|
|
eF-site ID
|
3r4s-A |
|
PDB Code
|
3r4s |
|
Chain
|
A |
|
click to enlarge
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Title
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Cell entry of botulinum neurotoxin type C is dependent upon interaction with two ganglioside molecules |
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Classification
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HYDROLASE |
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Compound
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Botulinum neurotoxin type C1 |
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Source
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Clostridium botulinum (BXC1_CLOBO) |
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Sequence
|
A: |
SMANINDSKILSLQNRKNTLVDTSGYNAEVSEEGDVQLNP
IFPFDFKLGSSGEDRGKVIVTQNENIVYNSMYESFSISFW
IRINKWVSNLPGYTIIDSVKNNSGWSIGIISNFLVFTLKQ
NEDSEQSINFSYDISNNAPGYNKWFFVTVTNNMMGNMKIY
INGKLIDTIKVKELTGINFSKTITFEINKIPDTGDSDNIN
MWIRDFYIFAKELDGKDINILFNSLQYTNVVKDYWGNDLR
YNKEYYMVNIDYLNRYMYANSRQIVFNTRRNNNDFNEGYK
IIIKRIRGNTNDTRVRGGDILYFDMTINNKAYNLFMKNET
MYADNHSTEDIYAIGLREQTKDINDNIIFQIQPMNNTYYY
ASQIFKSNFNGENISGICSIGTYRFRLGGDWYRHNYLVPT
VKQGNYASLLESTSTHWGFVPVSE
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Description
|
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Functional site
|
|
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1)
|
chain |
A |
| residue |
1126 |
| type |
BINDING |
| sequence |
A
|
| description |
Sia-1 binding site => ECO:0000305|PubMed:21542861, ECO:0007744|PDB:3R4S
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
2)
|
chain |
A |
| residue |
1146 |
| type |
BINDING |
| sequence |
Y
|
| description |
Sia-1 binding site => ECO:0000305|PubMed:21542861, ECO:0007744|PDB:3R4S
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
3)
|
chain |
A |
| residue |
1119 |
| type |
BINDING |
| sequence |
Y
|
| description |
GBP2 binding site => ECO:0000305|PubMed:23027864
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
4)
|
chain |
A |
| residue |
1247 |
| type |
BINDING |
| sequence |
I
|
| description |
GBP2 binding site => ECO:0000305|PubMed:23027864
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
5)
|
chain |
A |
| residue |
1281 |
| type |
BINDING |
| sequence |
S
|
| description |
GBP2 binding site => ECO:0000305|PubMed:23027864
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
|