eF-site ID 3r2a-ABCDEF PDB Code 3r2a Chain A, B, C, D, E, F click to enlarge Title Crystal structure of RXRalpha ligand-binding domain complexed with corepressor SMRT2 and antagonist rhein Classification TRANSCRIPTION Compound Retinoic acid receptor RXR-alpha Source Homo sapiens (Human) (NCOR2_HUMAN) Sequence A:  ANEDMPVERILEAELAVEPKDPVTNICQAADKQLFTLVEW AKRIPHFSELPLDDQVILLRAGWNELLIASFSHRSIAVKD GILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDMQM DKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEA YCKHKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLI GDTPIDTFLME B:  NEDMPVERILEAELAVENDPVTNICQAADKQLFTLVEWAK RIPHFSELPLDDQVILLRAGWNELLIASFSHRSIAVKDGI LLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDMQMDK TELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAYC KHKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGD TPIDTFLMEMLEAPHQM C:  EDMPVERILEAELAVEPICQAADKQLFTLVEWAKRIPHFS ELPLDDQVILLRAGWNELLIASFSHRSIAVKDGILLATGL HVHRNSAHSAGVGAIFDRVLTELVSKMRDMQMDKTELGCL RAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCKHKYPE QPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTF LME D:  NEDMPVERILEAELAVEPKTEPVTNICQAADKQLFTLVEW AKRIPHFSELPLDDQVILLRAGWNELLIASFSHRSIAVKD GILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDMQM DKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEA YCKHKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLI GDTPIDTFLMEMLEAPHQM E:  NMGLEAI F:  TNMGLEAII Description Functional site 1) chain A residue 268 type sequence I description BINDING SITE FOR RESIDUE RHN A 1 source : AC1 2) chain A residue 306 type sequence N description BINDING SITE FOR RESIDUE RHN A 1 source : AC1 3) chain A residue 313 type sequence F description BINDING SITE FOR RESIDUE RHN A 1 source : AC1 4) chain A residue 324 type sequence I description BINDING SITE FOR RESIDUE RHN A 1 source : AC1 5) chain A residue 432 type sequence C description BINDING SITE FOR RESIDUE RHN A 1 source : AC1 6) chain A residue 436 type sequence L description BINDING SITE FOR RESIDUE RHN A 1 source : AC1 7) chain B residue 447 type sequence I description BINDING SITE FOR RESIDUE RHN C 2 source : AC2 8) chain C residue 306 type sequence N description BINDING SITE FOR RESIDUE RHN C 2 source : AC2 9) chain C residue 309 type sequence L description BINDING SITE FOR RESIDUE RHN C 2 source : AC2 10) chain C residue 345 type sequence I description BINDING SITE FOR RESIDUE RHN C 2 source : AC2 11) chain C residue 432 type sequence C description BINDING SITE FOR RESIDUE RHN C 2 source : AC2 12) chain C residue 436 type sequence L description BINDING SITE FOR RESIDUE RHN C 2 source : AC2 13) chain A residue 316 type BINDING sequence R description BINDING => ECO:0000269|PubMed:16107141, ECO:0000269|PubMed:18800767, ECO:0000269|PubMed:19167885, ECO:0007744|PDB:2ACL, ECO:0007744|PDB:3FAL, ECO:0007744|PDB:3FC6 source Swiss-Prot : SWS_FT_FI1 14) chain A residue 327 type BINDING sequence A description BINDING => ECO:0000269|PubMed:16107141, ECO:0000269|PubMed:18800767, ECO:0000269|PubMed:19167885, ECO:0007744|PDB:2ACL, ECO:0007744|PDB:3FAL, ECO:0007744|PDB:3FC6 source Swiss-Prot : SWS_FT_FI1 15) chain B residue 316 type BINDING sequence R description BINDING => ECO:0000269|PubMed:16107141, ECO:0000269|PubMed:18800767, ECO:0000269|PubMed:19167885, ECO:0007744|PDB:2ACL, ECO:0007744|PDB:3FAL, ECO:0007744|PDB:3FC6 source Swiss-Prot : SWS_FT_FI1 16) chain B residue 327 type BINDING sequence A description BINDING => ECO:0000269|PubMed:16107141, ECO:0000269|PubMed:18800767, ECO:0000269|PubMed:19167885, ECO:0007744|PDB:2ACL, ECO:0007744|PDB:3FAL, ECO:0007744|PDB:3FC6 source Swiss-Prot : SWS_FT_FI1 17) chain C residue 316 type BINDING sequence R description BINDING => ECO:0000269|PubMed:16107141, ECO:0000269|PubMed:18800767, ECO:0000269|PubMed:19167885, ECO:0007744|PDB:2ACL, ECO:0007744|PDB:3FAL, ECO:0007744|PDB:3FC6 source Swiss-Prot : SWS_FT_FI1 18) chain C residue 327 type BINDING sequence A description BINDING => ECO:0000269|PubMed:16107141, ECO:0000269|PubMed:18800767, ECO:0000269|PubMed:19167885, ECO:0007744|PDB:2ACL, ECO:0007744|PDB:3FAL, ECO:0007744|PDB:3FC6 source Swiss-Prot : SWS_FT_FI1 19) chain D residue 316 type BINDING sequence R description BINDING => ECO:0000269|PubMed:16107141, ECO:0000269|PubMed:18800767, ECO:0000269|PubMed:19167885, ECO:0007744|PDB:2ACL, ECO:0007744|PDB:3FAL, ECO:0007744|PDB:3FC6 source Swiss-Prot : SWS_FT_FI1 20) chain D residue 327 type BINDING sequence A description BINDING => ECO:0000269|PubMed:16107141, ECO:0000269|PubMed:18800767, ECO:0000269|PubMed:19167885, ECO:0007744|PDB:2ACL, ECO:0007744|PDB:3FAL, ECO:0007744|PDB:3FC6 source Swiss-Prot : SWS_FT_FI1

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