eF-site ID 3q23-AB PDB Code 3q23 Chain A, B click to enlarge Title X-ray crystal structure of the N4 mini-VRNAP and P2_7a promoter transcription initiation complex with GMPCPP and Manganese: sustrate complex II Classification TRANSFERASE/DNA Compound Virion RNA polymerase Source (3Q23) Sequence A:  EELKEGIDAVYPSLVGTADSKAEGIKNYFKLSFTLPEEQK SRTVGSEAPLKDVAQALSSRARYELFTEKETANPAFNGEV IKRYKELMEHGEGIADILRSRLAKFLNTKDVGKRFAQGTE ANRWVGGKLLNIVEQDGDTFKYNEQLLQTAVLAGLQWRLT ATSNTAIKDAKDVAAITGIDQALLPEGLVEQFDTGMTLTE AVSSLAQKIESYWGLSRNPNAPLGYTKGIPTAMAAEILAA FVESTDVVENIVDMSEIDPDNKKTIGLYTITELDSFDPIN SFPTAIEEAVLVNPTEKMFFGDDIPPVANTQLRNPAVRNT PEQKAALKAEQATEFYVHTPMVQFYETLGKDRILELMGAG TLNKELLNDNHAKSLEGKNRSVEDSYNQLFSVIEQVRAQS EDISTVPIHYAYNMTRVGRMQMLGKYNPQSAKLVREAILP TKATLDLSNQNNEDFSAFQLGLAQALDIKVHTMTREVMSD ELTKLLEGNLKPAIDMMVEFNTTGSLPENAVDVLNTALGD RKSFVALMALMEYSRYLVAEDKSAFVTPLYVEADGVTNGP INAMMLMTGGLFTPDWIRNIAKGGLFIGSPNKTMNEHRST ADNNDLYQASTNALMESLGKLRSNYASNMPIQSQIDSLLS LMDLFLPDINLGENGALELKRGIAKNPLTITIYGSGARGI AGKLVSSVTDAIYERMSDVLKARAKDPNISAAMAMFGKQA ASEAHAEELLARFLKDMETLTSTVPVKRKGVLELQSTGTG AKGKINPKTYTIKGEQLKALQENMLHFFVEPLRNGITQTV GESLVYSTEQLQKATQIQSVVLEDMFKQRVQEKLAEKAKD PTWKKGDFLTQKELNDIQASLNNLAPMIETGSQTFYIAGS ENAEVANQVLATNLDDRMRVPMSIYAPAQAGVAGIPFMTI GTGDGMMMQTLSTMKGAPKNTLKIFDGMNIGLNDITDASR KANEAVYTSWQGNPIKNVYESYAKFMKNVDFSKLSPEALE AIGKSALEYDQRENATVDDIANAASLIERNLRNIALGVDI RHKVLDKVNLSIDQMAAVGAPYQNNGKIDLSNMTPEQQAD ELNKLFREELEARKQ B:  TEELKEGIDAVYPSLVGTADSKAEGIKNYFKLSFTLPEEQ KSRTVGSEAPLKDVAQALSSRARYELFTEKETANPAFNGE VIKRYKELMEHGEGIADILRSRLAKFLNTKDVGKRFAQGT EANRWVGGKLLNIVEQDGDTFKYNEQLLQTAVLAGLQWRL TATSNTAIKDAKDVAAITGIDQALLPEGLVEQFDTGMTLT EAVSSLAQKIESYWGLSRNPNAPLGYTKGIPTAMAAEILA AFVESTDVVENIVDMSEIDPDNKKTIGLYTITELDSFDPI NSFPTAIEEAVLVNPTEKMFFGDDIPPVANTQLRNPAVRN TPEQKAALKAEQATEFYVHTPMVQFYETLGKDRILELMGA GTLNKELLNDNHAKSLEGKNRSVEDSYNQLFSVIEQVRAQ SEDISTVPIHYAYNMTRVGRMQMLGKYNPQSAKLVREAIL PTKATLDLSNQNNEDFSAFQLGLAQALDIKVHTMTREVMS DELTKLLEGNLKPAIDMMVEFNTTGSLPENAVDVLNTALG DRKSFVALMALMEYSRYLVAEDKSAFVTPLYVEADGVTNG PINAMMLMTGGLFTPDWIRNIAKGGLFIGSPNKTMNEHRS TADNNDLYQASTNALMESLGKLRSNYASNMPIQSQIDSLL SLMDLFLPDINLGENGALELKRGIAKNPLTITIYGSGARG IAGKLVSSVTDAIYERMSDVLKARAKDPNISAAMAMFGKQ AASEAHAEELLARFLKDMETLTSTVPVKRKGVLELQSTGT GAKGKINPKTYTIKGEQLKALQENMLHFFVEPLRNGITQT VGESLVYSTEQLQKATQIQSVVLEDMFKQRVQEKLAEKAK DPTWKKGDFLTQKELNDIQASLNNLAPMIETGSQTFYIAG SENAEVANQVLATNLDDRMRVPMSIYAPAQAGVAGIPFMT IGTGDGMMMQTLSTMKGAPKNTLKIFDGMNIGLNDITDAS RKANEAVYTSWQGNPIKNVYESYAKFMKNVDFSKLSPEAL EAIGKSALEYDQRENATVDDIANAASLIERNLRNIALGVD IRHKVLDKVNLSIDQMAAVGAPYQNNGKIDLSNMTPEQQA DELNKLFREELEAR Description Functional site 1) chain A residue 424 type sequence R description BINDING SITE FOR RESIDUE G2P A 1108 source : AC1 2) chain A residue 559 type sequence D description BINDING SITE FOR RESIDUE G2P A 1108 source : AC1 3) chain A residue 560 type sequence G description BINDING SITE FOR RESIDUE G2P A 1108 source : AC1 4) chain A residue 561 type sequence V description BINDING SITE FOR RESIDUE G2P A 1108 source : AC1 5) chain A residue 562 type sequence T description BINDING SITE FOR RESIDUE G2P A 1108 source : AC1 6) chain A residue 563 type sequence N description BINDING SITE FOR RESIDUE G2P A 1108 source : AC1 7) chain A residue 564 type sequence G description BINDING SITE FOR RESIDUE G2P A 1108 source : AC1 8) chain A residue 565 type sequence P description BINDING SITE FOR RESIDUE G2P A 1108 source : AC1 9) chain A residue 612 type sequence Y description BINDING SITE FOR RESIDUE G2P A 1108 source : AC1 10) chain A residue 666 type sequence R description BINDING SITE FOR RESIDUE G2P A 1108 source : AC1 11) chain A residue 670 type sequence K description BINDING SITE FOR RESIDUE G2P A 1108 source : AC1 12) chain A residue 671 type sequence N description BINDING SITE FOR RESIDUE G2P A 1108 source : AC1 13) chain A residue 678 type sequence Y description BINDING SITE FOR RESIDUE G2P A 1108 source : AC1 14) chain A residue 951 type sequence D description BINDING SITE FOR RESIDUE G2P A 1108 source : AC1 15) chain A residue 559 type sequence D description BINDING SITE FOR RESIDUE MN A 1107 source : AC2 16) chain A residue 951 type sequence D description BINDING SITE FOR RESIDUE MN A 1107 source : AC2 17) chain A residue 559 type sequence D description BINDING SITE FOR RESIDUE MN A 1109 source : AC3 18) chain A residue 560 type sequence G description BINDING SITE FOR RESIDUE MN A 1109 source : AC3 19) chain A residue 951 type sequence D description BINDING SITE FOR RESIDUE MN A 1109 source : AC3 20) chain A residue 469 type sequence Q description BINDING SITE FOR RESIDUE 2HP A 1110 source : AC4 21) chain A residue 473 type sequence I description BINDING SITE FOR RESIDUE 2HP A 1110 source : AC4 22) chain A residue 474 type sequence K description BINDING SITE FOR RESIDUE 2HP A 1110 source : AC4 23) chain A residue 475 type sequence V description BINDING SITE FOR RESIDUE 2HP A 1110 source : AC4 24) chain A residue 476 type sequence H description BINDING SITE FOR RESIDUE 2HP A 1110 source : AC4 25) chain A residue 424 type sequence R description BINDING SITE FOR RESIDUE G2P A 1111 source : AC5 26) chain A residue 437 type sequence K description BINDING SITE FOR RESIDUE G2P A 1111 source : AC5 27) chain A residue 557 type sequence E description BINDING SITE FOR RESIDUE G2P A 1111 source : AC5 28) chain A residue 559 type sequence D description BINDING SITE FOR RESIDUE G2P A 1111 source : AC5 29) chain A residue 925 type sequence I description BINDING SITE FOR RESIDUE G2P A 1111 source : AC5 30) chain A residue 950 type sequence F description BINDING SITE FOR RESIDUE G2P A 1111 source : AC5 31) chain A residue 951 type sequence D description BINDING SITE FOR RESIDUE G2P A 1111 source : AC5 32) chain B residue 424 type sequence R description BINDING SITE FOR RESIDUE G2P B 1108 source : AC6 33) chain B residue 437 type sequence K description BINDING SITE FOR RESIDUE G2P B 1108 source : AC6 34) chain B residue 557 type sequence E description BINDING SITE FOR RESIDUE G2P B 1108 source : AC6 35) chain B residue 559 type sequence D description BINDING SITE FOR RESIDUE G2P B 1108 source : AC6 36) chain B residue 925 type sequence I description BINDING SITE FOR RESIDUE G2P B 1108 source : AC6 37) chain B residue 950 type sequence F description BINDING SITE FOR RESIDUE G2P B 1108 source : AC6 38) chain B residue 951 type sequence D description BINDING SITE FOR RESIDUE G2P B 1108 source : AC6 39) chain B residue 424 type sequence R description BINDING SITE FOR RESIDUE G2P B 1109 source : AC7 40) chain B residue 559 type sequence D description BINDING SITE FOR RESIDUE G2P B 1109 source : AC7 41) chain B residue 560 type sequence G description BINDING SITE FOR RESIDUE G2P B 1109 source : AC7 42) chain B residue 561 type sequence V description BINDING SITE FOR RESIDUE G2P B 1109 source : AC7 43) chain B residue 562 type sequence T description BINDING SITE FOR RESIDUE G2P B 1109 source : AC7 44) chain B residue 563 type sequence N description BINDING SITE FOR RESIDUE G2P B 1109 source : AC7 45) chain B residue 564 type sequence G description BINDING SITE FOR RESIDUE G2P B 1109 source : AC7 46) chain B residue 565 type sequence P description BINDING SITE FOR RESIDUE G2P B 1109 source : AC7 47) chain B residue 612 type sequence Y description BINDING SITE FOR RESIDUE G2P B 1109 source : AC7 48) chain B residue 666 type sequence R description BINDING SITE FOR RESIDUE G2P B 1109 source : AC7 49) chain B residue 670 type sequence K description BINDING SITE FOR RESIDUE G2P B 1109 source : AC7 50) chain B residue 671 type sequence N description BINDING SITE FOR RESIDUE G2P B 1109 source : AC7 51) chain B residue 678 type sequence Y description BINDING SITE FOR RESIDUE G2P B 1109 source : AC7 52) chain B residue 951 type sequence D description BINDING SITE FOR RESIDUE G2P B 1109 source : AC7 53) chain B residue 559 type sequence D description BINDING SITE FOR RESIDUE MN B 1107 source : AC8 54) chain B residue 951 type sequence D description BINDING SITE FOR RESIDUE MN B 1107 source : AC8 55) chain B residue 559 type sequence D description BINDING SITE FOR RESIDUE MN B 1110 source : AC9 56) chain B residue 560 type sequence G description BINDING SITE FOR RESIDUE MN B 1110 source : AC9 57) chain B residue 951 type sequence D description BINDING SITE FOR RESIDUE MN B 1110 source : AC9 58) chain B residue 469 type sequence Q description BINDING SITE FOR RESIDUE 2HP B 1111 source : BC1 59) chain B residue 473 type sequence I description BINDING SITE FOR RESIDUE 2HP B 1111 source : BC1 60) chain B residue 474 type sequence K description BINDING SITE FOR RESIDUE 2HP B 1111 source : BC1 61) chain B residue 475 type sequence V description BINDING SITE FOR RESIDUE 2HP B 1111 source : BC1 62) chain B residue 476 type sequence H description BINDING SITE FOR RESIDUE 2HP B 1111 source : BC1 63) chain A residue 437 type BINDING sequence K description BINDING => ECO:0000269|PubMed:21321236, ECO:0000269|PubMed:23235152 source Swiss-Prot : SWS_FT_FI1 64) chain A residue 559 type BINDING sequence D description BINDING => ECO:0000269|PubMed:21321236, ECO:0000269|PubMed:23235152 source Swiss-Prot : SWS_FT_FI1 65) chain A residue 670 type BINDING sequence K description BINDING => ECO:0000269|PubMed:21321236, ECO:0000269|PubMed:23235152 source Swiss-Prot : SWS_FT_FI1 66) chain A residue 951 type BINDING sequence D description BINDING => ECO:0000269|PubMed:21321236, ECO:0000269|PubMed:23235152 source Swiss-Prot : SWS_FT_FI1 67) chain B residue 437 type BINDING sequence K description BINDING => ECO:0000269|PubMed:21321236, ECO:0000269|PubMed:23235152 source Swiss-Prot : SWS_FT_FI1 68) chain B residue 559 type BINDING sequence D description BINDING => ECO:0000269|PubMed:21321236, ECO:0000269|PubMed:23235152 source Swiss-Prot : SWS_FT_FI1 69) chain B residue 670 type BINDING sequence K description BINDING => ECO:0000269|PubMed:21321236, ECO:0000269|PubMed:23235152 source Swiss-Prot : SWS_FT_FI1 70) chain B residue 951 type BINDING sequence D description BINDING => ECO:0000269|PubMed:21321236, ECO:0000269|PubMed:23235152 source Swiss-Prot : SWS_FT_FI1

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