eF-site ID 3qe0-ABCFG
PDB Code 3qe0
Chain A, B, C, F, G

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Title A Galpha-i1 P-loop mutation prevents transition to the activated state
Classification SIGNALING PROTEIN
Compound Guanine nucleotide-binding protein G(i) subunit alpha-1
Source Homo sapiens (Human) (3QE0)
Sequence A:  AEVKLLLLGARESGKSTIVKQMKIIHEAGYSEEECKQYKA
VVYSNTIQSIIAIIRAMGRLKIDFGDSARADDARQLFVLA
GAFMTAELAGVIKRLWKDSGVQACFNRSREYQLNDSAAYY
LNDLDRIAQPNYIPTQQDVLRTRVKTTGIVETHFTFKDLH
FKMFDVGSERKKWIHCFEGVTAIIFCVALSDYDLVLAEEM
NRMHESMKLFDSICNNKWFTDTSIILFLNKKDLFEEKIKK
SPLTICYPEYAGSNTYEEAAAYIQCQFEDLNKRKDTKEIY
THFTCATDTKNVQFVFDAVTDVIIKNNLKDCGLF
B:  AEVKLLLLGARESGKSTIVKQMKIIHEAGYSEEECKQYKA
VVYSNTIQSIIAIIRAMGRLKIDFGDSARADDARQLFVLA
AEEGFMTAELAGVIKRLWKDSGVQACFNRSREYQLNDSAA
YYLNDLDRIAQPNYIPTQQDVLRTRVKTTGIVETHFTFKD
LHFKMFDVGGQRSERKKWIHCFEGVTAIIFCVALSDYDLV
LAEDEEMNRMHESMKLFDSICNNKWFTDTSIILFLNKKDL
FEEKIKKSPLTICYPEYAGSNTYEEAAAYIQCQFEDLNKR
KDTKEIYTHFTCATDTKNVQFVFDAVTDVIIKNN
C:  VKLLLLGARESGKSTIVKQMKIIHEAGYSEEECKQYKAVV
YSNTIQSIIAIIRAMGRLKIDFGDSARADDARQLFVLAGG
FMTAELAGVIKRLWKDSGVQACFNRSREYQLNDSAAYYLN
DLDRIAQPNYIPTQQDVLRTRVKTTGIVETHFTFKDLHFK
MFDVGGQRSIHCFEGVTAIIFCVALSDYDLVMNRMHESMK
LFDSICNNKWFTDTSIILFLNKKDLFEEKIKKSPLTICYP
EYAGSNTYEEAAAYIQCQFEDLNKRKDTKEIYTHFTCATD
TKNVQFVFDAVTDVIIKNN
F:  TWYDFL
G:  SRVTWYDFLME
Description


Functional site
1) chain A
residue 47
type
sequence S
description BINDING SITE FOR RESIDUE MG A 556
source : AC1
2) chain A
residue 181
type
sequence T
description BINDING SITE FOR RESIDUE MG A 556
source : AC1
3) chain A
residue 42
type
sequence R
description BINDING SITE FOR RESIDUE GDP A 555
source : AC2
4) chain A
residue 43
type
sequence E
description BINDING SITE FOR RESIDUE GDP A 555
source : AC2
5) chain A
residue 44
type
sequence S
description BINDING SITE FOR RESIDUE GDP A 555
source : AC2
6) chain A
residue 45
type
sequence G
description BINDING SITE FOR RESIDUE GDP A 555
source : AC2
7) chain A
residue 46
type
sequence K
description BINDING SITE FOR RESIDUE GDP A 555
source : AC2
8) chain A
residue 47
type
sequence S
description BINDING SITE FOR RESIDUE GDP A 555
source : AC2
9) chain A
residue 48
type
sequence T
description BINDING SITE FOR RESIDUE GDP A 555
source : AC2
10) chain A
residue 151
type
sequence S
description BINDING SITE FOR RESIDUE GDP A 555
source : AC2
11) chain A
residue 175
type
sequence L
description BINDING SITE FOR RESIDUE GDP A 555
source : AC2
12) chain A
residue 176
type
sequence R
description BINDING SITE FOR RESIDUE GDP A 555
source : AC2
13) chain A
residue 177
type
sequence T
description BINDING SITE FOR RESIDUE GDP A 555
source : AC2
14) chain A
residue 178
type
sequence R
description BINDING SITE FOR RESIDUE GDP A 555
source : AC2
15) chain A
residue 269
type
sequence N
description BINDING SITE FOR RESIDUE GDP A 555
source : AC2
16) chain A
residue 270
type
sequence K
description BINDING SITE FOR RESIDUE GDP A 555
source : AC2
17) chain A
residue 272
type
sequence D
description BINDING SITE FOR RESIDUE GDP A 555
source : AC2
18) chain A
residue 273
type
sequence L
description BINDING SITE FOR RESIDUE GDP A 555
source : AC2
19) chain A
residue 325
type
sequence C
description BINDING SITE FOR RESIDUE GDP A 555
source : AC2
20) chain A
residue 326
type
sequence A
description BINDING SITE FOR RESIDUE GDP A 555
source : AC2
21) chain A
residue 327
type
sequence T
description BINDING SITE FOR RESIDUE GDP A 555
source : AC2
22) chain B
residue 47
type
sequence S
description BINDING SITE FOR RESIDUE MG B 556
source : AC3
23) chain B
residue 43
type
sequence E
description BINDING SITE FOR RESIDUE GDP B 355
source : AC4
24) chain B
residue 44
type
sequence S
description BINDING SITE FOR RESIDUE GDP B 355
source : AC4
25) chain B
residue 45
type
sequence G
description BINDING SITE FOR RESIDUE GDP B 355
source : AC4
26) chain B
residue 46
type
sequence K
description BINDING SITE FOR RESIDUE GDP B 355
source : AC4
27) chain B
residue 47
type
sequence S
description BINDING SITE FOR RESIDUE GDP B 355
source : AC4
28) chain B
residue 48
type
sequence T
description BINDING SITE FOR RESIDUE GDP B 355
source : AC4
29) chain B
residue 151
type
sequence S
description BINDING SITE FOR RESIDUE GDP B 355
source : AC4
30) chain B
residue 175
type
sequence L
description BINDING SITE FOR RESIDUE GDP B 355
source : AC4
31) chain B
residue 176
type
sequence R
description BINDING SITE FOR RESIDUE GDP B 355
source : AC4
32) chain B
residue 177
type
sequence T
description BINDING SITE FOR RESIDUE GDP B 355
source : AC4
33) chain B
residue 178
type
sequence R
description BINDING SITE FOR RESIDUE GDP B 355
source : AC4
34) chain B
residue 269
type
sequence N
description BINDING SITE FOR RESIDUE GDP B 355
source : AC4
35) chain B
residue 270
type
sequence K
description BINDING SITE FOR RESIDUE GDP B 355
source : AC4
36) chain B
residue 272
type
sequence D
description BINDING SITE FOR RESIDUE GDP B 355
source : AC4
37) chain B
residue 273
type
sequence L
description BINDING SITE FOR RESIDUE GDP B 355
source : AC4
38) chain B
residue 325
type
sequence C
description BINDING SITE FOR RESIDUE GDP B 355
source : AC4
39) chain B
residue 326
type
sequence A
description BINDING SITE FOR RESIDUE GDP B 355
source : AC4
40) chain B
residue 327
type
sequence T
description BINDING SITE FOR RESIDUE GDP B 355
source : AC4
41) chain C
residue 47
type
sequence S
description BINDING SITE FOR RESIDUE MG C 552
source : AC5
42) chain C
residue 179
type
sequence V
description BINDING SITE FOR RESIDUE MG C 552
source : AC5
43) chain C
residue 181
type
sequence T
description BINDING SITE FOR RESIDUE MG C 552
source : AC5
44) chain C
residue 41
type
sequence A
description BINDING SITE FOR RESIDUE GDP C 551
source : AC6
45) chain C
residue 42
type
sequence R
description BINDING SITE FOR RESIDUE GDP C 551
source : AC6
46) chain C
residue 43
type
sequence E
description BINDING SITE FOR RESIDUE GDP C 551
source : AC6
47) chain C
residue 44
type
sequence S
description BINDING SITE FOR RESIDUE GDP C 551
source : AC6
48) chain C
residue 45
type
sequence G
description BINDING SITE FOR RESIDUE GDP C 551
source : AC6
49) chain C
residue 46
type
sequence K
description BINDING SITE FOR RESIDUE GDP C 551
source : AC6
50) chain C
residue 47
type
sequence S
description BINDING SITE FOR RESIDUE GDP C 551
source : AC6
51) chain C
residue 48
type
sequence T
description BINDING SITE FOR RESIDUE GDP C 551
source : AC6
52) chain C
residue 151
type
sequence S
description BINDING SITE FOR RESIDUE GDP C 551
source : AC6
53) chain C
residue 175
type
sequence L
description BINDING SITE FOR RESIDUE GDP C 551
source : AC6
54) chain C
residue 176
type
sequence R
description BINDING SITE FOR RESIDUE GDP C 551
source : AC6
55) chain C
residue 177
type
sequence T
description BINDING SITE FOR RESIDUE GDP C 551
source : AC6
56) chain C
residue 178
type
sequence R
description BINDING SITE FOR RESIDUE GDP C 551
source : AC6
57) chain C
residue 269
type
sequence N
description BINDING SITE FOR RESIDUE GDP C 551
source : AC6
58) chain C
residue 270
type
sequence K
description BINDING SITE FOR RESIDUE GDP C 551
source : AC6
59) chain C
residue 272
type
sequence D
description BINDING SITE FOR RESIDUE GDP C 551
source : AC6
60) chain C
residue 273
type
sequence L
description BINDING SITE FOR RESIDUE GDP C 551
source : AC6
61) chain C
residue 325
type
sequence C
description BINDING SITE FOR RESIDUE GDP C 551
source : AC6
62) chain C
residue 326
type
sequence A
description BINDING SITE FOR RESIDUE GDP C 551
source : AC6
63) chain C
residue 327
type
sequence T
description BINDING SITE FOR RESIDUE GDP C 551
source : AC6
64) chain A
residue 43
type BINDING
sequence E
description BINDING => ECO:0000269|PubMed:21115486, ECO:0007744|PDB:1KJY, ECO:0007744|PDB:1Y3A, ECO:0007744|PDB:2G83, ECO:0007744|PDB:2GTP, ECO:0007744|PDB:2IK8, ECO:0007744|PDB:2OM2, ECO:0007744|PDB:2XNS, ECO:0007744|PDB:3ONW, ECO:0007744|PDB:3QE0, ECO:0007744|PDB:3QI2, ECO:0007744|PDB:3UMR, ECO:0007744|PDB:3UMS, ECO:0007744|PDB:4G5Q
source Swiss-Prot : SWS_FT_FI1
65) chain A
residue 269
type BINDING
sequence N
description BINDING => ECO:0000269|PubMed:21115486, ECO:0007744|PDB:1KJY, ECO:0007744|PDB:1Y3A, ECO:0007744|PDB:2G83, ECO:0007744|PDB:2GTP, ECO:0007744|PDB:2IK8, ECO:0007744|PDB:2OM2, ECO:0007744|PDB:2XNS, ECO:0007744|PDB:3ONW, ECO:0007744|PDB:3QE0, ECO:0007744|PDB:3QI2, ECO:0007744|PDB:3UMR, ECO:0007744|PDB:3UMS, ECO:0007744|PDB:4G5Q
source Swiss-Prot : SWS_FT_FI1
66) chain B
residue 43
type BINDING
sequence E
description BINDING => ECO:0000269|PubMed:21115486, ECO:0007744|PDB:1KJY, ECO:0007744|PDB:1Y3A, ECO:0007744|PDB:2G83, ECO:0007744|PDB:2GTP, ECO:0007744|PDB:2IK8, ECO:0007744|PDB:2OM2, ECO:0007744|PDB:2XNS, ECO:0007744|PDB:3ONW, ECO:0007744|PDB:3QE0, ECO:0007744|PDB:3QI2, ECO:0007744|PDB:3UMR, ECO:0007744|PDB:3UMS, ECO:0007744|PDB:4G5Q
source Swiss-Prot : SWS_FT_FI1
67) chain B
residue 269
type BINDING
sequence N
description BINDING => ECO:0000269|PubMed:21115486, ECO:0007744|PDB:1KJY, ECO:0007744|PDB:1Y3A, ECO:0007744|PDB:2G83, ECO:0007744|PDB:2GTP, ECO:0007744|PDB:2IK8, ECO:0007744|PDB:2OM2, ECO:0007744|PDB:2XNS, ECO:0007744|PDB:3ONW, ECO:0007744|PDB:3QE0, ECO:0007744|PDB:3QI2, ECO:0007744|PDB:3UMR, ECO:0007744|PDB:3UMS, ECO:0007744|PDB:4G5Q
source Swiss-Prot : SWS_FT_FI1
68) chain C
residue 43
type BINDING
sequence E
description BINDING => ECO:0000269|PubMed:21115486, ECO:0007744|PDB:1KJY, ECO:0007744|PDB:1Y3A, ECO:0007744|PDB:2G83, ECO:0007744|PDB:2GTP, ECO:0007744|PDB:2IK8, ECO:0007744|PDB:2OM2, ECO:0007744|PDB:2XNS, ECO:0007744|PDB:3ONW, ECO:0007744|PDB:3QE0, ECO:0007744|PDB:3QI2, ECO:0007744|PDB:3UMR, ECO:0007744|PDB:3UMS, ECO:0007744|PDB:4G5Q
source Swiss-Prot : SWS_FT_FI1
69) chain C
residue 269
type BINDING
sequence N
description BINDING => ECO:0000269|PubMed:21115486, ECO:0007744|PDB:1KJY, ECO:0007744|PDB:1Y3A, ECO:0007744|PDB:2G83, ECO:0007744|PDB:2GTP, ECO:0007744|PDB:2IK8, ECO:0007744|PDB:2OM2, ECO:0007744|PDB:2XNS, ECO:0007744|PDB:3ONW, ECO:0007744|PDB:3QE0, ECO:0007744|PDB:3QI2, ECO:0007744|PDB:3UMR, ECO:0007744|PDB:3UMS, ECO:0007744|PDB:4G5Q
source Swiss-Prot : SWS_FT_FI1
70) chain A
residue 47
type BINDING
sequence S
description BINDING => ECO:0000269|PubMed:18434541, ECO:0000269|PubMed:22383884, ECO:0007744|PDB:3QE0
source Swiss-Prot : SWS_FT_FI2
71) chain A
residue 181
type BINDING
sequence T
description BINDING => ECO:0000269|PubMed:18434541, ECO:0000269|PubMed:22383884, ECO:0007744|PDB:3QE0
source Swiss-Prot : SWS_FT_FI2
72) chain B
residue 47
type BINDING
sequence S
description BINDING => ECO:0000269|PubMed:18434541, ECO:0000269|PubMed:22383884, ECO:0007744|PDB:3QE0
source Swiss-Prot : SWS_FT_FI2
73) chain B
residue 181
type BINDING
sequence T
description BINDING => ECO:0000269|PubMed:18434541, ECO:0000269|PubMed:22383884, ECO:0007744|PDB:3QE0
source Swiss-Prot : SWS_FT_FI2
74) chain C
residue 47
type BINDING
sequence S
description BINDING => ECO:0000269|PubMed:18434541, ECO:0000269|PubMed:22383884, ECO:0007744|PDB:3QE0
source Swiss-Prot : SWS_FT_FI2
75) chain C
residue 181
type BINDING
sequence T
description BINDING => ECO:0000269|PubMed:18434541, ECO:0000269|PubMed:22383884, ECO:0007744|PDB:3QE0
source Swiss-Prot : SWS_FT_FI2
76) chain A
residue 151
type BINDING
sequence S
description BINDING => ECO:0007744|PDB:1KJY, ECO:0007744|PDB:2OM2, ECO:0007744|PDB:2XNS, ECO:0007744|PDB:3ONW, ECO:0007744|PDB:3QE0, ECO:0007744|PDB:3QI2, ECO:0007744|PDB:4G5Q
source Swiss-Prot : SWS_FT_FI3
77) chain B
residue 151
type BINDING
sequence S
description BINDING => ECO:0007744|PDB:1KJY, ECO:0007744|PDB:2OM2, ECO:0007744|PDB:2XNS, ECO:0007744|PDB:3ONW, ECO:0007744|PDB:3QE0, ECO:0007744|PDB:3QI2, ECO:0007744|PDB:4G5Q
source Swiss-Prot : SWS_FT_FI3
78) chain C
residue 151
type BINDING
sequence S
description BINDING => ECO:0007744|PDB:1KJY, ECO:0007744|PDB:2OM2, ECO:0007744|PDB:2XNS, ECO:0007744|PDB:3ONW, ECO:0007744|PDB:3QE0, ECO:0007744|PDB:3QI2, ECO:0007744|PDB:4G5Q
source Swiss-Prot : SWS_FT_FI3
79) chain A
residue 175
type BINDING
sequence L
description BINDING => ECO:0007744|PDB:1KJY, ECO:0007744|PDB:1Y3A, ECO:0007744|PDB:2G83, ECO:0007744|PDB:2GTP, ECO:0007744|PDB:2IK8, ECO:0007744|PDB:2OM2, ECO:0007744|PDB:2XNS, ECO:0007744|PDB:3ONW, ECO:0007744|PDB:3QE0, ECO:0007744|PDB:3QI2, ECO:0007744|PDB:3UMR, ECO:0007744|PDB:3UMS, ECO:0007744|PDB:4G5Q
source Swiss-Prot : SWS_FT_FI4
80) chain B
residue 175
type BINDING
sequence L
description BINDING => ECO:0007744|PDB:1KJY, ECO:0007744|PDB:1Y3A, ECO:0007744|PDB:2G83, ECO:0007744|PDB:2GTP, ECO:0007744|PDB:2IK8, ECO:0007744|PDB:2OM2, ECO:0007744|PDB:2XNS, ECO:0007744|PDB:3ONW, ECO:0007744|PDB:3QE0, ECO:0007744|PDB:3QI2, ECO:0007744|PDB:3UMR, ECO:0007744|PDB:3UMS, ECO:0007744|PDB:4G5Q
source Swiss-Prot : SWS_FT_FI4
81) chain C
residue 175
type BINDING
sequence L
description BINDING => ECO:0007744|PDB:1KJY, ECO:0007744|PDB:1Y3A, ECO:0007744|PDB:2G83, ECO:0007744|PDB:2GTP, ECO:0007744|PDB:2IK8, ECO:0007744|PDB:2OM2, ECO:0007744|PDB:2XNS, ECO:0007744|PDB:3ONW, ECO:0007744|PDB:3QE0, ECO:0007744|PDB:3QI2, ECO:0007744|PDB:3UMR, ECO:0007744|PDB:3UMS, ECO:0007744|PDB:4G5Q
source Swiss-Prot : SWS_FT_FI4
82) chain B
residue 204
type MOD_RES
sequence Q
description Deamidated glutamine; by Photorhabdus PAU_02230 => ECO:0000269|PubMed:24141704
source Swiss-Prot : SWS_FT_FI8
83) chain C
residue 204
type MOD_RES
sequence Q
description Deamidated glutamine; by Photorhabdus PAU_02230 => ECO:0000269|PubMed:24141704
source Swiss-Prot : SWS_FT_FI8
84) chain A
residue 351
type MOD_RES
sequence C
description ADP-ribosylcysteine; by pertussis toxin => ECO:0000250
source Swiss-Prot : SWS_FT_FI9
85) chain A
residue 326
type BINDING
sequence A
description BINDING => ECO:0007744|PDB:1Y3A, ECO:0007744|PDB:2G83, ECO:0007744|PDB:2GTP, ECO:0007744|PDB:2IK8, ECO:0007744|PDB:2OM2, ECO:0007744|PDB:3ONW, ECO:0007744|PDB:3QE0, ECO:0007744|PDB:3QI2, ECO:0007744|PDB:3UMR, ECO:0007744|PDB:3UMS, ECO:0007744|PDB:4G5Q
source Swiss-Prot : SWS_FT_FI6
86) chain B
residue 326
type BINDING
sequence A
description BINDING => ECO:0007744|PDB:1Y3A, ECO:0007744|PDB:2G83, ECO:0007744|PDB:2GTP, ECO:0007744|PDB:2IK8, ECO:0007744|PDB:2OM2, ECO:0007744|PDB:3ONW, ECO:0007744|PDB:3QE0, ECO:0007744|PDB:3QI2, ECO:0007744|PDB:3UMR, ECO:0007744|PDB:3UMS, ECO:0007744|PDB:4G5Q
source Swiss-Prot : SWS_FT_FI6
87) chain C
residue 326
type BINDING
sequence A
description BINDING => ECO:0007744|PDB:1Y3A, ECO:0007744|PDB:2G83, ECO:0007744|PDB:2GTP, ECO:0007744|PDB:2IK8, ECO:0007744|PDB:2OM2, ECO:0007744|PDB:3ONW, ECO:0007744|PDB:3QE0, ECO:0007744|PDB:3QI2, ECO:0007744|PDB:3UMR, ECO:0007744|PDB:3UMS, ECO:0007744|PDB:4G5Q
source Swiss-Prot : SWS_FT_FI6
88) chain A
residue 178
type MOD_RES
sequence R
description ADP-ribosylarginine; by cholera toxin => ECO:0000250
source Swiss-Prot : SWS_FT_FI7
89) chain B
residue 178
type MOD_RES
sequence R
description ADP-ribosylarginine; by cholera toxin => ECO:0000250
source Swiss-Prot : SWS_FT_FI7
90) chain C
residue 178
type MOD_RES
sequence R
description ADP-ribosylarginine; by cholera toxin => ECO:0000250
source Swiss-Prot : SWS_FT_FI7
91) chain A
residue 200
type BINDING
sequence D
description BINDING => ECO:0000269|PubMed:21115486
source Swiss-Prot : SWS_FT_FI5
92) chain B
residue 200
type BINDING
sequence D
description BINDING => ECO:0000269|PubMed:21115486
source Swiss-Prot : SWS_FT_FI5
93) chain C
residue 200
type BINDING
sequence D
description BINDING => ECO:0000269|PubMed:21115486
source Swiss-Prot : SWS_FT_FI5

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