eF-site ID 3ppj-B PDB Code 3ppj Chain B click to enlarge Title Human B-Raf Kinase in Complex with a Furopyridine Inhibitor Classification TRANSFERASE/TRANSFERASE INHIBITOR Compound Serine/threonine-protein kinase B-raf Source Homo sapiens (Human) (BRAF_HUMAN) Sequence B:  DDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNV TAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAI VTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYL HAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVLSGSILW MAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNI NNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKK KRDERPLFPQILASIELLARSLPK Description Functional site 1) chain B residue 671 type sequence R description BINDING SITE FOR RESIDUE FOI A 727 source : AC1 2) chain B residue 471 type sequence V description BINDING SITE FOR RESIDUE FOI B 727 source : AC2 3) chain B residue 481 type sequence A description BINDING SITE FOR RESIDUE FOI B 727 source : AC2 4) chain B residue 483 type sequence K description BINDING SITE FOR RESIDUE FOI B 727 source : AC2 5) chain B residue 501 type sequence E description BINDING SITE FOR RESIDUE FOI B 727 source : AC2 6) chain B residue 527 type sequence I description BINDING SITE FOR RESIDUE FOI B 727 source : AC2 7) chain B residue 529 type sequence T description BINDING SITE FOR RESIDUE FOI B 727 source : AC2 8) chain B residue 532 type sequence C description BINDING SITE FOR RESIDUE FOI B 727 source : AC2 9) chain B residue 583 type sequence F description BINDING SITE FOR RESIDUE FOI B 727 source : AC2 10) chain B residue 594 type sequence D description BINDING SITE FOR RESIDUE FOI B 727 source : AC2 11) chain B residue 576 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027 source Swiss-Prot : SWS_FT_FI1 12) chain B residue 463 type BINDING sequence I description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 13) chain B residue 483 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 14) chain B residue 671 type MOD_RES sequence R description Omega-N-methylarginine; by PRMT5 => ECO:0000269|PubMed:21917714 source Swiss-Prot : SWS_FT_FI6 15) chain B residue 578 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:23907581 source Swiss-Prot : SWS_FT_FI7

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