eF-site ID 3q24-AB PDB Code 3q24 Chain A, B click to enlarge Title X-ray crystal structure of the N4 mini-VRNAP and P2_7a promoter transcription initiation complex with pppGpG and pyrophosphate: product complex Classification TRANSFERASE/DNA/RNA Compound Virion RNA polymerase Source (3Q24) Sequence A:  EELKEGIDAVYPSLVGTADSKAEGIKNYFKLSFTLPEEQK SRTVGSEAPLKDVAQALSSRARYELFTEKETANPAFNGEV IKRYKELMEHGEGIADILRSRLAKFLNTKDVGKRFAQGTE ANRWVGGKLLNIVEQDGDTFKYNEQLLQTAVLAGLQWRLT ATSNTAIKDAKDVAAITGIDQALLPEGLVEQFDTGMTLTE AVSSLAQKIESYWGLSRNPNAPLGYTKGIPTAMAAEILAA FVESTDVVENIVDMSEIDPDNKKTIGLYTITELDSFDPIN SFPTAIEEAVLVNPTEKMFFGDDIPPVANTQLRNPAVRNT PEQKAALKAEQATEFYVHTPMVQFYETLGKDRILELMGAG TLNKELLNDNHAKSLEGKNRSVEDSYNQLFSVIEQVRAQS EDISTVPIHYAYNMTRVGRMQMLGKYNPQSAKLVREAILP TKATLDLSNQNNEDFSAFQLGLAQALDIKVHTMTREVMSD ELTKLLEGNLKPAIDMMVEFNTTGSLPENAVDVLNTALGD RKSFVALMALMEYSRYLVAEDKSAFVTPLYVEADGVTNGP INAMMLMTGGLFTPDWIRNIAKGGLFIGSPNKTMNEHRST ADNNDLYQASTNALMESLGKLRSNYASNMPIQSQIDSLLS LMDLFLPDINLGENGALELKRGIAKNPLTITIYGSGARGI AGKLVSSVTDAIYERMSDVLKARAKDPNISAAMAMFGKQA ASEAHAEELLARFLKDMETLTSTVPVKRKGVLELQSTGTG AKGKINPKTYTIKGEQLKALQENMLHFFVEPLRNGITQTV GESLVYSTEQLQKATQIQSVVLEDMFKQRVQEKLAEKAKD PTWKKGDFLTQKELNDIQASLNNLAPMIETGSQTFYIAGS ENAEVANQVLATNLDDRMRVPMSIYAPAQAGVAGIPFMTI GTGDGMMMQTLSTMKGAPKNTLKIFDGMNIGLNDITDASR KANEAVYTSWQGNPIKNVYESYAKFMKNVDFSKLSPEALE AIGKSALEYDQRENATVDDIANAASLIERNLRNIALGVDI RHKVLDKVNLSIDQMAAVGAPYQNNGKIDLSNMTPEQQAD ELNKLFREELEARKQ B:  TEELKEGIDAVYPSLVGTADSKAEGIKNYFKLSFTLPEEQ KSRTVGSEAPLKDVAQALSSRARYELFTEKETANPAFNGE VIKRYKELMEHGEGIADILRSRLAKFLNTKDVGKRFAQGT EANRWVGGKLLNIVEQDGDTFKYNEQLLQTAVLAGLQWRL TATSNTAIKDAKDVAAITGIDQALLPEGLVEQFDTGMTLT EAVSSLAQKIESYWGLSRNPNAPLGYTKGIPTAMAAEILA AFVESTDVVENIVDMSEIDPDNKKTIGLYTITELDSFDPI NSFPTAIEEAVLVNPTEKMFFGDDIPPVANTQLRNPAVRN TPEQKAALKAEQATEFYVHTPMVQFYETLGKDRILELMGA GTLNKELLNDNHAKSLEGKNRSVEDSYNQLFSVIEQVRAQ SEDISTVPIHYAYNMTRVGRMQMLGKYNPQSAKLVREAIL PTKATLDLSNQNNEDFSAFQLGLAQALDIKVHTMTREVMS DELTKLLEGNLKPAIDMMVEFNTTGSLPENAVDVLNTALG DRKSFVALMALMEYSRYLVAEDKSAFVTPLYVEADGVTNG PINAMMLMTGGLFTPDWIRNIAKGGLFIGSPNKTMNEHRS TADNNDLYQASTNALMESLGKLRSNYASNMPIQSQIDSLL SLMDLFLPDINLGENGALELKRGIAKNPLTITIYGSGARG IAGKLVSSVTDAIYERMSDVLKARAKDPNISAAMAMFGKQ AASEAHAEELLARFLKDMETLTSTVPVKRKGVLELQSTGT GAKGKINPKTYTIKGEQLKALQENMLHFFVEPLRNGITQT VGESLVYSTEQLQKATQIQSVVLEDMFKQRVQEKLAEKAK DPTWKKGDFLTQKELNDIQASLNNLAPMIETGSQTFYIAG SENAEVANQVLATNLDDRMRVPMSIYAPAQAGVAGIPFMT IGTGDGMMMQTLSTMKGAPKNTLKIFDGMNIGLNDITDAS RKANEAVYTSWQGNPIKNVYESYAKFMKNVDFSKLSPEAL EAIGKSALEYDQRENATVDDIANAASLIERNLRNIALGVD IRHKVLDKVNLSIDQMAAVGAPYQNNGKIDLSNMTPEQQA DELNKLFREELEAR Description Functional site 1) chain A residue 424 type sequence R description BINDING SITE FOR RESIDUE GTP A 1106 source : AC1 2) chain A residue 437 type sequence K description BINDING SITE FOR RESIDUE GTP A 1106 source : AC1 3) chain A residue 440 type sequence R description BINDING SITE FOR RESIDUE GTP A 1106 source : AC1 4) chain A residue 949 type sequence I description BINDING SITE FOR RESIDUE GTP A 1106 source : AC1 5) chain A residue 951 type sequence D description BINDING SITE FOR RESIDUE GTP A 1106 source : AC1 6) chain A residue 424 type sequence R description BINDING SITE FOR RESIDUE G A 1107 source : AC2 7) chain A residue 564 type sequence G description BINDING SITE FOR RESIDUE G A 1107 source : AC2 8) chain A residue 565 type sequence P description BINDING SITE FOR RESIDUE G A 1107 source : AC2 9) chain A residue 671 type sequence N description BINDING SITE FOR RESIDUE G A 1107 source : AC2 10) chain A residue 674 type sequence T description BINDING SITE FOR RESIDUE G A 1107 source : AC2 11) chain A residue 678 type sequence Y description BINDING SITE FOR RESIDUE G A 1107 source : AC2 12) chain A residue 951 type sequence D description BINDING SITE FOR RESIDUE G A 1107 source : AC2 13) chain A residue 469 type sequence Q description BINDING SITE FOR RESIDUE 2HP A 1108 source : AC3 14) chain A residue 473 type sequence I description BINDING SITE FOR RESIDUE 2HP A 1108 source : AC3 15) chain A residue 474 type sequence K description BINDING SITE FOR RESIDUE 2HP A 1108 source : AC3 16) chain A residue 475 type sequence V description BINDING SITE FOR RESIDUE 2HP A 1108 source : AC3 17) chain A residue 476 type sequence H description BINDING SITE FOR RESIDUE 2HP A 1108 source : AC3 18) chain A residue 560 type sequence G description BINDING SITE FOR RESIDUE POP A 1109 source : AC4 19) chain A residue 561 type sequence V description BINDING SITE FOR RESIDUE POP A 1109 source : AC4 20) chain A residue 562 type sequence T description BINDING SITE FOR RESIDUE POP A 1109 source : AC4 21) chain A residue 612 type sequence Y description BINDING SITE FOR RESIDUE POP A 1109 source : AC4 22) chain A residue 666 type sequence R description BINDING SITE FOR RESIDUE POP A 1109 source : AC4 23) chain A residue 670 type sequence K description BINDING SITE FOR RESIDUE POP A 1109 source : AC4 24) chain B residue 469 type sequence Q description BINDING SITE FOR RESIDUE 2HP B 1106 source : AC5 25) chain B residue 473 type sequence I description BINDING SITE FOR RESIDUE 2HP B 1106 source : AC5 26) chain B residue 474 type sequence K description BINDING SITE FOR RESIDUE 2HP B 1106 source : AC5 27) chain B residue 475 type sequence V description BINDING SITE FOR RESIDUE 2HP B 1106 source : AC5 28) chain B residue 476 type sequence H description BINDING SITE FOR RESIDUE 2HP B 1106 source : AC5 29) chain B residue 476 type sequence H description BINDING SITE FOR RESIDUE POP B 1107 source : AC6 30) chain B residue 560 type sequence G description BINDING SITE FOR RESIDUE POP B 1107 source : AC6 31) chain B residue 561 type sequence V description BINDING SITE FOR RESIDUE POP B 1107 source : AC6 32) chain B residue 562 type sequence T description BINDING SITE FOR RESIDUE POP B 1107 source : AC6 33) chain B residue 610 type sequence D description BINDING SITE FOR RESIDUE POP B 1107 source : AC6 34) chain B residue 612 type sequence Y description BINDING SITE FOR RESIDUE POP B 1107 source : AC6 35) chain B residue 666 type sequence R description BINDING SITE FOR RESIDUE POP B 1107 source : AC6 36) chain A residue 437 type BINDING sequence K description BINDING => ECO:0000269|PubMed:21321236, ECO:0000269|PubMed:23235152 source Swiss-Prot : SWS_FT_FI1 37) chain A residue 559 type BINDING sequence D description BINDING => ECO:0000269|PubMed:21321236, ECO:0000269|PubMed:23235152 source Swiss-Prot : SWS_FT_FI1 38) chain A residue 670 type BINDING sequence K description BINDING => ECO:0000269|PubMed:21321236, ECO:0000269|PubMed:23235152 source Swiss-Prot : SWS_FT_FI1 39) chain A residue 951 type BINDING sequence D description BINDING => ECO:0000269|PubMed:21321236, ECO:0000269|PubMed:23235152 source Swiss-Prot : SWS_FT_FI1 40) chain B residue 437 type BINDING sequence K description BINDING => ECO:0000269|PubMed:21321236, ECO:0000269|PubMed:23235152 source Swiss-Prot : SWS_FT_FI1 41) chain B residue 559 type BINDING sequence D description BINDING => ECO:0000269|PubMed:21321236, ECO:0000269|PubMed:23235152 source Swiss-Prot : SWS_FT_FI1 42) chain B residue 670 type BINDING sequence K description BINDING => ECO:0000269|PubMed:21321236, ECO:0000269|PubMed:23235152 source Swiss-Prot : SWS_FT_FI1 43) chain B residue 951 type BINDING sequence D description BINDING => ECO:0000269|PubMed:21321236, ECO:0000269|PubMed:23235152 source Swiss-Prot : SWS_FT_FI1

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