eF-site ID 3q4c-A PDB Code 3q4c Chain A click to enlarge Title Crystal Structure of Wild Type BRAF kinase domain in complex with organometallic inhibitor CNS292 Classification TRANSFERASE/TRANSFERASE INHIBITOR Compound Serine/threonine-protein kinase B-raf Source Homo sapiens (Human) (BRAF_HUMAN) Sequence A:  DDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNV TAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAI VTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYL HAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSGSILW MAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNI NNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKK KRDERPLFPQILASIELLARSLPK Description Functional site 1) chain A residue 462 type sequence I description BINDING SITE FOR RESIDUE RSW A 1 source : AC1 2) chain A residue 530 type sequence W description BINDING SITE FOR RESIDUE RSW A 1 source : AC1 3) chain A residue 531 type sequence C description BINDING SITE FOR RESIDUE RSW A 1 source : AC1 4) chain A residue 533 type sequence G description BINDING SITE FOR RESIDUE RSW A 1 source : AC1 5) chain A residue 534 type sequence S description BINDING SITE FOR RESIDUE RSW A 1 source : AC1 6) chain A residue 538 type sequence H description BINDING SITE FOR RESIDUE RSW A 1 source : AC1 7) chain A residue 582 type sequence F description BINDING SITE FOR RESIDUE RSW A 1 source : AC1 8) chain A residue 575 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027 source Swiss-Prot : SWS_FT_FI1 9) chain A residue 462 type BINDING sequence I description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 10) chain A residue 482 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 11) chain A residue 670 type MOD_RES sequence R description Omega-N-methylarginine; by PRMT5 => ECO:0000269|PubMed:21917714 source Swiss-Prot : SWS_FT_FI6 12) chain A residue 577 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:23907581 source Swiss-Prot : SWS_FT_FI7 13) chain A residue 462-482 type prosite sequence IGSGSFGTVYKGKWHGDVAVK description PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGSGSFGTVYkGkwhgd.............VAVK source prosite : PS00107 14) chain A residue 571-583 type prosite sequence IIHRDLKSNNIFL description PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IiHrDLKsnNIFL source prosite : PS00108

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