eF-site ID 3qrf-FGHIMN PDB Code 3qrf Chain F, G, H, I, M, N click to enlarge Title Structure of a domain-swapped FOXP3 dimer Classification DNA BINDING PROTEIN/DNA Compound Nuclear factor of activated T-cells, cytoplasmic 2 Source null (3QRF) Sequence F:  MRPPFTYATLIRWAILEAPEKQRTLNEIYHWFTRMFAFFR NHPATWKNAIRHNLSLHKCFVRVESEKGAVWTVDELEFRK KR G:  MRPPFTYATLIRWAILEAPEKQRTLNEIYHWFTRMFAFFR NHPATWKNAIRHNLSLHKCFVRVESEKGAVWTVDELEFRK KR H:  MRPPFTYATLIRWAILEAPEKQRTLNEIYHWFTRMFAFFR NHPATWKNAIRHNLSLHKCFVRVESEKGAVWTVDELEFRK KR I:  MRPPFTYATLIRWAILEAPEKQRTLNEIYHWFTRMFAFFR NHPATWKNAIRHNLSLHKCFVRVESEKGAVWTVDELEFRK KR M:  SSVPLEWPLSSQSGSYELRIEVQPKPHHRAHYETEGSRGA VKAPTGGHPVVQLHGYMENKPLGLQIFIGTADERILKPHA FYQVHRITGKTVTTTSYEKIVGNTKVLEIPLEPKNNMRAT IDCAGILKLRNADIELRKGETDIGRKNTRVRLVFRVHIPE SSGRIVSLQTASNPIECSQRSAHELPMVERQDTDSCLVYG GQQMILTGQNFTSESKVVFTEKTTDGQQIWEMEATVAAAA AAPNMLFVEIPEYRNKHIRTPVKVNFYVINGKRKRSQPQH FTYHPV N:  SSVPLEWPLSSQSGSYELRIEVQPKPHHRAHYETEGSRGA VKAPTGGHPVVQLHGYMENKPLGLQIFIGTADERILKPHA FYQVHRITGKTVTTTSYEKIVGNTKVLEIPLEPKNNMRAT IDCAGILKLRNADIELRKGETDIGRKNTRVRLVFRVHIPE SSGRIVSLQTASNPIECSQRSAHELPMVERQDTDSCLVYG GQQMILTGQNFTSESKVVFTEKTTDGQQIWEMEATVAAAA AAPNMLFVEIPEYRNKHIRTPVKVNFYVINGKRKRSQPQH FTYHPV Description Functional site 1) chain F residue 389 type sequence L description BINDING SITE FOR RESIDUE MG F 1 source : AC1 2) chain F residue 390 type sequence S description BINDING SITE FOR RESIDUE MG F 1 source : AC1 3) chain F residue 392 type sequence H description BINDING SITE FOR RESIDUE MG F 1 source : AC1 4) chain F residue 395 type sequence F description BINDING SITE FOR RESIDUE MG F 1 source : AC1 5) chain G residue 389 type sequence L description BINDING SITE FOR RESIDUE MG G 1 source : AC2 6) chain G residue 390 type sequence S description BINDING SITE FOR RESIDUE MG G 1 source : AC2 7) chain G residue 392 type sequence H description BINDING SITE FOR RESIDUE MG G 1 source : AC2 8) chain G residue 395 type sequence F description BINDING SITE FOR RESIDUE MG G 1 source : AC2 9) chain H residue 389 type sequence L description BINDING SITE FOR RESIDUE MG H 1 source : AC3 10) chain H residue 390 type sequence S description BINDING SITE FOR RESIDUE MG H 1 source : AC3 11) chain H residue 392 type sequence H description BINDING SITE FOR RESIDUE MG H 1 source : AC3 12) chain H residue 395 type sequence F description BINDING SITE FOR RESIDUE MG H 1 source : AC3 13) chain I residue 389 type sequence L description BINDING SITE FOR RESIDUE MG I 1 source : AC4 14) chain I residue 390 type sequence S description BINDING SITE FOR RESIDUE MG I 1 source : AC4 15) chain I residue 392 type sequence H description BINDING SITE FOR RESIDUE MG I 1 source : AC4 16) chain I residue 395 type sequence F description BINDING SITE FOR RESIDUE MG I 1 source : AC4 17) chain G residue 417 type SITE sequence R description Cleavage; by PCSK1 or PCSK2 => ECO:0000269|PubMed:19117830 source Swiss-Prot : SWS_FT_FI1 18) chain H residue 417 type SITE sequence R description Cleavage; by PCSK1 or PCSK2 => ECO:0000269|PubMed:19117830 source Swiss-Prot : SWS_FT_FI1 19) chain I residue 417 type SITE sequence R description Cleavage; by PCSK1 or PCSK2 => ECO:0000269|PubMed:19117830 source Swiss-Prot : SWS_FT_FI1 20) chain F residue 417 type SITE sequence R description Cleavage; by PCSK1 or PCSK2 => ECO:0000269|PubMed:19117830 source Swiss-Prot : SWS_FT_FI1 21) chain H residue 393 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:Q99JB6 source Swiss-Prot : SWS_FT_FI2 22) chain I residue 393 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:Q99JB6 source Swiss-Prot : SWS_FT_FI2 23) chain G residue 393 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:Q99JB6 source Swiss-Prot : SWS_FT_FI2 24) chain F residue 393 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:Q99JB6 source Swiss-Prot : SWS_FT_FI2 25) chain F residue 381-387 type prosite sequence WKNAIRH description FORK_HEAD_2 Fork head domain signature 2. WKNAIRH source prosite : PS00658

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