eF-site ID 3pze-A PDB Code 3pze Chain A click to enlarge Title JNK1 in complex with inhibitor Classification TRANSFERASE/TRANSFERASE INHIBITOR Compound Mitogen-activated protein kinase 8 Source Homo sapiens (Human) (MK08_HUMAN) Sequence A:  DNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDA ILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNII GLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQMELDHE RMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLK ILDFGLSFMMTVTRYYRAPEVILGMGYKENVDLWSVGCIM GEMVCHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPT VRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQAR DLLSKMLVIDASKRISVDEALQHPYINVWYDPSEAEAPPP KIPDKQLDEREHTIEEWKELIYKEVMD Description Functional site 1) chain A residue 35 type sequence G description BINDING SITE FOR RESIDUE SO4 A 402 source : AC1 2) chain A residue 36 type sequence A description BINDING SITE FOR RESIDUE SO4 A 402 source : AC1 3) chain A residue 69 type sequence R description BINDING SITE FOR RESIDUE SO4 A 402 source : AC1 4) chain A residue 153 type sequence K description BINDING SITE FOR RESIDUE SO4 A 402 source : AC1 5) chain A residue 25 type sequence R description BINDING SITE FOR RESIDUE SO4 A 403 source : AC2 6) chain A residue 48 type sequence L description BINDING SITE FOR RESIDUE SO4 A 403 source : AC2 7) chain A residue 288 type sequence K description BINDING SITE FOR RESIDUE SO4 A 403 source : AC2 8) chain A residue 244 type sequence P description BINDING SITE FOR RESIDUE SO4 A 404 source : AC3 9) chain A residue 245 type sequence C description BINDING SITE FOR RESIDUE SO4 A 404 source : AC3 10) chain A residue 303 type sequence V description BINDING SITE FOR RESIDUE SO4 A 404 source : AC3 11) chain A residue 304 type sequence I description BINDING SITE FOR RESIDUE SO4 A 404 source : AC3 12) chain A residue 305 type sequence D description BINDING SITE FOR RESIDUE SO4 A 404 source : AC3 13) chain A residue 188 type sequence T description BINDING SITE FOR RESIDUE SO4 A 405 source : AC4 14) chain A residue 189 type sequence R description BINDING SITE FOR RESIDUE SO4 A 405 source : AC4 15) chain A residue 192 type sequence R description BINDING SITE FOR RESIDUE SO4 A 405 source : AC4 16) chain A residue 230 type sequence Y description BINDING SITE FOR RESIDUE SO4 A 405 source : AC4 17) chain A residue 32 type sequence I description BINDING SITE FOR RESIDUE CFK A 1 source : AC5 18) chain A residue 34 type sequence S description BINDING SITE FOR RESIDUE CFK A 1 source : AC5 19) chain A residue 40 type sequence V description BINDING SITE FOR RESIDUE CFK A 1 source : AC5 20) chain A residue 53 type sequence A description BINDING SITE FOR RESIDUE CFK A 1 source : AC5 21) chain A residue 109 type sequence E description BINDING SITE FOR RESIDUE CFK A 1 source : AC5 22) chain A residue 110 type sequence L description BINDING SITE FOR RESIDUE CFK A 1 source : AC5 23) chain A residue 111 type sequence M description BINDING SITE FOR RESIDUE CFK A 1 source : AC5 24) chain A residue 112 type sequence D description BINDING SITE FOR RESIDUE CFK A 1 source : AC5 25) chain A residue 113 type sequence A description BINDING SITE FOR RESIDUE CFK A 1 source : AC5 26) chain A residue 168 type sequence L description BINDING SITE FOR RESIDUE CFK A 1 source : AC5 27) chain A residue 151 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027 source Swiss-Prot : SWS_FT_FI1 28) chain A residue 116 type MOD_RES sequence C description S-nitrosocysteine => ECO:0000250|UniProtKB:P49185 source Swiss-Prot : SWS_FT_FI3 29) chain A residue 32 type BINDING sequence I description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 30) chain A residue 55 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 31) chain A residue 183 type MOD_RES sequence T description Phosphothreonine; by MAP2K7 => ECO:0000269|PubMed:11062067 source Swiss-Prot : SWS_FT_FI4 32) chain A residue 147-159 type prosite sequence IIHRDLKPSNIVV description PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IiHrDLKpsNIVV source prosite : PS00108 33) chain A residue 61-163 type prosite sequence FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEE FQDVYIVMELMDANLCQVIQMELDHERMSYLLYQMLCGIK HLHSAGIIHRDLKPSNIVVKSDC description MAPK MAP kinase signature. FqnqthakrayRElvlmkcvnhkniigllnvftpqksleefqdvyivmelmdanlcqviqmeldhermsyllyqmlcgikhlhsagiih..........RDlKpsnivvksdC source prosite : PS01351

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