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eF-site ID
|
3puf-ABCDEFGHIJKLMNOPQR |
|
PDB Code
|
3puf |
|
Chain
|
A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R |
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click to enlarge
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Title
|
Crystal structure of human RNase H2 complex |
|
Classification
|
HYDROLASE |
|
Compound
|
Ribonuclease H2 subunit A |
|
Source
|
null (RNH2C_HUMAN) |
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Sequence
|
A: |
MDLSELERDNTGRCRLSSPVPAVCRKEPCVLGVDEAGRGP
VLGPMVYAICYCPLPRLADLEALKVADSKTLLESERERLF
AKMEDTDFVGWALDVLSPNLISTSMLGRVKYNLNSLSHDT
ATGLIQYALDQGVNVTQVFVDTVGMPETYQARLQQSFPGI
EVTVKAKADALYPVVSAASICAKVARDQAVKKWQFVEKLQ
TDYGSGYPNDPKTKAWLKEHVEPVFGFPQFVRFSWRTAQT
ILEKEAEDVIWEDSSHRYFLERGLESATSL
|
| B: |
MRQHVFLVSEYLLMFVKLVNPCSGEGAIYLFNMCLQQLFE
VKVFKEKHHSWFINQSVQSGGLLHFATPVDPLFLLLHYLI
KADKEGKFQPLDQVVVDNVFPNCILLLKLPGLEKLLHHVT
EEKGNPKKYYKYSKEKTLKWLEKKVNQTVAALKTNNVNEE
DYIRYAHGLISDYIPKELSDDLSKY
|
| C: |
AIERHRVHLRSATLRDAVPATLHLLPCEVAVDGPAPVGRF
FTPAIRQGPEGLEVSFRGRCLRGEEVAVPPGLVGYVMVTE
EDRFIGATANFSRFTLWGLETIPGPDAKVRGALTWPSLAA
AIHAQVP
|
| D: |
DLSELERDNTGRCRLSSPVPAVCRKEPCVLGVDEAGRGPV
LGPMVYAICYCPLPRLADLEALKVADSKTLLESERERLFA
KMEDTDFVGWALDVLSPNLISTSMLGRVKYNLNSLSHDTA
TGLIQYALDQGVNVTQVFVDTVGMPETYQARLQQSFPGIE
VTVKAKADALYPVVSAASICAKVARDQAVKKWQFVEKLQD
LDTDYGSGYPNDPKTKAWLKEHVEPVFGFPQFVRFSWRTA
QTILEKEAEDVIWEDSASSHRYFLERGLESATSL
|
| E: |
MRQHVFLVSEYLKDMKNGLMFVKLVNPCSGEGAIYLFNMC
LQQLFEVKVFKEKHHSWFINQSVQSGGLLHFATPVDPLFL
LLHYLIKADKEGKFQPLDQVVVDNVFPNCILLLKLPGLEK
LLHHVTKYYKYSKEKTLKWLEKKVNQTVAALKTNNVKEED
YIRYAHGLISDYIPKELSDDL
|
| F: |
AIERHRVHLRSATLRDAVPATLHLLPCEVAVDGPAPVGRF
FTPAIRQGPEGLEVSFRGRCLRGEEVAVPPGLVGYVMVTE
EFDRFIGATANFSRFTLWGLETIPGPDAKVRGALTWPSLA
AAIHAQVP
|
| G: |
DNTGRCRLSSPVPAVCRKEPCVLGVDEAGRGPVLGPMVYA
ICYCPLPRLADLEALKVADSKTLLESERERLFAKMEDTDF
VGWALDVLSPNLISTSMLGRVKYNLNSLSHDTATGLIQYA
LDQGVNVTQVFVDTVGMPETYQARLQQSFPGIEVTVKAKA
DALYPVVSAASICAKVARDQAVKKWQFVEKLQDLDTDYGS
GYPNDPKTKAWLKEHVEPVFGFPQFVRFSWRTAQTILEKE
AEDVIWEDSASHRYFLERGLESATSL
|
| H: |
HMRQHVFLVSEYLKDASKKMKNGLMFVKLVNPCSGEGAIY
LFNMCLQQLFEVKVFKEKHHSWFINQSVQSGGLLHFATPV
DPLFLLLHYLIKADKEGKFQPLDQVVVDNVFPNCILLLKL
PGLEKLLHHVTEEKGNKKYYKYSKEKTLKWLEKKVNQTVA
ALKTNNVNVSSRVKEEDYIRYAHGLISDYIPKELSDDLSK
YL
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| I: |
AAIERHRVHLRSATLRAVPATLHLLPCEVAVDGPAPVGRF
FTPAIRQGPEGLEVSFRGRCLRGEEVAVPPGLVGYVMVTE
EKKVSEEEPLERDFDRFIGATANFSRFTLWGLETIPGPDA
KVRGALTWPSLAAAIHAQVP
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| J: |
LSELERDNTGRCRLSSPVPAVCRKEPCVLGVDEAGRGPVL
GPMVYAICYCPLPRLADLEALKVADSKTLLESERERLFAK
MEDFVGWALDVLSPNLISTSMLGRVKYNLNSLSHDTATGL
IQYALDQGVNVTQVFVDTVGMPETYQARLQQSFPGIEVTV
KAKADALYPVVSAASICAKVARDQAVKKWQFVEKLDLDTD
YGSGYPNDPKTKAWLKEHVEPVFGFPQFVRFSWRTAQTIL
EKEAEDVIWEDSASSHRYFLERGLESATSL
|
| K: |
HMRQHVFLVSEYLLMFVKLVNPCSGEGAIYLFNMCLQQLF
EVKVFKEKHHSWFINQSVQSGGLLHFATPVDPLFLLLHYL
IKADKEGKFQPLDQVVVDNVFPNCILLLKLPGLEKLLHHV
TEEKKKYYKYSKEKTLKWLEKKVNQTVAALKTNNVNDYIR
YAHGLISDYIPKELSDDLSKYL
|
| L: |
ERHRVHLRRDAVPATLHLLPCEVAVDGPAPVGRFFTPAIR
QGPEGLEVSFRGRCLRGEEVAVPPGLVGYVMVTEIGATAN
FSRFTLWGLETIPGPDAKVRGALTWPSLAAAIHAQV
|
| M: |
DLSELERDNTGRCRLSSPVPAVCRKEPCVLGVDEAGRGPV
LGPMVYAICYCPLPRLADLEALKVADSKTLLESERERLFA
KMEDTDFVGWALDVLSPNLISTSMLGRVKYNLNSLSHDTA
TGLIQYALDQGVNVTQVFVDTVGMPETYQARLQQSFPGIE
VTVKAKADALYPVVSAASICAKVARDQAVKKWQFVEKLQD
LDTDYGSGYPNDPKTKAWLKEHVEPVFGFPQFVRFSWRTA
QTILEKEAEDVIWEDSSHRYFLERGLESATSL
|
| N: |
MRQHVFLVSEYLKLMFVKLVNPCSGEGAIYLFNMCLQQLF
EVKVFKEKHHSWFINQSVQSGGLLHFATPVDPLFLLLHYL
IKADKEGKFQPLDQVVVDNVFPNCILLLKLPGLEKLLHHV
TEEKDNKKYYKYSKEKTLKWLEKKVNQTVAALKTNNVNVS
SEDYIRYAHGLISDYIPKELSDDLSK
|
| O: |
IERHRVHLVPATLHLLPCEVAVDGPAPVGRFFTPAIRQGP
EGLEVSFRGRCLRGEEVAVPPGLVGYVMVTRFIGATANFS
RFTLWGLETIPGPDAKVRGALTWPSLAAAIHAQVPE
|
| P: |
ELERDNTGRCRLSSPVPAVCRKEPCVLGVDEAGRGPVLGP
MVYAICYCPLPRLADLEALKVADSKTLLESERERLFAKME
DTDFVGWALDVLSPNLISTSMLGRVKYNLNSLSHDTATGL
IQYALDQGVNVTQVFVDTVGMPETYQARLQQSFPGIEVTV
KAKADALYPVVSAASICAKVARDQAVKKWQFVEGSGYPND
PKTKAWLKEHVEPVFGFPQFVRFSWRTAQTILEKEAEDVI
WEDSHRYFLERGLESATSL
|
| Q: |
MRQHVFLVSELMFVKLVNPCSGEGAIYLFNMCLQQLFEVK
VFKEKHHSWFINQSVQSGGLLHFATPVDPLFLLLHYLIKA
DKEKFQPLDQVVVDNVFPNCILLLKLPGLEKLLHHVTEEK
KYYKYSKEKTLKWLEKKVNQTVAALKTNNVNVIRYAHGLI
SDYIPKELSDDLSKYL
|
| R: |
ERHRVHLRVPATLHLLPCEVAVDGPAPVGRFFTPAIRQGP
EGLEVSFRGRCLRGEEVAVPPGLVGYVMVTDRFIGATANF
SRFTLWGLETIPGPDAKVRGALTWPSLAAAIHAQV
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Description
|
|
|
|
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1)
|
chain |
G |
| residue |
34 |
| type |
MOD_RES |
| sequence |
D
|
| description |
N-acetylmethionine => ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22223895, ECO:0007744|PubMed:22814378
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
2)
|
chain |
G |
| residue |
35 |
| type |
MOD_RES |
| sequence |
E
|
| description |
N-acetylmethionine => ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22223895, ECO:0007744|PubMed:22814378
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
3)
|
chain |
G |
| residue |
141 |
| type |
MOD_RES |
| sequence |
D
|
| description |
N-acetylmethionine => ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22223895, ECO:0007744|PubMed:22814378
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
4)
|
chain |
J |
| residue |
34 |
| type |
MOD_RES |
| sequence |
D
|
| description |
N-acetylmethionine => ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22223895, ECO:0007744|PubMed:22814378
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
5)
|
chain |
J |
| residue |
35 |
| type |
MOD_RES |
| sequence |
E
|
| description |
N-acetylmethionine => ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22223895, ECO:0007744|PubMed:22814378
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
6)
|
chain |
J |
| residue |
141 |
| type |
MOD_RES |
| sequence |
D
|
| description |
N-acetylmethionine => ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22223895, ECO:0007744|PubMed:22814378
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
7)
|
chain |
M |
| residue |
34 |
| type |
MOD_RES |
| sequence |
D
|
| description |
N-acetylmethionine => ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22223895, ECO:0007744|PubMed:22814378
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
8)
|
chain |
M |
| residue |
35 |
| type |
MOD_RES |
| sequence |
E
|
| description |
N-acetylmethionine => ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22223895, ECO:0007744|PubMed:22814378
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
9)
|
chain |
M |
| residue |
141 |
| type |
MOD_RES |
| sequence |
D
|
| description |
N-acetylmethionine => ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22223895, ECO:0007744|PubMed:22814378
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
10)
|
chain |
P |
| residue |
34 |
| type |
MOD_RES |
| sequence |
D
|
| description |
N-acetylmethionine => ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22223895, ECO:0007744|PubMed:22814378
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
11)
|
chain |
P |
| residue |
35 |
| type |
MOD_RES |
| sequence |
E
|
| description |
N-acetylmethionine => ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22223895, ECO:0007744|PubMed:22814378
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
12)
|
chain |
P |
| residue |
141 |
| type |
MOD_RES |
| sequence |
D
|
| description |
N-acetylmethionine => ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22223895, ECO:0007744|PubMed:22814378
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
13)
|
chain |
A |
| residue |
204 |
| type |
MOD_RES |
| sequence |
T
|
| description |
Phosphothreonine => ECO:0007744|PubMed:18669648
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
14)
|
chain |
A |
| residue |
216 |
| type |
MOD_RES |
| sequence |
T
|
| description |
Phosphothreonine => ECO:0007744|PubMed:18669648
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
15)
|
chain |
D |
| residue |
204 |
| type |
MOD_RES |
| sequence |
T
|
| description |
Phosphothreonine => ECO:0007744|PubMed:18669648
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
16)
|
chain |
D |
| residue |
216 |
| type |
MOD_RES |
| sequence |
T
|
| description |
Phosphothreonine => ECO:0007744|PubMed:18669648
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
17)
|
chain |
G |
| residue |
204 |
| type |
MOD_RES |
| sequence |
T
|
| description |
Phosphothreonine => ECO:0007744|PubMed:18669648
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
18)
|
chain |
G |
| residue |
216 |
| type |
MOD_RES |
| sequence |
T
|
| description |
Phosphothreonine => ECO:0007744|PubMed:18669648
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
19)
|
chain |
J |
| residue |
204 |
| type |
MOD_RES |
| sequence |
T
|
| description |
Phosphothreonine => ECO:0007744|PubMed:18669648
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
20)
|
chain |
J |
| residue |
216 |
| type |
MOD_RES |
| sequence |
T
|
| description |
Phosphothreonine => ECO:0007744|PubMed:18669648
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
21)
|
chain |
M |
| residue |
204 |
| type |
MOD_RES |
| sequence |
T
|
| description |
Phosphothreonine => ECO:0007744|PubMed:18669648
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
22)
|
chain |
M |
| residue |
216 |
| type |
MOD_RES |
| sequence |
T
|
| description |
Phosphothreonine => ECO:0007744|PubMed:18669648
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
23)
|
chain |
P |
| residue |
216 |
| type |
MOD_RES |
| sequence |
T
|
| description |
Phosphothreonine => ECO:0007744|PubMed:18669648
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
24)
|
chain |
A |
| residue |
257 |
| type |
MOD_RES |
| sequence |
S
|
| description |
Phosphoserine => ECO:0000250|UniProtKB:Q9CWY8
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|
|
25)
|
chain |
D |
| residue |
257 |
| type |
MOD_RES |
| sequence |
S
|
| description |
Phosphoserine => ECO:0000250|UniProtKB:Q9CWY8
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|
|
26)
|
chain |
G |
| residue |
257 |
| type |
MOD_RES |
| sequence |
S
|
| description |
Phosphoserine => ECO:0000250|UniProtKB:Q9CWY8
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|
|
27)
|
chain |
J |
| residue |
257 |
| type |
MOD_RES |
| sequence |
S
|
| description |
Phosphoserine => ECO:0000250|UniProtKB:Q9CWY8
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|
|
28)
|
chain |
M |
| residue |
257 |
| type |
MOD_RES |
| sequence |
S
|
| description |
Phosphoserine => ECO:0000250|UniProtKB:Q9CWY8
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|
|
29)
|
chain |
P |
| residue |
257 |
| type |
MOD_RES |
| sequence |
S
|
| description |
Phosphoserine => ECO:0000250|UniProtKB:Q9CWY8
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|