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eF-site ID
|
3r2a-B |
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PDB Code
|
3r2a |
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Chain
|
B |
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click to enlarge
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Title
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Crystal structure of RXRalpha ligand-binding domain complexed with corepressor SMRT2 and antagonist rhein |
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Classification
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TRANSCRIPTION |
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Compound
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Retinoic acid receptor RXR-alpha |
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Source
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Homo sapiens (Human) (NCOR2_HUMAN) |
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Sequence
|
B: |
NEDMPVERILEAELAVENDPVTNICQAADKQLFTLVEWAK
RIPHFSELPLDDQVILLRAGWNELLIASFSHRSIAVKDGI
LLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDMQMDK
TELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAYC
KHKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGD
TPIDTFLMEMLEAPHQM
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Description
|
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Functional site
|
|
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1)
|
chain |
B |
| residue |
447 |
| type |
|
| sequence |
I
|
| description |
BINDING SITE FOR RESIDUE RHN C 2
|
| source |
: AC2
|
|
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2)
|
chain |
B |
| residue |
316 |
| type |
BINDING |
| sequence |
R
|
| description |
BINDING => ECO:0000269|PubMed:16107141, ECO:0000269|PubMed:18800767, ECO:0000269|PubMed:19167885, ECO:0007744|PDB:2ACL, ECO:0007744|PDB:3FAL, ECO:0007744|PDB:3FC6
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| source |
Swiss-Prot : SWS_FT_FI1
|
|
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3)
|
chain |
B |
| residue |
327 |
| type |
BINDING |
| sequence |
A
|
| description |
BINDING => ECO:0000269|PubMed:16107141, ECO:0000269|PubMed:18800767, ECO:0000269|PubMed:19167885, ECO:0007744|PDB:2ACL, ECO:0007744|PDB:3FAL, ECO:0007744|PDB:3FC6
|
| source |
Swiss-Prot : SWS_FT_FI1
|
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