINKIPDTSDNINMW IRDFYIFAKELDGKDINILFNSLQYTNVVKDYWGNDLRYN KEYYMVNIDYLNRYMYANSRQIVFNTRRNNNDFNEGYKII IKRIRGNTNDTRVRGGDILYFDMTINNKAYNLFMKNETMY ADNHSTEDIYAIGLREQTKDINDNIIFQIQPMNNTYYYAS QIFKSNFNGENISGICSIGTYRFRLGGDWYRHNYLVPTVK QGNYASLLESTSTHWGFVPVSE B:  SMANINDSKILSLQNRKNTLVDTSGYNAEVSEEGDVQLNP IFPFDFKLGSSGEDRGKVIVTQNENIVYNSMYESFSISFW IRINKWVSNLPGYTIIDSVKNNSGWSIGIISNFLVFTLKQ NEDSEQSINFSYDISNNAPGYNKWFFVTVTNNMMGNMKIY INGKLIDTIKVKELTGINFSKTITFEINKIPDTSDNINMW IRDFYIFAKELDGKDINILFNSLQYTNVVKDYWGNDLRYN KEYYMVNIDYLNRYMYANSRQIVFNTRRNNNDFNEGYKII IKRIRGNTNDTRVRGGDILYFDMTINNKAYNLFMKNETMY ADNHSTEDIYAIGLREQTKDINDNIIFQIQPMNNTYYYAS QIFKSNFNGENISGICSIGTYRFRLGGDWYRHNYLVPTVK QGNYASLLESTSTHWGFVPVSE Description Functional site 1) chain A residue 1119 type BINDING sequence Y description GBP2 binding site => ECO:0000305|PubMed:23027864 source Swiss-Prot : SWS_FT_FI1 2) chain A residue 1247 type BINDING sequence I description GBP2 binding site => ECO:0000305|PubMed:23027864 source Swiss-Prot : SWS_FT_FI1 3) chain A residue 1281 type BINDING sequence S description GBP2 binding site => ECO:0000305|PubMed:23027864 source Swiss-Prot : SWS_FT_FI1 4) chain B residue 1119 type BINDING sequence Y description GBP2 binding site => ECO:0000305|PubMed:23027864 source Swiss-Prot : SWS_FT_FI1 5) chain B residue 1247 type BINDING sequence I description GBP2 binding site => ECO:0000305|PubMed:23027864 source Swiss-Prot : SWS_FT_FI1 6) chain B residue 1281 type BINDING sequence S description GBP2 binding site => ECO:0000305|PubMed:23027864 source Swiss-Prot : SWS_FT_FI1 7) chain A residue 1126 type BINDING sequence A description Sia-1 binding site => ECO:0000305|PubMed:21542861, ECO:0007744|PDB:3R4S source Swiss-Prot : SWS_FT_FI2 8) chain A residue 1146 type BINDING sequence Y description Sia-1 binding site => ECO:0000305|PubMed:21542861, ECO:0007744|PDB:3R4S source Swiss-Prot : SWS_FT_FI2 9) chain B residue 1126 type BINDING sequence A description Sia-1 binding site => ECO:0000305|PubMed:21542861, ECO:0007744|PDB:3R4S source Swiss-Prot : SWS_FT_FI2 10) chain B residue 1146 type BINDING sequence Y description Sia-1 binding site => ECO:0000305|PubMed:21542861, ECO:0007744|PDB:3R4S source Swiss-Prot : SWS_FT_FI2

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