eF-site ID 3qx3-B PDB Code 3qx3 Chain B click to enlarge Title Human topoisomerase IIbeta in complex with DNA and etoposide Classification ISOMERASE/DNA/ISOMERASE INHIBITOR Compound DNA topoisomerase 2-beta Source Homo sapiens (Human) (3QX3) Sequence B:  SKIKGIPKLDDANDAGGKHSLECTLILTEGDSAKSLAVSG LGVIGRDRYGVFPLRGKILNVREASHKQIMENAEINNIIK IVGLQYKKSYDDAESLKTLRYGKIMIMTDQDQDGSHIKGL LINFIHHNWPSLLKHGFLEEFITPAKEAKEYFADMERHRI LFRYAGPEDDAAITLAFSKKKIDDRKEWLTNFMEDRRQRR LHGTKHLTYNDFINKELILFSNSDNERSIPSLVDGFKPGQ RKVLFTCFKRNDKREVKVAQLAGSVAEMSAYHHGEQALMM TIVNLAQNFVGSNNINLLQPIGQFGTRLHGGKDAASPRYI FTMLSTLARLLFPAVDDNLLKFLYDDNQRVEPEWYIPIIP MVLINGAEGIGTGWACKLPNYDAREIVNNVRRMLDGLDPH PMLPNYKNFKGTIQELGQNQYAVSGEIFVVDRNTVEITEL PVRTWTQVYKEQVLEPMLNGPALISDYKEYHTDTTVKFVV KMTEEKLAQAEAAGLHKVFKLQTTLTCNSMVLFDHMGCLK KYETVQDILKEFFDLRLSYYGLRKEWLVGMLGAESTKLNN QARFILEKIQGKITIENRSKKDLIQMLVQRGYESDPVKAW KEAQGPDFNYILNMSLWSLTKEKVEELIKQRDAKGREVND LKRKSPSDLWKEDLAAFVEELDKVESQERED Description Functional site 1) chain B residue 557 type sequence D description BINDING SITE FOR RESIDUE MG B 1 source : AC4 2) chain B residue 559 type sequence D description BINDING SITE FOR RESIDUE MG B 1 source : AC4 3) chain B residue 867 type sequence N description BINDING SITE FOR RESIDUE MG B 1222 source : AC5 4) chain B residue 478 type sequence G description BINDING SITE FOR RESIDUE EVP D 1 source : AC6 5) chain B residue 479 type sequence D description BINDING SITE FOR RESIDUE EVP D 1 source : AC6 6) chain B residue 503 type sequence R description BINDING SITE FOR RESIDUE EVP D 1 source : AC6 7) chain B residue 782 type sequence M description BINDING SITE FOR RESIDUE EVP D 1 source : AC6 8) chain B residue 821 type ACT_SITE sequence Y description O-(5'-phospho-DNA)-tyrosine intermediate => ECO:0000255|PROSITE-ProRule:PRU01384, ECO:0000269|PubMed:21778401 source Swiss-Prot : SWS_FT_FI1 9) chain B residue 477 type BINDING sequence E description BINDING => ECO:0000255|PROSITE-ProRule:PRU00995 source Swiss-Prot : SWS_FT_FI2 10) chain B residue 557 type BINDING sequence D description BINDING => ECO:0000255|PROSITE-ProRule:PRU00995, ECO:0000269|PubMed:21778401 source Swiss-Prot : SWS_FT_FI3 11) chain B residue 559 type BINDING sequence D description BINDING => ECO:0000255|PROSITE-ProRule:PRU00995, ECO:0000269|PubMed:21778401 source Swiss-Prot : SWS_FT_FI3 12) chain B residue 678 type SITE sequence K description Interaction with DNA source Swiss-Prot : SWS_FT_FI4 13) chain B residue 739 type SITE sequence K description Interaction with DNA source Swiss-Prot : SWS_FT_FI4 14) chain B residue 947 type SITE sequence W description Interaction with DNA source Swiss-Prot : SWS_FT_FI4 15) chain B residue 505 type SITE sequence K description Interaction with DNA source Swiss-Prot : SWS_FT_FI4 16) chain B residue 508 type SITE sequence N description Interaction with DNA source Swiss-Prot : SWS_FT_FI4 17) chain B residue 677 type SITE sequence R description Interaction with DNA source Swiss-Prot : SWS_FT_FI4 18) chain B residue 773 type SITE sequence Y description Interaction with DNA => ECO:0000255|PROSITE-ProRule:PRU00995 source Swiss-Prot : SWS_FT_FI5 19) chain B residue 820 type SITE sequence R description Transition state stabilizer source Swiss-Prot : SWS_FT_FI6 20) chain B residue 872 type SITE sequence I description Important for DNA bending; intercalates between base pairs of target DNA source Swiss-Prot : SWS_FT_FI7 21) chain B residue 641 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 source Swiss-Prot : SWS_FT_FI8 22) chain B residue 671 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 source Swiss-Prot : SWS_FT_FI8 23) chain B residue 707 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 source Swiss-Prot : SWS_FT_FI8 24) chain B residue 1087 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 source Swiss-Prot : SWS_FT_FI8 25) chain B residue 638 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:25772364, ECO:0007744|PubMed:28112733 source Swiss-Prot : SWS_FT_FI9

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