eF-site ID 3pta-A PDB Code 3pta Chain A click to enlarge Title Crystal structure of human DNMT1(646-1600) in complex with DNA Classification Transferase/DNA Compound DNA (cytosine-5)-methyltransferase 1 Source null (3PTA) Sequence A:  AFKRRRCGVCEVCQQPECGKCKACKDMVKFGGSGRSKQAC QERRCPNMAMKEADDDEEVDDNIPEMPSPKKMHQGKKKKQ NKNRISWVGEAVKTDGKKSYYKKVCIDAETLEVGDCVSVI PDDSSKPLYLARVTALWEDSSNGQMFHAHWFCAGTDTVLG ATSDPLELFLVDECEDMQLSYIHSKVKVIYKAPSENWAME GGMDPGKTYFYQLWYDQDYARFESPPKTQPTEDNKFKFCV SCARLAEMRQKEIPRVLEQLEDLDSRVLYYSATKNGILYR VGDGVYLPPEAFTFNIKLSSPKEPVDEDLYPEHYRKYSNL DAPEPYRIGRIKEIFCPKKSNGRPNETDIKIRVNKFYRPE NTHKSTPASYHADINLLYWSDEEAVVDFKAVQGRCTVEYG EDLPECVQVYSMGGPNRFYFLEAYNAKSKSFEDPPNHARS PGKLPKLRTLDVFSGCGGLSEGFHQAGISDTLWAIEMWDP AAQAFRLNNPGSTVFTEDCNILLKLVMAGETTNSRGQRLP QKGDVEMLCGGPPCQGFSGMNRFNSRTYSKFKNSLVVSFL SYCDYYRPRFFLLENVRNFVSFKRSMVLKLTLRCLVRMGY QCTFGVLQAGQYGVAQTRRRAIILAAAPGEKLPLFPEPLH VFAPRACQLSVVVDDKKFVSNITRLSSGPFRTITVRDTMS DLPEVRNGASALEISYNGEPQSWFQRQLRGAQYQPILRDH ICKDMSALVAARMRHIPLAPGSDWRDLPNIEVRLSDGTMA RKLRYTHHDRKNGRSSSGALRGVCSCVACDPAARQFNTLI PWCLPHTGNRHNHWAGLYGRLEWDGFFSTTVTNPEPMGKQ GRVLHPEQHRVVSVRECARSQGFPDTYRLFGNILDKHRQV GNAVPPPLAKAIGLEIKLCMLAKA Description Functional site 1) chain A residue 1145 type sequence F description BINDING SITE FOR RESIDUE SAH A 1601 source : AC1 2) chain A residue 1146 type sequence S description BINDING SITE FOR RESIDUE SAH A 1601 source : AC1 3) chain A residue 1147 type sequence G description BINDING SITE FOR RESIDUE SAH A 1601 source : AC1 4) chain A residue 1150 type sequence G description BINDING SITE FOR RESIDUE SAH A 1601 source : AC1 5) chain A residue 1151 type sequence L description BINDING SITE FOR RESIDUE SAH A 1601 source : AC1 6) chain A residue 1168 type sequence E description BINDING SITE FOR RESIDUE SAH A 1601 source : AC1 7) chain A residue 1169 type sequence M description BINDING SITE FOR RESIDUE SAH A 1601 source : AC1 8) chain A residue 1170 type sequence W description BINDING SITE FOR RESIDUE SAH A 1601 source : AC1 9) chain A residue 1189 type sequence E description BINDING SITE FOR RESIDUE SAH A 1601 source : AC1 10) chain A residue 1191 type sequence C description BINDING SITE FOR RESIDUE SAH A 1601 source : AC1 11) chain A residue 1225 type sequence P description BINDING SITE FOR RESIDUE SAH A 1601 source : AC1 12) chain A residue 1247 type sequence L description BINDING SITE FOR RESIDUE SAH A 1601 source : AC1 13) chain A residue 1266 type sequence E description BINDING SITE FOR RESIDUE SAH A 1601 source : AC1 14) chain A residue 1578 type sequence N description BINDING SITE FOR RESIDUE SAH A 1601 source : AC1 15) chain A residue 1579 type sequence A description BINDING SITE FOR RESIDUE SAH A 1601 source : AC1 16) chain A residue 1580 type sequence V description BINDING SITE FOR RESIDUE SAH A 1601 source : AC1 17) chain A residue 1476 type sequence C description BINDING SITE FOR RESIDUE ZN A 1 source : AC2 18) chain A residue 1478 type sequence C description BINDING SITE FOR RESIDUE ZN A 1 source : AC2 19) chain A residue 1485 type sequence C description BINDING SITE FOR RESIDUE ZN A 1 source : AC2 20) chain A residue 1502 type sequence H description BINDING SITE FOR RESIDUE ZN A 1 source : AC2 21) chain A residue 653 type sequence C description BINDING SITE FOR RESIDUE ZN A 2 source : AC3 22) chain A residue 656 type sequence C description BINDING SITE FOR RESIDUE ZN A 2 source : AC3 23) chain A residue 659 type sequence C description BINDING SITE FOR RESIDUE ZN A 2 source : AC3 24) chain A residue 691 type sequence C description BINDING SITE FOR RESIDUE ZN A 2 source : AC3 25) chain A residue 793 type sequence H description BINDING SITE FOR RESIDUE ZN A 3 source : AC4 26) chain A residue 820 type sequence C description BINDING SITE FOR RESIDUE ZN A 3 source : AC4 27) chain A residue 893 type sequence C description BINDING SITE FOR RESIDUE ZN A 3 source : AC4 28) chain A residue 896 type sequence C description BINDING SITE FOR RESIDUE ZN A 3 source : AC4 29) chain A residue 664 type sequence C description BINDING SITE FOR RESIDUE ZN A 5 source : AC5 30) chain A residue 667 type sequence C description BINDING SITE FOR RESIDUE ZN A 5 source : AC5 31) chain A residue 670 type sequence C description BINDING SITE FOR RESIDUE ZN A 5 source : AC5 32) chain A residue 686 type sequence C description BINDING SITE FOR RESIDUE ZN A 5 source : AC5 33) chain A residue 687 type sequence Q description BINDING SITE FOR RESIDUE ZN A 5 source : AC5 34) chain A residue 1218-1230 type prosite sequence EMLCGGPPCQGFS description C5_MTASE_1 C-5 cytosine-specific DNA methylases active site. EmLcgGpPCqGFS source prosite : PS00094 35) chain A residue 1574-1592 type prosite sequence RQVGNAVPPPLAKAIGLEI description C5_MTASE_2 C-5 cytosine-specific DNA methylases C-terminal signature. RqvGNAVpPpLakaIgleI source prosite : PS00095 36) chain A residue 653 type BINDING sequence C description BINDING => ECO:0000255|PROSITE-ProRule:PRU00509 source Swiss-Prot : SWS_FT_FI3 37) chain A residue 656 type BINDING sequence C description BINDING => ECO:0000255|PROSITE-ProRule:PRU00509 source Swiss-Prot : SWS_FT_FI3 38) chain A residue 659 type BINDING sequence C description BINDING => ECO:0000255|PROSITE-ProRule:PRU00509 source Swiss-Prot : SWS_FT_FI3 39) chain A residue 664 type BINDING sequence C description BINDING => ECO:0000255|PROSITE-ProRule:PRU00509 source Swiss-Prot : SWS_FT_FI3 40) chain A residue 667 type BINDING sequence C description BINDING => ECO:0000255|PROSITE-ProRule:PRU00509 source Swiss-Prot : SWS_FT_FI3 41) chain A residue 670 type BINDING sequence C description BINDING => ECO:0000255|PROSITE-ProRule:PRU00509 source Swiss-Prot : SWS_FT_FI3 42) chain A residue 686 type BINDING sequence C description BINDING => ECO:0000255|PROSITE-ProRule:PRU00509 source Swiss-Prot : SWS_FT_FI3 43) chain A residue 691 type BINDING sequence C description BINDING => ECO:0000255|PROSITE-ProRule:PRU00509 source Swiss-Prot : SWS_FT_FI3 44) chain A residue 1146 type BINDING sequence S description BINDING => ECO:0000250|UniProtKB:P13864 source Swiss-Prot : SWS_FT_FI4 45) chain A residue 1150 type BINDING sequence G description BINDING => ECO:0000250|UniProtKB:P13864 source Swiss-Prot : SWS_FT_FI4 46) chain A residue 1190 type BINDING sequence D description BINDING => ECO:0000250|UniProtKB:P13864 source Swiss-Prot : SWS_FT_FI4 47) chain A residue 1580 type BINDING sequence V description BINDING => ECO:0000250|UniProtKB:P13864 source Swiss-Prot : SWS_FT_FI4 48) chain A residue 1168 type BINDING sequence E description BINDING => ECO:0000269|PubMed:21163962, ECO:0007744|PDB:3PTA source Swiss-Prot : SWS_FT_FI5 49) chain A residue 1191 type BINDING sequence C description BINDING => ECO:0000269|PubMed:21163962, ECO:0007744|PDB:3PTA source Swiss-Prot : SWS_FT_FI5 50) chain A residue 1578 type BINDING sequence N description BINDING => ECO:0000269|PubMed:21163962, ECO:0007744|PDB:3PTA source Swiss-Prot : SWS_FT_FI5 51) chain A residue 714 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI6 52) chain A residue 732 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:18220336 source Swiss-Prot : SWS_FT_FI7 53) chain A residue 749 type MOD_RES sequence K description N6-acetyllysine => ECO:0000269|PubMed:21947282 source Swiss-Prot : SWS_FT_FI8 54) chain A residue 891 type MOD_RES sequence K description N6-acetyllysine => ECO:0000269|PubMed:21947282 source Swiss-Prot : SWS_FT_FI8 55) chain A residue 961 type MOD_RES sequence K description N6-acetyllysine => ECO:0000269|PubMed:21947282 source Swiss-Prot : SWS_FT_FI8 56) chain A residue 975 type MOD_RES sequence K description N6-acetyllysine => ECO:0000269|PubMed:21947282 source Swiss-Prot : SWS_FT_FI8 57) chain A residue 1054 type MOD_RES sequence K description N6-acetyllysine => ECO:0000269|PubMed:21947282 source Swiss-Prot : SWS_FT_FI8 58) chain A residue 1349 type MOD_RES sequence K description N6-acetyllysine => ECO:0000269|PubMed:21947282 source Swiss-Prot : SWS_FT_FI8 59) chain A residue 1415 type MOD_RES sequence K description N6-acetyllysine => ECO:0000269|PubMed:21947282 source Swiss-Prot : SWS_FT_FI8 60) chain A residue 878 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI9 61) chain A residue 1226 type ACT_SITE sequence C description source Swiss-Prot : SWS_FT_FI2

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