eF-site ID 3q52-A
PDB Code 3q52
Chain A

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Title Structure of phosphorylated PAK1 kinase domain
Classification TRANSFERASE
Compound Serine/threonine-protein kinase PAK 1
Source Homo sapiens (Human) (PAK1_HUMAN)
Sequence A:  DEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAMD
VATGQEVAIRQMNLQQQPKKELIINEILVMRENKNPNIVN
YLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAV
CRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFG
FCAQITPEQSKRSXMVGTPYWMAPEVVTRKAYGPKVDIWS
LGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPEK
LSAIFRDFLNRCLEMDVEKRGSAKELIQHQFLKIAKPLSS
LTPLIAAAKEATK
Description


Functional site

1) chain A
residue 385-397
type prosite
sequence VIHRDIKSDNILL
description PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. ViHrDIKsdNILL
source prosite : PS00108

2) chain A
residue 389
type ACT_SITE
sequence D
description Proton acceptor => ECO:0000269|PubMed:22153498
source Swiss-Prot : SWS_FT_FI1

3) chain A
residue 276
type BINDING
sequence I
description BINDING => ECO:0000269|PubMed:22153498
source Swiss-Prot : SWS_FT_FI2

4) chain A
residue 299
type BINDING
sequence R
description BINDING => ECO:0000269|PubMed:22153498
source Swiss-Prot : SWS_FT_FI2

5) chain A
residue 345
type BINDING
sequence E
description BINDING => ECO:0000269|PubMed:22153498
source Swiss-Prot : SWS_FT_FI2

6) chain A
residue 285
type MOD_RES
sequence Y
description Phosphotyrosine; by JAK2 => ECO:0000269|PubMed:17726028, ECO:0000269|PubMed:17989089
source Swiss-Prot : SWS_FT_FI3

7) chain A
residue 423
type MOD_RES
sequence X
description Phosphothreonine; by autocatalysis, BRSK2 and PDPK1 => ECO:0000269|PubMed:10551809, ECO:0000269|PubMed:10995762, ECO:0000269|PubMed:22153498, ECO:0000269|PubMed:22669945
source Swiss-Prot : SWS_FT_FI4


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