eF-site ID 3qe0-C
PDB Code 3qe0
Chain C

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Title A Galpha-i1 P-loop mutation prevents transition to the activated state
Classification SIGNALING PROTEIN
Compound Guanine nucleotide-binding protein G(i) subunit alpha-1
Source null (3QE0)
Sequence C:  VKLLLLGARESGKSTIVKQMKIIHEAGYSEEECKQYKAVV
YSNTIQSIIAIIRAMGRLKIDFGDSARADDARQLFVLAGG
FMTAELAGVIKRLWKDSGVQACFNRSREYQLNDSAAYYLN
DLDRIAQPNYIPTQQDVLRTRVKTTGIVETHFTFKDLHFK
MFDVGGQRSIHCFEGVTAIIFCVALSDYDLVMNRMHESMK
LFDSICNNKWFTDTSIILFLNKKDLFEEKIKKSPLTICYP
EYAGSNTYEEAAAYIQCQFEDLNKRKDTKEIYTHFTCATD
TKNVQFVFDAVTDVIIKNN
Description


Functional site
1) chain C
residue 47
type
sequence S
description BINDING SITE FOR RESIDUE MG C 552
source : AC5
2) chain C
residue 179
type
sequence V
description BINDING SITE FOR RESIDUE MG C 552
source : AC5
3) chain C
residue 181
type
sequence T
description BINDING SITE FOR RESIDUE MG C 552
source : AC5
4) chain C
residue 41
type
sequence A
description BINDING SITE FOR RESIDUE GDP C 551
source : AC6
5) chain C
residue 42
type
sequence R
description BINDING SITE FOR RESIDUE GDP C 551
source : AC6
6) chain C
residue 43
type
sequence E
description BINDING SITE FOR RESIDUE GDP C 551
source : AC6
7) chain C
residue 44
type
sequence S
description BINDING SITE FOR RESIDUE GDP C 551
source : AC6
8) chain C
residue 45
type
sequence G
description BINDING SITE FOR RESIDUE GDP C 551
source : AC6
9) chain C
residue 46
type
sequence K
description BINDING SITE FOR RESIDUE GDP C 551
source : AC6
10) chain C
residue 47
type
sequence S
description BINDING SITE FOR RESIDUE GDP C 551
source : AC6
11) chain C
residue 48
type
sequence T
description BINDING SITE FOR RESIDUE GDP C 551
source : AC6
12) chain C
residue 151
type
sequence S
description BINDING SITE FOR RESIDUE GDP C 551
source : AC6
13) chain C
residue 175
type
sequence L
description BINDING SITE FOR RESIDUE GDP C 551
source : AC6
14) chain C
residue 176
type
sequence R
description BINDING SITE FOR RESIDUE GDP C 551
source : AC6
15) chain C
residue 177
type
sequence T
description BINDING SITE FOR RESIDUE GDP C 551
source : AC6
16) chain C
residue 178
type
sequence R
description BINDING SITE FOR RESIDUE GDP C 551
source : AC6
17) chain C
residue 269
type
sequence N
description BINDING SITE FOR RESIDUE GDP C 551
source : AC6
18) chain C
residue 270
type
sequence K
description BINDING SITE FOR RESIDUE GDP C 551
source : AC6
19) chain C
residue 272
type
sequence D
description BINDING SITE FOR RESIDUE GDP C 551
source : AC6
20) chain C
residue 273
type
sequence L
description BINDING SITE FOR RESIDUE GDP C 551
source : AC6
21) chain C
residue 325
type
sequence C
description BINDING SITE FOR RESIDUE GDP C 551
source : AC6
22) chain C
residue 326
type
sequence A
description BINDING SITE FOR RESIDUE GDP C 551
source : AC6
23) chain C
residue 327
type
sequence T
description BINDING SITE FOR RESIDUE GDP C 551
source : AC6
24) chain C
residue 175
type BINDING
sequence L
description BINDING => ECO:0007744|PDB:1KJY, ECO:0007744|PDB:1Y3A, ECO:0007744|PDB:2G83, ECO:0007744|PDB:2GTP, ECO:0007744|PDB:2IK8, ECO:0007744|PDB:2OM2, ECO:0007744|PDB:2XNS, ECO:0007744|PDB:3ONW, ECO:0007744|PDB:3QE0, ECO:0007744|PDB:3QI2, ECO:0007744|PDB:3UMR, ECO:0007744|PDB:3UMS, ECO:0007744|PDB:4G5Q
source Swiss-Prot : SWS_FT_FI4
25) chain C
residue 326
type BINDING
sequence A
description BINDING => ECO:0007744|PDB:1Y3A, ECO:0007744|PDB:2G83, ECO:0007744|PDB:2GTP, ECO:0007744|PDB:2IK8, ECO:0007744|PDB:2OM2, ECO:0007744|PDB:3ONW, ECO:0007744|PDB:3QE0, ECO:0007744|PDB:3QI2, ECO:0007744|PDB:3UMR, ECO:0007744|PDB:3UMS, ECO:0007744|PDB:4G5Q
source Swiss-Prot : SWS_FT_FI6
26) chain C
residue 200
type BINDING
sequence D
description BINDING => ECO:0000269|PubMed:21115486
source Swiss-Prot : SWS_FT_FI5
27) chain C
residue 43
type BINDING
sequence E
description BINDING => ECO:0000269|PubMed:21115486, ECO:0007744|PDB:1KJY, ECO:0007744|PDB:1Y3A, ECO:0007744|PDB:2G83, ECO:0007744|PDB:2GTP, ECO:0007744|PDB:2IK8, ECO:0007744|PDB:2OM2, ECO:0007744|PDB:2XNS, ECO:0007744|PDB:3ONW, ECO:0007744|PDB:3QE0, ECO:0007744|PDB:3QI2, ECO:0007744|PDB:3UMR, ECO:0007744|PDB:3UMS, ECO:0007744|PDB:4G5Q
source Swiss-Prot : SWS_FT_FI1
28) chain C
residue 269
type BINDING
sequence N
description BINDING => ECO:0000269|PubMed:21115486, ECO:0007744|PDB:1KJY, ECO:0007744|PDB:1Y3A, ECO:0007744|PDB:2G83, ECO:0007744|PDB:2GTP, ECO:0007744|PDB:2IK8, ECO:0007744|PDB:2OM2, ECO:0007744|PDB:2XNS, ECO:0007744|PDB:3ONW, ECO:0007744|PDB:3QE0, ECO:0007744|PDB:3QI2, ECO:0007744|PDB:3UMR, ECO:0007744|PDB:3UMS, ECO:0007744|PDB:4G5Q
source Swiss-Prot : SWS_FT_FI1
29) chain C
residue 47
type BINDING
sequence S
description BINDING => ECO:0000269|PubMed:18434541, ECO:0000269|PubMed:22383884, ECO:0007744|PDB:3QE0
source Swiss-Prot : SWS_FT_FI2
30) chain C
residue 181
type BINDING
sequence T
description BINDING => ECO:0000269|PubMed:18434541, ECO:0000269|PubMed:22383884, ECO:0007744|PDB:3QE0
source Swiss-Prot : SWS_FT_FI2
31) chain C
residue 151
type BINDING
sequence S
description BINDING => ECO:0007744|PDB:1KJY, ECO:0007744|PDB:2OM2, ECO:0007744|PDB:2XNS, ECO:0007744|PDB:3ONW, ECO:0007744|PDB:3QE0, ECO:0007744|PDB:3QI2, ECO:0007744|PDB:4G5Q
source Swiss-Prot : SWS_FT_FI3
32) chain C
residue 178
type MOD_RES
sequence R
description ADP-ribosylarginine; by cholera toxin => ECO:0000250
source Swiss-Prot : SWS_FT_FI7
33) chain C
residue 204
type MOD_RES
sequence Q
description Deamidated glutamine; by Photorhabdus PAU_02230 => ECO:0000269|PubMed:24141704
source Swiss-Prot : SWS_FT_FI8

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