eF-site ID 3qae-A PDB Code 3qae Chain A click to enlarge Title 3-hydroxy-3-methylglutaryl-coenzyme A reductase of Streptococcus pneumoniae Classification OXIDOREDUCTASE Compound 3-hydroxy-3-methylglutaryl-coenzyme a reductase Source Streptococcus pneumoniae (strain ATCC BAA-255 / R6) (Q8DNS5_STRR6) Sequence A:  ISWNGFSKKSYQERLELLKAQALLSPERQASLEKDEQMSV TVADQLSENVVGTFSLPYSLVPEVLVNGQEYTVPYVTEEP SVVAAASYASKIIKRAGGFTTQVHQRQMIGQVALYQVANP KLAQEKIASKKAELLELANQAYPSIVKRGGGARDLHVEQI KGEPDFLVVYIHVDTQEAMGANMLNTMLEALKPVLEELSQ GQSLMGILSNYATDSLVTASCRIAFRYLSRQKDQGREIAE KIALASQFAQADPYRAATHNKGIFNGIDAILIATGNDWRA IEAGAHAFASRDGRYQGLSCWTLDLEREELVGEMTLPMPV ATKGSSIGLNPRVALSHDLLGNPSARELAQIIVSIGLAQN FAALKALVST Description Functional site 1) chain A residue 81 type sequence E description BINDING SITE FOR RESIDUE CIT A 502 source : AC1 2) chain A residue 257 type sequence R description BINDING SITE FOR RESIDUE CIT A 502 source : AC1 3) chain A residue 260 type sequence T description BINDING SITE FOR RESIDUE CIT A 502 source : AC1 4) chain A residue 263 type sequence K description BINDING SITE FOR RESIDUE CIT A 502 source : AC1 5) chain A residue 264 type sequence G description BINDING SITE FOR RESIDUE CIT A 502 source : AC1 6) chain A residue 267 type sequence N description BINDING SITE FOR RESIDUE CIT A 502 source : AC1 7) chain A residue 365 type sequence A description BINDING SITE FOR RESIDUE CIT A 502 source : AC1 8) chain A residue 369 type sequence L description BINDING SITE FOR RESIDUE CIT A 502 source : AC1 9) chain A residue 144 type sequence Y description BINDING SITE FOR RESIDUE GOL A 501 source : AC2 10) chain A residue 150 type sequence R description BINDING SITE FOR RESIDUE GOL A 501 source : AC2 11) chain A residue 182 type sequence G description BINDING SITE FOR RESIDUE GOL A 501 source : AC2 12) chain A residue 185 type sequence M description BINDING SITE FOR RESIDUE GOL A 501 source : AC2 13) chain A residue 325 type sequence K description BINDING SITE FOR RESIDUE GOL A 501 source : AC2 14) chain A residue 105 type sequence V description BINDING SITE FOR RESIDUE NA A 997 source : AC3 15) chain A residue 107 type sequence Q description BINDING SITE FOR RESIDUE NA A 997 source : AC3 16) chain A residue 217 type sequence S description BINDING SITE FOR RESIDUE NA A 997 source : AC3 17) chain A residue 219 type sequence V description BINDING SITE FOR RESIDUE NA A 997 source : AC3 18) chain A residue 274 type sequence I description BINDING SITE FOR RESIDUE NA A 998 source : AC4 19) chain A residue 277 type sequence G description BINDING SITE FOR RESIDUE NA A 998 source : AC4 20) chain A residue 328 type sequence S description BINDING SITE FOR RESIDUE NA A 998 source : AC4 21) chain A residue 283 type sequence I description BINDING SITE FOR RESIDUE NA A 999 source : AC5 22) chain A residue 286 type sequence G description BINDING SITE FOR RESIDUE NA A 999 source : AC5 23) chain A residue 287 type sequence A description BINDING SITE FOR RESIDUE NA A 999 source : AC5 24) chain A residue 319 type sequence P description BINDING SITE FOR RESIDUE NA A 999 source : AC5 25) chain A residue 87 type sequence A description BINDING SITE FOR RESIDUE NA A 1000 source : AC6 26) chain A residue 361 type sequence Q description BINDING SITE FOR RESIDUE NA A 1000 source : AC6 27) chain A residue 365 type sequence A description BINDING SITE FOR RESIDUE NA A 1000 source : AC6 28) chain A residue 113 type sequence Q description BINDING SITE FOR RESIDUE NA A 1002 source : AC8 29) chain A residue 209 type sequence I description BINDING SITE FOR RESIDUE NA A 1002 source : AC8 30) chain A residue 210 type sequence L description BINDING SITE FOR RESIDUE NA A 1002 source : AC8 31) chain A residue 256 type sequence Y description BINDING SITE FOR RESIDUE NA A 1002 source : AC8 32) chain A residue 257 type sequence R description BINDING SITE FOR RESIDUE NA A 1002 source : AC8 33) chain A residue 260 type sequence T description BINDING SITE FOR RESIDUE NA A 1002 source : AC8 34) chain A residue 49 type sequence S description BINDING SITE FOR RESIDUE NA A 1003 source : AC9 35) chain A residue 50 type sequence E description BINDING SITE FOR RESIDUE NA A 1003 source : AC9 36) chain A residue 81 type sequence E description BINDING SITE FOR RESIDUE NA A 1003 source : AC9 37) chain A residue 83 type sequence S description BINDING SITE FOR RESIDUE NA A 1003 source : AC9 38) chain A residue 84 type sequence V description BINDING SITE FOR RESIDUE NA A 1003 source : AC9 39) chain A residue 85 type sequence V description BINDING SITE FOR RESIDUE NA A 1003 source : AC9 40) chain A residue 27 type sequence S description BINDING SITE FOR RESIDUE NA A 1004 source : BC1 41) chain A residue 28 type sequence P description BINDING SITE FOR RESIDUE NA A 1004 source : BC1 42) chain A residue 29 type sequence E description BINDING SITE FOR RESIDUE NA A 1004 source : BC1 43) chain A residue 222 type sequence S description BINDING SITE FOR RESIDUE NA A 1004 source : BC1 44) chain A residue 107 type sequence Q description BINDING SITE FOR RESIDUE NA A 1005 source : BC2 45) chain A residue 215 type sequence T description BINDING SITE FOR RESIDUE NA A 1005 source : BC2 46) chain A residue 216 type sequence D description BINDING SITE FOR RESIDUE NA A 1005 source : BC2 47) chain A residue 217 type sequence S description BINDING SITE FOR RESIDUE NA A 1005 source : BC2 48) chain A residue 218 type sequence L description BINDING SITE FOR RESIDUE NA A 1005 source : BC2 49) chain A residue 263 type sequence K description BINDING SITE FOR RESIDUE NA A 1006 source : BC3 50) chain A residue 266 type sequence F description BINDING SITE FOR RESIDUE NA A 1006 source : BC3 51) chain A residue 281 type sequence R description BINDING SITE FOR RESIDUE NA A 1006 source : BC3 52) chain A residue 284 type sequence E description BINDING SITE FOR RESIDUE NA A 1006 source : BC3 53) chain A residue 288 type sequence H description BINDING SITE FOR RESIDUE NA A 1006 source : BC3 54) chain A residue 49 type sequence S description BINDING SITE FOR RESIDUE NA A 1007 source : BC4 55) chain A residue 59 type sequence P description BINDING SITE FOR RESIDUE NA A 1007 source : BC4 56) chain A residue 61 type sequence S description BINDING SITE FOR RESIDUE NA A 1007 source : BC4 57) chain A residue 77 type sequence Y description BINDING SITE FOR RESIDUE NA A 1007 source : BC4 58) chain A residue 79 type sequence T description BINDING SITE FOR RESIDUE NA A 1007 source : BC4 59) chain A residue 261 type sequence H description BINDING SITE FOR RESIDUE NA A 1008 source : BC5 60) chain A residue 264 type sequence G description BINDING SITE FOR RESIDUE NA A 1008 source : BC5 61) chain A residue 362 type sequence N description BINDING SITE FOR RESIDUE NA A 1008 source : BC5 62) chain A residue 365 type sequence A description BINDING SITE FOR RESIDUE NA A 1008 source : BC5 63) chain A residue 248 type sequence S description BINDING SITE FOR RESIDUE NA A 1009 source : BC6 64) chain A residue 251 type sequence A description BINDING SITE FOR RESIDUE NA A 1009 source : BC6 65) chain A residue 252 type sequence Q description BINDING SITE FOR RESIDUE NA A 1009 source : BC6 66) chain A residue 301 type sequence S description BINDING SITE FOR RESIDUE NA A 1009 source : BC6 67) chain A residue 212 type sequence N description BINDING SITE FOR RESIDUE NA A 1010 source : BC7 68) chain A residue 282 type sequence A description BINDING SITE FOR RESIDUE NA A 1010 source : BC7 69) chain A residue 321 type sequence P description BINDING SITE FOR RESIDUE NA A 1010 source : BC7 70) chain A residue 13 type sequence Y description BINDING SITE FOR RESIDUE NA A 1011 source : BC8 71) chain A residue 34 type sequence L description BINDING SITE FOR RESIDUE NA A 1011 source : BC8 72) chain A residue 37 type sequence D description BINDING SITE FOR RESIDUE NA A 1011 source : BC8 73) chain A residue 53 type sequence V description BINDING SITE FOR RESIDUE NA A 1011 source : BC8 74) chain A residue 54 type sequence G description BINDING SITE FOR RESIDUE NA A 1011 source : BC8 75) chain A residue 108 type sequence R description BINDING SITE FOR RESIDUE NA A 1012 source : BC9 76) chain A residue 177 type sequence T description BINDING SITE FOR RESIDUE NA A 1012 source : BC9 77) chain A residue 33 type sequence S description BINDING SITE FOR RESIDUE NA A 1013 source : CC1 78) chain A residue 38 type sequence E description BINDING SITE FOR RESIDUE NA A 1013 source : CC1 79) chain A residue 334 type sequence R description BINDING SITE FOR RESIDUE NA A 1013 source : CC1 80) chain A residue 111 type sequence I description BINDING SITE FOR RESIDUE NA A 1014 source : CC2 81) chain A residue 211 type sequence S description BINDING SITE FOR RESIDUE NA A 1014 source : CC2 82) chain A residue 214 type sequence A description BINDING SITE FOR RESIDUE NA A 1014 source : CC2 83) chain A residue 108 type sequence R description BINDING SITE FOR RESIDUE NA A 1015 source : CC3 84) chain A residue 320 type sequence M description BINDING SITE FOR RESIDUE NA A 1015 source : CC3 85) chain A residue 351 type sequence A description BINDING SITE FOR RESIDUE NA A 1015 source : CC3 86) chain A residue 80 type sequence E description BINDING SITE FOR RESIDUE NA A 1016 source : CC4 87) chain A residue 278 type sequence N description BINDING SITE FOR RESIDUE NA A 1016 source : CC4 88) chain A residue 280 type sequence W description BINDING SITE FOR RESIDUE NA A 1016 source : CC4 89) chain A residue 247 type sequence A description BINDING SITE FOR RESIDUE NA A 1017 source : CC5 90) chain A residue 251 type sequence A description BINDING SITE FOR RESIDUE NA A 1017 source : CC5 91) chain A residue 257 type sequence R description BINDING SITE FOR RESIDUE NA A 1017 source : CC5 92) chain A residue 261 type sequence H description BINDING SITE FOR RESIDUE NA A 1017 source : CC5 93) chain A residue 366 type sequence L description BINDING SITE FOR RESIDUE NA A 1017 source : CC5 94) chain A residue 212 type sequence N description BINDING SITE FOR RESIDUE NA A 1018 source : CC6 95) chain A residue 282 type sequence A description BINDING SITE FOR RESIDUE NA A 1018 source : CC6 96) chain A residue 321 type sequence P description BINDING SITE FOR RESIDUE NA A 1018 source : CC6 97) chain A residue 58 type sequence L description BINDING SITE FOR RESIDUE NA A 1019 source : CC7 98) chain A residue 328 type sequence S description BINDING SITE FOR RESIDUE NA A 1019 source : CC7 99) chain A residue 332 type sequence N description BINDING SITE FOR RESIDUE NA A 1019 source : CC7 100) chain A residue 9 type sequence S description BINDING SITE FOR RESIDUE NA A 1020 source : CC8 101) chain A residue 16 type sequence R description BINDING SITE FOR RESIDUE NA A 1020 source : CC8 102) chain A residue 50 type sequence E description BINDING SITE FOR RESIDUE NA A 1020 source : CC8 103) chain A residue 51 type sequence N description BINDING SITE FOR RESIDUE NA A 1020 source : CC8 104) chain A residue 13 type sequence Y description BINDING SITE FOR RESIDUE NA A 1021 source : CC9 105) chain A residue 46 type sequence D description BINDING SITE FOR RESIDUE NA A 1021 source : CC9 106) chain A residue 14 type sequence Q description BINDING SITE FOR RESIDUE NA A 1022 source : DC1 107) chain A residue 344 type sequence N description BINDING SITE FOR RESIDUE NA A 1023 source : DC2

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