eF-site ID 3qi2-B PDB Code 3qi2 Chain B click to enlarge Title A Galpha P-loop mutation prevents transition to the activated state: G42R bound to RGS14 GoLoco Classification SIGNALING PROTEIN Compound Guanine nucleotide-binding protein G(i) subunit alpha-1 Source Homo sapiens (Human) (RGS14_HUMAN) Sequence B:  VKLLLLGARESGKSTIVKQMKIIHEAGYSEEECKQYKAVV YSNTIQSIIAIIRAMGRLKIDFGDSARADDARQLFVLAGA AEEGFMTAELAGVIKRLWKDSGVQACFNRSREYQLNDSAA YYLNDLDRIAQPNYIPTQQDVLRTRVKTTGIVETHFTFKD LHFKMFDVGGQRSERKKWIHCFEGVTAIIFCVALSDYDLV LAEDEEMNRMHESMKLFDSICNNKWFTDTSIILFLNKKDL FEEKIKKSPLTICYPEYAGSNTYEEAAAYIQCQFEDLNKR KDTEIYTHFTCATDTKNVQFVFDAVTDVIIKNNL Description Functional site 1) chain B residue 43 type sequence E description BINDING SITE FOR RESIDUE GDP B 356 source : AC4 2) chain B residue 44 type sequence S description BINDING SITE FOR RESIDUE GDP B 356 source : AC4 3) chain B residue 45 type sequence G description BINDING SITE FOR RESIDUE GDP B 356 source : AC4 4) chain B residue 46 type sequence K description BINDING SITE FOR RESIDUE GDP B 356 source : AC4 5) chain B residue 47 type sequence S description BINDING SITE FOR RESIDUE GDP B 356 source : AC4 6) chain B residue 48 type sequence T description BINDING SITE FOR RESIDUE GDP B 356 source : AC4 7) chain B residue 150 type sequence D description BINDING SITE FOR RESIDUE GDP B 356 source : AC4 8) chain B residue 151 type sequence S description BINDING SITE FOR RESIDUE GDP B 356 source : AC4 9) chain B residue 176 type sequence R description BINDING SITE FOR RESIDUE GDP B 356 source : AC4 10) chain B residue 178 type sequence R description BINDING SITE FOR RESIDUE GDP B 356 source : AC4 11) chain B residue 269 type sequence N description BINDING SITE FOR RESIDUE GDP B 356 source : AC4 12) chain B residue 270 type sequence K description BINDING SITE FOR RESIDUE GDP B 356 source : AC4 13) chain B residue 272 type sequence D description BINDING SITE FOR RESIDUE GDP B 356 source : AC4 14) chain B residue 273 type sequence L description BINDING SITE FOR RESIDUE GDP B 356 source : AC4 15) chain B residue 325 type sequence C description BINDING SITE FOR RESIDUE GDP B 356 source : AC4 16) chain B residue 326 type sequence A description BINDING SITE FOR RESIDUE GDP B 356 source : AC4 17) chain B residue 327 type sequence T description BINDING SITE FOR RESIDUE GDP B 356 source : AC4 18) chain B residue 93 type sequence I description BINDING SITE FOR RESIDUE SO4 B 1 source : AC5 19) chain B residue 94 type sequence D description BINDING SITE FOR RESIDUE SO4 B 1 source : AC5 20) chain B residue 134 type sequence S description BINDING SITE FOR RESIDUE SO4 B 1 source : AC5 21) chain B residue 135 type sequence G description BINDING SITE FOR RESIDUE SO4 B 1 source : AC5 22) chain B residue 204 type MOD_RES sequence Q description Deamidated glutamine; by Photorhabdus PAU_02230 => ECO:0000269|PubMed:24141704 source Swiss-Prot : SWS_FT_FI8 23) chain B residue 178 type MOD_RES sequence R description ADP-ribosylarginine; by cholera toxin => ECO:0000250 source Swiss-Prot : SWS_FT_FI7 24) chain B residue 326 type BINDING sequence A description BINDING => ECO:0007744|PDB:1Y3A, ECO:0007744|PDB:2G83, ECO:0007744|PDB:2GTP, ECO:0007744|PDB:2IK8, ECO:0007744|PDB:2OM2, ECO:0007744|PDB:3ONW, ECO:0007744|PDB:3QE0, ECO:0007744|PDB:3QI2, ECO:0007744|PDB:3UMR, ECO:0007744|PDB:3UMS, ECO:0007744|PDB:4G5Q source Swiss-Prot : SWS_FT_FI6 25) chain B residue 43 type BINDING sequence E description BINDING => ECO:0000269|PubMed:21115486, ECO:0007744|PDB:1KJY, ECO:0007744|PDB:1Y3A, ECO:0007744|PDB:2G83, ECO:0007744|PDB:2GTP, ECO:0007744|PDB:2IK8, ECO:0007744|PDB:2OM2, ECO:0007744|PDB:2XNS, ECO:0007744|PDB:3ONW, ECO:0007744|PDB:3QE0, ECO:0007744|PDB:3QI2, ECO:0007744|PDB:3UMR, ECO:0007744|PDB:3UMS, ECO:0007744|PDB:4G5Q source Swiss-Prot : SWS_FT_FI1 26) chain B residue 269 type BINDING sequence N description BINDING => ECO:0000269|PubMed:21115486, ECO:0007744|PDB:1KJY, ECO:0007744|PDB:1Y3A, ECO:0007744|PDB:2G83, ECO:0007744|PDB:2GTP, ECO:0007744|PDB:2IK8, ECO:0007744|PDB:2OM2, ECO:0007744|PDB:2XNS, ECO:0007744|PDB:3ONW, ECO:0007744|PDB:3QE0, ECO:0007744|PDB:3QI2, ECO:0007744|PDB:3UMR, ECO:0007744|PDB:3UMS, ECO:0007744|PDB:4G5Q source Swiss-Prot : SWS_FT_FI1 27) chain B residue 47 type BINDING sequence S description BINDING => ECO:0000269|PubMed:18434541, ECO:0000269|PubMed:22383884, ECO:0007744|PDB:3QE0 source Swiss-Prot : SWS_FT_FI2 28) chain B residue 181 type BINDING sequence T description BINDING => ECO:0000269|PubMed:18434541, ECO:0000269|PubMed:22383884, ECO:0007744|PDB:3QE0 source Swiss-Prot : SWS_FT_FI2 29) chain B residue 151 type BINDING sequence S description BINDING => ECO:0007744|PDB:1KJY, ECO:0007744|PDB:2OM2, ECO:0007744|PDB:2XNS, ECO:0007744|PDB:3ONW, ECO:0007744|PDB:3QE0, ECO:0007744|PDB:3QI2, ECO:0007744|PDB:4G5Q source Swiss-Prot : SWS_FT_FI3 30) chain B residue 175 type BINDING sequence L description BINDING => ECO:0007744|PDB:1KJY, ECO:0007744|PDB:1Y3A, ECO:0007744|PDB:2G83, ECO:0007744|PDB:2GTP, ECO:0007744|PDB:2IK8, ECO:0007744|PDB:2OM2, ECO:0007744|PDB:2XNS, ECO:0007744|PDB:3ONW, ECO:0007744|PDB:3QE0, ECO:0007744|PDB:3QI2, ECO:0007744|PDB:3UMR, ECO:0007744|PDB:3UMS, ECO:0007744|PDB:4G5Q source Swiss-Prot : SWS_FT_FI4 31) chain B residue 200 type BINDING sequence D description BINDING => ECO:0000269|PubMed:21115486 source Swiss-Prot : SWS_FT_FI5

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