eF-site ID 3qup-A
PDB Code 3qup
Chain A

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Title Inhibitor bound structure of the kinase domain of the murine receptor tyrosine kinase TYRO3 (Sky)
Classification Transferase/transferase inhibitor
Compound Tyrosine-protein kinase receptor TYRO3
Source Mus musculus (Mouse) (TYRO3_MOUSE)
Sequence A:  EDVLIPFTLGRMLGKGEFGSVREAQLVKVAVKMLSSDIEE
FLREAACMKEFDHPHVAKLVGVSLRSIPMVILPFMKHGDL
HAFLLASRIPFNLPLQTLVRFMVDIACGMEYLSSRNFIHR
DLAARNCMLAEDMTVCVADFGLLPVKWLALESLADNLYTV
HSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRL
KQPPECMEEVYDLMYQCWSADPKQRPSFTCLRMELENILG
H
Description


Functional site

1) chain A
residue 519
type
sequence F
description BINDING SITE FOR RESIDUE LUN A 1
source : AC1

2) chain A
residue 593
type
sequence L
description BINDING SITE FOR RESIDUE LUN A 1
source : AC1

3) chain A
residue 594
type
sequence P
description BINDING SITE FOR RESIDUE LUN A 1
source : AC1

4) chain A
residue 595
type
sequence F
description BINDING SITE FOR RESIDUE LUN A 1
source : AC1

5) chain A
residue 596
type
sequence M
description BINDING SITE FOR RESIDUE LUN A 1
source : AC1

6) chain A
residue 597
type
sequence K
description BINDING SITE FOR RESIDUE LUN A 1
source : AC1

7) chain A
residue 649
type
sequence R
description BINDING SITE FOR RESIDUE LUN A 1
source : AC1

8) chain A
residue 652
type
sequence M
description BINDING SITE FOR RESIDUE LUN A 1
source : AC1

9) chain A
residue 663
type
sequence D
description BINDING SITE FOR RESIDUE LUN A 1
source : AC1

10) chain A
residue 514-540
type prosite
sequence LGKGEFGSVREAQLVKVAVK
description PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGKGEFGSVReAqlkqedgsfvk.......VAVK
source prosite : PS00107

11) chain A
residue 641-653
type prosite
sequence FIHRDLAARNCML
description PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. FIHrDLAARNCML
source prosite : PS00109

12) chain A
residue 645
type ACT_SITE
sequence D
description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028
source Swiss-Prot : SWS_FT_FI1

13) chain A
residue 514
type BINDING
sequence L
description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
source Swiss-Prot : SWS_FT_FI2

14) chain A
residue 540
type BINDING
sequence K
description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
source Swiss-Prot : SWS_FT_FI2


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