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|
eF-site ID
|
3q4c-B |
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PDB Code
|
3q4c |
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Chain
|
B |
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click to enlarge
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Title
|
Crystal Structure of Wild Type BRAF kinase domain in complex with organometallic inhibitor CNS292 |
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Classification
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TRANSFERASE/TRANSFERASE INHIBITOR |
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Compound
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Serine/threonine-protein kinase B-raf |
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Source
|
Homo sapiens (Human) (BRAF_HUMAN) |
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Sequence
|
B: |
DDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNV
TAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAI
VTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYL
HAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSGSILW
MAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNI
NNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKK
KRDERPLFPQILASIELLARSLPK
|
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Description
|
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Functional site
|
|
|
1)
|
chain |
B |
| residue |
575 |
| type |
ACT_SITE |
| sequence |
D
|
| description |
Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
2)
|
chain |
B |
| residue |
462 |
| type |
BINDING |
| sequence |
I
|
| description |
BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
3)
|
chain |
B |
| residue |
482 |
| type |
BINDING |
| sequence |
K
|
| description |
BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
4)
|
chain |
B |
| residue |
670 |
| type |
MOD_RES |
| sequence |
R
|
| description |
Omega-N-methylarginine; by PRMT5 => ECO:0000269|PubMed:21917714
|
| source |
Swiss-Prot : SWS_FT_FI6
|
|
|
5)
|
chain |
B |
| residue |
577 |
| type |
CROSSLNK |
| sequence |
K
|
| description |
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:23907581
|
| source |
Swiss-Prot : SWS_FT_FI7
|
|
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