eF-site ID 3qi2-ABCD
PDB Code 3qi2
Chain A, B, C, D

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Title A Galpha P-loop mutation prevents transition to the activated state: G42R bound to RGS14 GoLoco
Classification SIGNALING PROTEIN
Compound Guanine nucleotide-binding protein G(i) subunit alpha-1
Source Homo sapiens (Human) (RGS14_HUMAN)
Sequence A:  GAREVKLLLLGARESGKSTIVKQMKIIHEAGYSEEECKQY
KAVVYSNTIQSIIAIIRAMGRLKIDFGDSARADDARQLFV
LAGAAEEGFMTAELAGVIKRLWKDSGVQACFNRSREYQLN
DSAAYYLNDLDRIAQPNYIPTQQDVLRTRVKTTGIVETHF
TFKDLHFKMFDVGGQRSERKKWIHCFEGVTAIIFCVALSD
YDLVLAEDEEMNRMHESMKLFDSICNNKWFTDTSIILFLN
KKDLFEEKIKKSPLTICYPEYAGSNTYEEAAAYIQCQFED
LNKRKDTKEIYTHFTCATDTKNVQFVFDAVTDVIIKNN
B:  VKLLLLGARESGKSTIVKQMKIIHEAGYSEEECKQYKAVV
YSNTIQSIIAIIRAMGRLKIDFGDSARADDARQLFVLAGA
AEEGFMTAELAGVIKRLWKDSGVQACFNRSREYQLNDSAA
YYLNDLDRIAQPNYIPTQQDVLRTRVKTTGIVETHFTFKD
LHFKMFDVGGQRSERKKWIHCFEGVTAIIFCVALSDYDLV
LAEDEEMNRMHESMKLFDSICNNKWFTDTSIILFLNKKDL
FEEKIKKSPLTICYPEYAGSNTYEEAAAYIQCQFEDLNKR
KDTEIYTHFTCATDTKNVQFVFDAVTDVIIKNNL
C:  DIEGLVELLNRVQSSHDQRGLLRKEDLVLPEFL
D:  EGLVELLNRVQSDQRGLLRKEDLVLPEFLQ
Description


Functional site
1) chain A
residue 42
type
sequence R
description BINDING SITE FOR RESIDUE GDP A 355
source : AC1
2) chain A
residue 43
type
sequence E
description BINDING SITE FOR RESIDUE GDP A 355
source : AC1
3) chain A
residue 44
type
sequence S
description BINDING SITE FOR RESIDUE GDP A 355
source : AC1
4) chain A
residue 45
type
sequence G
description BINDING SITE FOR RESIDUE GDP A 355
source : AC1
5) chain A
residue 46
type
sequence K
description BINDING SITE FOR RESIDUE GDP A 355
source : AC1
6) chain A
residue 47
type
sequence S
description BINDING SITE FOR RESIDUE GDP A 355
source : AC1
7) chain A
residue 48
type
sequence T
description BINDING SITE FOR RESIDUE GDP A 355
source : AC1
8) chain A
residue 151
type
sequence S
description BINDING SITE FOR RESIDUE GDP A 355
source : AC1
9) chain A
residue 176
type
sequence R
description BINDING SITE FOR RESIDUE GDP A 355
source : AC1
10) chain A
residue 178
type
sequence R
description BINDING SITE FOR RESIDUE GDP A 355
source : AC1
11) chain A
residue 269
type
sequence N
description BINDING SITE FOR RESIDUE GDP A 355
source : AC1
12) chain A
residue 270
type
sequence K
description BINDING SITE FOR RESIDUE GDP A 355
source : AC1
13) chain A
residue 272
type
sequence D
description BINDING SITE FOR RESIDUE GDP A 355
source : AC1
14) chain A
residue 273
type
sequence L
description BINDING SITE FOR RESIDUE GDP A 355
source : AC1
15) chain A
residue 325
type
sequence C
description BINDING SITE FOR RESIDUE GDP A 355
source : AC1
16) chain A
residue 326
type
sequence A
description BINDING SITE FOR RESIDUE GDP A 355
source : AC1
17) chain A
residue 327
type
sequence T
description BINDING SITE FOR RESIDUE GDP A 355
source : AC1
18) chain C
residue 516
type
sequence R
description BINDING SITE FOR RESIDUE GDP A 355
source : AC1
19) chain A
residue 62
type
sequence S
description BINDING SITE FOR RESIDUE SO4 A 2
source : AC2
20) chain A
residue 63
type
sequence E
description BINDING SITE FOR RESIDUE SO4 A 2
source : AC2
21) chain A
residue 271
type
sequence K
description BINDING SITE FOR RESIDUE GOL A 3
source : AC3
22) chain A
residue 275
type
sequence E
description BINDING SITE FOR RESIDUE GOL A 3
source : AC3
23) chain A
residue 297
type
sequence E
description BINDING SITE FOR RESIDUE GOL A 3
source : AC3
24) chain A
residue 323
type
sequence F
description BINDING SITE FOR RESIDUE GOL A 3
source : AC3
25) chain B
residue 43
type
sequence E
description BINDING SITE FOR RESIDUE GDP B 356
source : AC4
26) chain B
residue 44
type
sequence S
description BINDING SITE FOR RESIDUE GDP B 356
source : AC4
27) chain B
residue 45
type
sequence G
description BINDING SITE FOR RESIDUE GDP B 356
source : AC4
28) chain B
residue 46
type
sequence K
description BINDING SITE FOR RESIDUE GDP B 356
source : AC4
29) chain B
residue 47
type
sequence S
description BINDING SITE FOR RESIDUE GDP B 356
source : AC4
30) chain B
residue 48
type
sequence T
description BINDING SITE FOR RESIDUE GDP B 356
source : AC4
31) chain B
residue 150
type
sequence D
description BINDING SITE FOR RESIDUE GDP B 356
source : AC4
32) chain B
residue 151
type
sequence S
description BINDING SITE FOR RESIDUE GDP B 356
source : AC4
33) chain B
residue 176
type
sequence R
description BINDING SITE FOR RESIDUE GDP B 356
source : AC4
34) chain B
residue 178
type
sequence R
description BINDING SITE FOR RESIDUE GDP B 356
source : AC4
35) chain B
residue 269
type
sequence N
description BINDING SITE FOR RESIDUE GDP B 356
source : AC4
36) chain B
residue 270
type
sequence K
description BINDING SITE FOR RESIDUE GDP B 356
source : AC4
37) chain B
residue 272
type
sequence D
description BINDING SITE FOR RESIDUE GDP B 356
source : AC4
38) chain B
residue 273
type
sequence L
description BINDING SITE FOR RESIDUE GDP B 356
source : AC4
39) chain B
residue 325
type
sequence C
description BINDING SITE FOR RESIDUE GDP B 356
source : AC4
40) chain B
residue 326
type
sequence A
description BINDING SITE FOR RESIDUE GDP B 356
source : AC4
41) chain B
residue 327
type
sequence T
description BINDING SITE FOR RESIDUE GDP B 356
source : AC4
42) chain D
residue 516
type
sequence R
description BINDING SITE FOR RESIDUE GDP B 356
source : AC4
43) chain B
residue 93
type
sequence I
description BINDING SITE FOR RESIDUE SO4 B 1
source : AC5
44) chain B
residue 94
type
sequence D
description BINDING SITE FOR RESIDUE SO4 B 1
source : AC5
45) chain B
residue 134
type
sequence S
description BINDING SITE FOR RESIDUE SO4 B 1
source : AC5
46) chain B
residue 135
type
sequence G
description BINDING SITE FOR RESIDUE SO4 B 1
source : AC5
47) chain A
residue 204
type MOD_RES
sequence Q
description Deamidated glutamine; by Photorhabdus PAU_02230 => ECO:0000269|PubMed:24141704
source Swiss-Prot : SWS_FT_FI8
48) chain B
residue 204
type MOD_RES
sequence Q
description Deamidated glutamine; by Photorhabdus PAU_02230 => ECO:0000269|PubMed:24141704
source Swiss-Prot : SWS_FT_FI8
49) chain A
residue 178
type MOD_RES
sequence R
description ADP-ribosylarginine; by cholera toxin => ECO:0000250
source Swiss-Prot : SWS_FT_FI7
50) chain B
residue 178
type MOD_RES
sequence R
description ADP-ribosylarginine; by cholera toxin => ECO:0000250
source Swiss-Prot : SWS_FT_FI7
51) chain A
residue 326
type BINDING
sequence A
description BINDING => ECO:0007744|PDB:1Y3A, ECO:0007744|PDB:2G83, ECO:0007744|PDB:2GTP, ECO:0007744|PDB:2IK8, ECO:0007744|PDB:2OM2, ECO:0007744|PDB:3ONW, ECO:0007744|PDB:3QE0, ECO:0007744|PDB:3QI2, ECO:0007744|PDB:3UMR, ECO:0007744|PDB:3UMS, ECO:0007744|PDB:4G5Q
source Swiss-Prot : SWS_FT_FI6
52) chain B
residue 326
type BINDING
sequence A
description BINDING => ECO:0007744|PDB:1Y3A, ECO:0007744|PDB:2G83, ECO:0007744|PDB:2GTP, ECO:0007744|PDB:2IK8, ECO:0007744|PDB:2OM2, ECO:0007744|PDB:3ONW, ECO:0007744|PDB:3QE0, ECO:0007744|PDB:3QI2, ECO:0007744|PDB:3UMR, ECO:0007744|PDB:3UMS, ECO:0007744|PDB:4G5Q
source Swiss-Prot : SWS_FT_FI6
53) chain A
residue 43
type BINDING
sequence E
description BINDING => ECO:0000269|PubMed:21115486, ECO:0007744|PDB:1KJY, ECO:0007744|PDB:1Y3A, ECO:0007744|PDB:2G83, ECO:0007744|PDB:2GTP, ECO:0007744|PDB:2IK8, ECO:0007744|PDB:2OM2, ECO:0007744|PDB:2XNS, ECO:0007744|PDB:3ONW, ECO:0007744|PDB:3QE0, ECO:0007744|PDB:3QI2, ECO:0007744|PDB:3UMR, ECO:0007744|PDB:3UMS, ECO:0007744|PDB:4G5Q
source Swiss-Prot : SWS_FT_FI1
54) chain A
residue 269
type BINDING
sequence N
description BINDING => ECO:0000269|PubMed:21115486, ECO:0007744|PDB:1KJY, ECO:0007744|PDB:1Y3A, ECO:0007744|PDB:2G83, ECO:0007744|PDB:2GTP, ECO:0007744|PDB:2IK8, ECO:0007744|PDB:2OM2, ECO:0007744|PDB:2XNS, ECO:0007744|PDB:3ONW, ECO:0007744|PDB:3QE0, ECO:0007744|PDB:3QI2, ECO:0007744|PDB:3UMR, ECO:0007744|PDB:3UMS, ECO:0007744|PDB:4G5Q
source Swiss-Prot : SWS_FT_FI1
55) chain B
residue 43
type BINDING
sequence E
description BINDING => ECO:0000269|PubMed:21115486, ECO:0007744|PDB:1KJY, ECO:0007744|PDB:1Y3A, ECO:0007744|PDB:2G83, ECO:0007744|PDB:2GTP, ECO:0007744|PDB:2IK8, ECO:0007744|PDB:2OM2, ECO:0007744|PDB:2XNS, ECO:0007744|PDB:3ONW, ECO:0007744|PDB:3QE0, ECO:0007744|PDB:3QI2, ECO:0007744|PDB:3UMR, ECO:0007744|PDB:3UMS, ECO:0007744|PDB:4G5Q
source Swiss-Prot : SWS_FT_FI1
56) chain B
residue 269
type BINDING
sequence N
description BINDING => ECO:0000269|PubMed:21115486, ECO:0007744|PDB:1KJY, ECO:0007744|PDB:1Y3A, ECO:0007744|PDB:2G83, ECO:0007744|PDB:2GTP, ECO:0007744|PDB:2IK8, ECO:0007744|PDB:2OM2, ECO:0007744|PDB:2XNS, ECO:0007744|PDB:3ONW, ECO:0007744|PDB:3QE0, ECO:0007744|PDB:3QI2, ECO:0007744|PDB:3UMR, ECO:0007744|PDB:3UMS, ECO:0007744|PDB:4G5Q
source Swiss-Prot : SWS_FT_FI1
57) chain A
residue 47
type BINDING
sequence S
description BINDING => ECO:0000269|PubMed:18434541, ECO:0000269|PubMed:22383884, ECO:0007744|PDB:3QE0
source Swiss-Prot : SWS_FT_FI2
58) chain A
residue 181
type BINDING
sequence T
description BINDING => ECO:0000269|PubMed:18434541, ECO:0000269|PubMed:22383884, ECO:0007744|PDB:3QE0
source Swiss-Prot : SWS_FT_FI2
59) chain B
residue 47
type BINDING
sequence S
description BINDING => ECO:0000269|PubMed:18434541, ECO:0000269|PubMed:22383884, ECO:0007744|PDB:3QE0
source Swiss-Prot : SWS_FT_FI2
60) chain B
residue 181
type BINDING
sequence T
description BINDING => ECO:0000269|PubMed:18434541, ECO:0000269|PubMed:22383884, ECO:0007744|PDB:3QE0
source Swiss-Prot : SWS_FT_FI2
61) chain A
residue 151
type BINDING
sequence S
description BINDING => ECO:0007744|PDB:1KJY, ECO:0007744|PDB:2OM2, ECO:0007744|PDB:2XNS, ECO:0007744|PDB:3ONW, ECO:0007744|PDB:3QE0, ECO:0007744|PDB:3QI2, ECO:0007744|PDB:4G5Q
source Swiss-Prot : SWS_FT_FI3
62) chain B
residue 151
type BINDING
sequence S
description BINDING => ECO:0007744|PDB:1KJY, ECO:0007744|PDB:2OM2, ECO:0007744|PDB:2XNS, ECO:0007744|PDB:3ONW, ECO:0007744|PDB:3QE0, ECO:0007744|PDB:3QI2, ECO:0007744|PDB:4G5Q
source Swiss-Prot : SWS_FT_FI3
63) chain A
residue 175
type BINDING
sequence L
description BINDING => ECO:0007744|PDB:1KJY, ECO:0007744|PDB:1Y3A, ECO:0007744|PDB:2G83, ECO:0007744|PDB:2GTP, ECO:0007744|PDB:2IK8, ECO:0007744|PDB:2OM2, ECO:0007744|PDB:2XNS, ECO:0007744|PDB:3ONW, ECO:0007744|PDB:3QE0, ECO:0007744|PDB:3QI2, ECO:0007744|PDB:3UMR, ECO:0007744|PDB:3UMS, ECO:0007744|PDB:4G5Q
source Swiss-Prot : SWS_FT_FI4
64) chain B
residue 175
type BINDING
sequence L
description BINDING => ECO:0007744|PDB:1KJY, ECO:0007744|PDB:1Y3A, ECO:0007744|PDB:2G83, ECO:0007744|PDB:2GTP, ECO:0007744|PDB:2IK8, ECO:0007744|PDB:2OM2, ECO:0007744|PDB:2XNS, ECO:0007744|PDB:3ONW, ECO:0007744|PDB:3QE0, ECO:0007744|PDB:3QI2, ECO:0007744|PDB:3UMR, ECO:0007744|PDB:3UMS, ECO:0007744|PDB:4G5Q
source Swiss-Prot : SWS_FT_FI4
65) chain A
residue 200
type BINDING
sequence D
description BINDING => ECO:0000269|PubMed:21115486
source Swiss-Prot : SWS_FT_FI5
66) chain B
residue 200
type BINDING
sequence D
description BINDING => ECO:0000269|PubMed:21115486
source Swiss-Prot : SWS_FT_FI5

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