eF-site ID 3pkc-A PDB Code 3pkc Chain A click to enlarge Title M. tuberculosis MetAP with bengamide analog Y08, in Mn form Classification Hydrolase/Hydrolase Inhibitor Compound Methionine aminopeptidase Source (AMPM_MYCTU) Sequence A:  RTALSPGVLSPTRPVPNWIARPEYVGKPAAQEGSEPWVQT PEVIEKMRVAGRIAAGALAEAGKAVAPGVTTDELDRIAHE YLVDNGAYPSTLGYKGFPKSCCTSLNEVICHGIPDSTVIT DGDIVNIDVTAYIGGVHGDTNATFPAGDVADEHRLLVDRT REATMRAINTVKPGRALSVIGRVIESYANRFGYNVVRDFT GHGIGTTFHNGLVVLHYDQPAVETIMQPGMTFTIEPMINL GALDYEIWDDGWTVVTKDRKWTAQFEHTLLVTDTGVEILT C Description Functional site 1) chain A residue 142 type sequence D description BINDING SITE FOR RESIDUE MN A 286 source : AC1 2) chain A residue 205 type sequence H description BINDING SITE FOR RESIDUE MN A 286 source : AC1 3) chain A residue 238 type sequence E description BINDING SITE FOR RESIDUE MN A 286 source : AC1 4) chain A residue 269 type sequence E description BINDING SITE FOR RESIDUE MN A 286 source : AC1 5) chain A residue 131 type sequence D description BINDING SITE FOR RESIDUE MN A 287 source : AC2 6) chain A residue 142 type sequence D description BINDING SITE FOR RESIDUE MN A 287 source : AC2 7) chain A residue 269 type sequence E description BINDING SITE FOR RESIDUE MN A 287 source : AC2 8) chain A residue 35 type sequence E description BINDING SITE FOR RESIDUE Y08 A 288 source : AC3 9) chain A residue 36 type sequence G description BINDING SITE FOR RESIDUE Y08 A 288 source : AC3 10) chain A residue 97 type sequence Y description BINDING SITE FOR RESIDUE Y08 A 288 source : AC3 11) chain A residue 114 type sequence H description BINDING SITE FOR RESIDUE Y08 A 288 source : AC3 12) chain A residue 131 type sequence D description BINDING SITE FOR RESIDUE Y08 A 288 source : AC3 13) chain A residue 142 type sequence D description BINDING SITE FOR RESIDUE Y08 A 288 source : AC3 14) chain A residue 203 type sequence T description BINDING SITE FOR RESIDUE Y08 A 288 source : AC3 15) chain A residue 205 type sequence H description BINDING SITE FOR RESIDUE Y08 A 288 source : AC3 16) chain A residue 212 type sequence H description BINDING SITE FOR RESIDUE Y08 A 288 source : AC3 17) chain A residue 214 type sequence G description BINDING SITE FOR RESIDUE Y08 A 288 source : AC3 18) chain A residue 238 type sequence E description BINDING SITE FOR RESIDUE Y08 A 288 source : AC3 19) chain A residue 269 type sequence E description BINDING SITE FOR RESIDUE Y08 A 288 source : AC3 20) chain A residue 131 type BINDING sequence D description BINDING => ECO:0000255|HAMAP-Rule:MF_01974, ECO:0000269|PubMed:15882055, ECO:0000269|PubMed:20038112, ECO:0000269|PubMed:21465667 source Swiss-Prot : SWS_FT_FI1 21) chain A residue 142 type BINDING sequence D description BINDING => ECO:0000255|HAMAP-Rule:MF_01974, ECO:0000269|PubMed:15882055, ECO:0000269|PubMed:20038112, ECO:0000269|PubMed:21465667 source Swiss-Prot : SWS_FT_FI1 22) chain A residue 205 type BINDING sequence H description BINDING => ECO:0000255|HAMAP-Rule:MF_01974, ECO:0000269|PubMed:15882055, ECO:0000269|PubMed:20038112, ECO:0000269|PubMed:21465667 source Swiss-Prot : SWS_FT_FI1 23) chain A residue 212 type BINDING sequence H description BINDING => ECO:0000255|HAMAP-Rule:MF_01974, ECO:0000269|PubMed:15882055, ECO:0000269|PubMed:20038112, ECO:0000269|PubMed:21465667 source Swiss-Prot : SWS_FT_FI1 24) chain A residue 238 type BINDING sequence E description BINDING => ECO:0000255|HAMAP-Rule:MF_01974, ECO:0000269|PubMed:15882055, ECO:0000269|PubMed:20038112, ECO:0000269|PubMed:21465667 source Swiss-Prot : SWS_FT_FI1 25) chain A residue 269 type BINDING sequence E description BINDING => ECO:0000255|HAMAP-Rule:MF_01974, ECO:0000269|PubMed:15882055, ECO:0000269|PubMed:20038112, ECO:0000269|PubMed:21465667 source Swiss-Prot : SWS_FT_FI1 26) chain A residue 114 type BINDING sequence H description BINDING => ECO:0000255|HAMAP-Rule:MF_01974, ECO:0000269|PubMed:15882055, ECO:0000269|PubMed:20038112, ECO:0000269|PubMed:21465667 source Swiss-Prot : SWS_FT_FI1 27) chain A residue 202-220 type prosite sequence FTGHGIGTTFHNGLVVLHY description MAP_1 Methionine aminopeptidase subfamily 1 signature. FtGHGIGttfHnglvVl.HY source prosite : PS00680

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