eF-site ID 3q2z-A PDB Code 3q2z Chain A click to enlarge Title Human Squalene synthase in complex with N-[(3R,5S)-7-Chloro-5-(2,3-dimethoxyphenyl)-1-neopentyl-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepine-3-acetyl]-L-aspartic acid Classification TRANSFERASE/TRANSFERASE INHIBITOR Compound Squalene synthase Source Homo sapiens (Human) (FDFT_HUMAN) Sequence A:  LSSSLKTCYKYLNQTSRSFAAVIQALDGEMRNAVCIFYLV LRALDTLEDDMTISVEKKVPLLHNFHSFLYQPDWRFMESK EKDRQVLEDFPTISLEFRNLAEKYQTVIADICRRMGIGMA EFLDKHVTSEQEWDKYCHYVAGLVGIGLSRLFSASEFEDP LVGEDTERANSMGLFLQKTNIIRDYLEDQQGGREFWPQEV WSRYVKKLGDFAKPENIDLAVQCLNELITNALHHIPDVIT YLSRLRNQSVFNFCAIPQVMAIATLAACYNNQQVFKGAVK IRKGQAVTLMMDATNMPAVKAIIYQYMEEIYHRIPDSDPS SSKTRQIISTIRT Description Functional site 1) chain A residue 148 type sequence R description BINDING SITE FOR RESIDUE PO4 A 1 source : AC1 2) chain A residue 149 type sequence R description BINDING SITE FOR RESIDUE PO4 A 1 source : AC1 3) chain A residue 173 type sequence H description BINDING SITE FOR RESIDUE PO4 A 1 source : AC1 4) chain A residue 174 type sequence Y description BINDING SITE FOR RESIDUE PO4 A 1 source : AC1 5) chain A residue 51 type sequence S description BINDING SITE FOR RESIDUE D9A A 700 source : AC2 6) chain A residue 73 type sequence Y description BINDING SITE FOR RESIDUE D9A A 700 source : AC2 7) chain A residue 180 type sequence G description BINDING SITE FOR RESIDUE D9A A 700 source : AC2 8) chain A residue 183 type sequence L description BINDING SITE FOR RESIDUE D9A A 700 source : AC2 9) chain A residue 208 type sequence G description BINDING SITE FOR RESIDUE D9A A 700 source : AC2 10) chain A residue 211 type sequence L description BINDING SITE FOR RESIDUE D9A A 700 source : AC2 11) chain A residue 212 type sequence Q description BINDING SITE FOR RESIDUE D9A A 700 source : AC2 12) chain A residue 276 type sequence Y description BINDING SITE FOR RESIDUE D9A A 700 source : AC2 13) chain A residue 288 type sequence F description BINDING SITE FOR RESIDUE D9A A 700 source : AC2 14) chain A residue 171 type catalytic sequence Y description 264 source MCSA : MCSA1 15) chain A residue 218 type catalytic sequence R description 264 source MCSA : MCSA1 16) chain A residue 228 type catalytic sequence R description 264 source MCSA : MCSA1 17) chain A residue 288 type catalytic sequence F description 264 source MCSA : MCSA1 18) chain A residue 52 type BINDING sequence R description BINDING => ECO:0000305|PubMed:24531458 source Swiss-Prot : SWS_FT_FI2 19) chain A residue 77 type BINDING sequence R description BINDING => ECO:0000305|PubMed:24531458 source Swiss-Prot : SWS_FT_FI2 20) chain A residue 218 type BINDING sequence R description BINDING => ECO:0000305|PubMed:24531458 source Swiss-Prot : SWS_FT_FI2 21) chain A residue 315 type BINDING sequence K description BINDING => ECO:0000305|PubMed:24531458 source Swiss-Prot : SWS_FT_FI2 22) chain A residue 317 type BINDING sequence R description BINDING => ECO:0000305|PubMed:24531458 source Swiss-Prot : SWS_FT_FI2 23) chain A residue 284-304 type TRANSMEM sequence SVFNFCAIPQVMAIATLAACY description Helical => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 24) chain A residue 80 type BINDING sequence D description BINDING => ECO:0000269|PubMed:24531458, ECO:0007744|PDB:3WEG, ECO:0007744|PDB:3WEH source Swiss-Prot : SWS_FT_FI3 25) chain A residue 83 type BINDING sequence E description BINDING => ECO:0000269|PubMed:24531458, ECO:0007744|PDB:3WEG, ECO:0007744|PDB:3WEH source Swiss-Prot : SWS_FT_FI3 26) chain A residue 84 type BINDING sequence D description BINDING => ECO:0000269|PubMed:24531458, ECO:0007744|PDB:3WEG, ECO:0007744|PDB:3WEH source Swiss-Prot : SWS_FT_FI3 27) chain A residue 171-186 type prosite sequence YCHYVAGLVGIGLSRL description SQUALEN_PHYTOEN_SYN_1 Squalene and phytoene synthases signature 1. YChyVAGLVGigLsrL source prosite : PS01044 28) chain A residue 207-232 type prosite sequence MGLFLQKTNIIRDYLEDQQGGREFWP description SQUALEN_PHYTOEN_SYN_2 Squalene and phytoene synthases signature 2. MGlflQkt.NIiRDYleDqqgg...ReFwP source prosite : PS01045

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