eF-site ID 3qzq-D PDB Code 3qzq Chain D click to enlarge Title Human enterovirus 71 3C protease mutant E71D in complex with rupintrivir Classification HYDROLASE/HYDROLASE INHIBITOR Compound 3C protein Source Enterovirus A71 (E7E815_9ENTO) Sequence D:  FALSLLRRNVRQVQTDQGHFTMLGVRDRLAVLPRHSQPGK TIWIEHKLVNVLDAVELVDEQGVNLDLTLITLDTNEKFRD ITKFIPENISTASDATLVINTEHMPSMFVPVGDVVQYGFL NLSGKPTHRTMMYNFPTKAGQCGGVVTSVGKIIGIHIGGN GRQGFCAGLKRSYFA Description Functional site 1) chain D residue 39 type sequence R description BINDING SITE FOR RESIDUE AG7 D 501 source : AC4 2) chain D residue 40 type sequence H description BINDING SITE FOR RESIDUE AG7 D 501 source : AC4 3) chain D residue 125 type sequence L description BINDING SITE FOR RESIDUE AG7 D 501 source : AC4 4) chain D residue 126 type sequence N description BINDING SITE FOR RESIDUE AG7 D 501 source : AC4 5) chain D residue 127 type sequence L description BINDING SITE FOR RESIDUE AG7 D 501 source : AC4 6) chain D residue 128 type sequence S description BINDING SITE FOR RESIDUE AG7 D 501 source : AC4 7) chain D residue 130 type sequence K description BINDING SITE FOR RESIDUE AG7 D 501 source : AC4 8) chain D residue 142 type sequence T description BINDING SITE FOR RESIDUE AG7 D 501 source : AC4 9) chain D residue 143 type sequence K description BINDING SITE FOR RESIDUE AG7 D 501 source : AC4 10) chain D residue 144 type sequence A description BINDING SITE FOR RESIDUE AG7 D 501 source : AC4 11) chain D residue 145 type sequence G description BINDING SITE FOR RESIDUE AG7 D 501 source : AC4 12) chain D residue 147 type sequence C description BINDING SITE FOR RESIDUE AG7 D 501 source : AC4 13) chain D residue 161 type sequence H description BINDING SITE FOR RESIDUE AG7 D 501 source : AC4 14) chain D residue 162 type sequence I description BINDING SITE FOR RESIDUE AG7 D 501 source : AC4 15) chain D residue 163 type sequence G description BINDING SITE FOR RESIDUE AG7 D 501 source : AC4 16) chain D residue 164 type sequence G description BINDING SITE FOR RESIDUE AG7 D 501 source : AC4 17) chain D residue 165 type sequence N description BINDING SITE FOR RESIDUE AG7 D 501 source : AC4 18) chain D residue 170 type sequence F description BINDING SITE FOR RESIDUE AG7 D 501 source : AC4

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