|
|
eF-site ID
|
3r2a-C |
|
PDB Code
|
3r2a |
|
Chain
|
C |
|
click to enlarge
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Title
|
Crystal structure of RXRalpha ligand-binding domain complexed with corepressor SMRT2 and antagonist rhein |
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Classification
|
TRANSCRIPTION |
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Compound
|
Retinoic acid receptor RXR-alpha |
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Source
|
Homo sapiens (Human) (NCOR2_HUMAN) |
|
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Sequence
|
C: |
EDMPVERILEAELAVEPICQAADKQLFTLVEWAKRIPHFS
ELPLDDQVILLRAGWNELLIASFSHRSIAVKDGILLATGL
HVHRNSAHSAGVGAIFDRVLTELVSKMRDMQMDKTELGCL
RAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCKHKYPE
QPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTF
LME
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Description
|
|
Functional site
|
|
|
1)
|
chain |
C |
| residue |
306 |
| type |
|
| sequence |
N
|
| description |
BINDING SITE FOR RESIDUE RHN C 2
|
| source |
: AC2
|
|
|
2)
|
chain |
C |
| residue |
309 |
| type |
|
| sequence |
L
|
| description |
BINDING SITE FOR RESIDUE RHN C 2
|
| source |
: AC2
|
|
|
3)
|
chain |
C |
| residue |
345 |
| type |
|
| sequence |
I
|
| description |
BINDING SITE FOR RESIDUE RHN C 2
|
| source |
: AC2
|
|
|
4)
|
chain |
C |
| residue |
432 |
| type |
|
| sequence |
C
|
| description |
BINDING SITE FOR RESIDUE RHN C 2
|
| source |
: AC2
|
|
|
5)
|
chain |
C |
| residue |
436 |
| type |
|
| sequence |
L
|
| description |
BINDING SITE FOR RESIDUE RHN C 2
|
| source |
: AC2
|
|
|
6)
|
chain |
C |
| residue |
316 |
| type |
BINDING |
| sequence |
R
|
| description |
BINDING => ECO:0000269|PubMed:16107141, ECO:0000269|PubMed:18800767, ECO:0000269|PubMed:19167885, ECO:0007744|PDB:2ACL, ECO:0007744|PDB:3FAL, ECO:0007744|PDB:3FC6
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
7)
|
chain |
C |
| residue |
327 |
| type |
BINDING |
| sequence |
A
|
| description |
BINDING => ECO:0000269|PubMed:16107141, ECO:0000269|PubMed:18800767, ECO:0000269|PubMed:19167885, ECO:0007744|PDB:2ACL, ECO:0007744|PDB:3FAL, ECO:0007744|PDB:3FC6
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
|