eF-site ID 3q4c-B
PDB Code 3q4c
Chain B

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Title Crystal Structure of Wild Type BRAF kinase domain in complex with organometallic inhibitor CNS292
Classification TRANSFERASE/TRANSFERASE INHIBITOR
Compound Serine/threonine-protein kinase B-raf
Source Homo sapiens (Human) (BRAF_HUMAN)
Sequence B:  DDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNV
TAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAI
VTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYL
HAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSGSILW
MAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNI
NNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKK
KRDERPLFPQILASIELLARSLPK
Description


Functional site

1) chain B
residue 575
type ACT_SITE
sequence D
description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027
source Swiss-Prot : SWS_FT_FI1

2) chain B
residue 462
type BINDING
sequence I
description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
source Swiss-Prot : SWS_FT_FI2

3) chain B
residue 482
type BINDING
sequence K
description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
source Swiss-Prot : SWS_FT_FI2

4) chain B
residue 670
type MOD_RES
sequence R
description Omega-N-methylarginine; by PRMT5 => ECO:0000269|PubMed:21917714
source Swiss-Prot : SWS_FT_FI6

5) chain B
residue 577
type CROSSLNK
sequence K
description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:23907581
source Swiss-Prot : SWS_FT_FI7


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