|
|
eF-site ID
|
3qd2-B |
|
PDB Code
|
3qd2 |
|
Chain
|
B |
|
click to enlarge
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Title
|
Crystal structure of mouse PERK kinase domain |
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Classification
|
GENE REGULATION |
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Compound
|
Eukaryotic translation initiation factor 2-alpha kinase 3 |
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Source
|
(E2AK3_MOUSE) |
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Sequence
|
B: |
ASRYLTDFEPIQCMGRGFGVVFEAKNKVDDCNYAIKRIRL
PNRELAREKVMREVKALAKLEHPGIVRYFNAWLETPPEKW
QEEMDEPKVYLYIQMQLCRKENLKDWMNRRCSLEDREHGV
CLHIFIQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKV
GDFGLVTAMDQDTHXGQVTKLYMSPEQIHGNNYSHKVDIF
SLGLILFELLYSFSTQMERVRIITDVRNLKFPLLFTQKYP
QEHMMVQDMLSPSPTERPEATDIIENAIFENL
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Description
|
(1) |
Eukaryotic translation initiation factor 2-alpha kinase 3 (E.C.2.7.11.1)
|
|
Functional site
|
|
|
1)
|
chain |
B |
| residue |
595 |
| type |
BINDING |
| sequence |
M
|
| description |
BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
2)
|
chain |
B |
| residue |
615 |
| type |
MOD_RES |
| sequence |
Y
|
| description |
Phosphotyrosine => ECO:0000250|UniProtKB:Q9NZJ5
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|
|
3)
|
chain |
B |
| residue |
980 |
| type |
MOD_RES |
| sequence |
X
|
| description |
Phosphothreonine => ECO:0000269|PubMed:21543844
|
| source |
Swiss-Prot : SWS_FT_FI6
|
|
|
4)
|
chain |
B |
| residue |
931-943 |
| type |
prosite |
| sequence |
LMHRDLKPSNIFF
|
| description |
PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. LmHrDLKpsNIFF
|
| source |
prosite : PS00108
|
|
|
5)
|
chain |
B |
| residue |
935 |
| type |
ACT_SITE |
| sequence |
D
|
| description |
Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
6)
|
chain |
B |
| residue |
618 |
| type |
BINDING |
| sequence |
K
|
| description |
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
|