|
|
eF-site ID
|
3q52-A |
|
PDB Code
|
3q52 |
|
Chain
|
A |
|
click to enlarge
|
|
|
Title
|
Structure of phosphorylated PAK1 kinase domain |
|
Classification
|
TRANSFERASE |
|
Compound
|
Serine/threonine-protein kinase PAK 1 |
|
Source
|
Homo sapiens (Human) (PAK1_HUMAN) |
|
|
Sequence
|
A: |
DEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAMD
VATGQEVAIRQMNLQQQPKKELIINEILVMRENKNPNIVN
YLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAV
CRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFG
FCAQITPEQSKRSXMVGTPYWMAPEVVTRKAYGPKVDIWS
LGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPEK
LSAIFRDFLNRCLEMDVEKRGSAKELIQHQFLKIAKPLSS
LTPLIAAAKEATK
|
|
|
Description
|
|
Functional site
|
|
|
1)
|
chain |
A |
| residue |
385-397 |
| type |
prosite |
| sequence |
VIHRDIKSDNILL
|
| description |
PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. ViHrDIKsdNILL
|
| source |
prosite : PS00108
|
|
|
2)
|
chain |
A |
| residue |
389 |
| type |
ACT_SITE |
| sequence |
D
|
| description |
Proton acceptor => ECO:0000269|PubMed:22153498
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
3)
|
chain |
A |
| residue |
276 |
| type |
BINDING |
| sequence |
I
|
| description |
BINDING => ECO:0000269|PubMed:22153498
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
4)
|
chain |
A |
| residue |
299 |
| type |
BINDING |
| sequence |
R
|
| description |
BINDING => ECO:0000269|PubMed:22153498
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
5)
|
chain |
A |
| residue |
345 |
| type |
BINDING |
| sequence |
E
|
| description |
BINDING => ECO:0000269|PubMed:22153498
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
6)
|
chain |
A |
| residue |
285 |
| type |
MOD_RES |
| sequence |
Y
|
| description |
Phosphotyrosine; by JAK2 => ECO:0000269|PubMed:17726028, ECO:0000269|PubMed:17989089
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
7)
|
chain |
A |
| residue |
423 |
| type |
MOD_RES |
| sequence |
X
|
| description |
Phosphothreonine; by autocatalysis, BRSK2 and PDPK1 => ECO:0000269|PubMed:10551809, ECO:0000269|PubMed:10995762, ECO:0000269|PubMed:22153498, ECO:0000269|PubMed:22669945
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|
|
|